The effect of ultraviolet irradiation on the progression of Chinese hamster cells through the cell cycle. ANL-7535.
Explore the source record for details and available documents.
Biomedical subjects
Publications and source records attributed to W K Sinclair.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Hydroxyurea has a differential lethal effect on cultured Chinesehamster cells that are at different stages in their cell cycle. Cells synthesizing DNA at the time of exposure to the drug are lethally damaged. Cells in the phase of growth preceding DNA synthesis (G(1)) survive but are prevented from beginning DNA synthesis. Cells in the phase after DNA synthesis (G(2)) survive and appear to progress until just before the beginning of the next period of DNA synthesis. This differential lethal and inhibitory effect of hydroxyurea may be useful for synchronizing asynchronous cell populations and explaining effects of the drug in human therapy.
Explore the source record for details and available documents.