Search PubMed⌕ Search

Biomedical subjects

W K Silvers

Publications and source records attributed to W K Silvers.

At least 109 records · Page 6Linked to original sources
PubMed1975

Cellular basis of tolerance in neonatally induced mouse chimeras.

In mice, thymectomized as young adults, neonatally induced tolerance persists in the putative absence of cell chimerism. The finding provides evidence that a selective deficiency of specific clones of lymphocytes exists in transplantation tolerance when induced under the conditions of these experiments.

Animals↗
PubMed1975

Expression in organ culture of agouti locus genes of the mouse.

CLEFFMANN (1963) reported that pigment cells of the lethal yellow (A-y/a) genotype change to black immediately upon cultivation, and continue to produce black pigment unless sulfhydryl reagents are added to the culture medium. We have attempted to repeat this observation and have not been able to do so. We also have been unable to indue the synthesis of yellow pigment by adding glutathione to cultures of agouti (A/A) skin. We therefore suggest that hypotheses which attempt to explain the action of agouti locus genes on the basis of effects of sulfhydryl compounds be considered with caution.

Animals↗
PubMed1975

Obituary.

Explore the source record for details and available documents.

Histocompatibility↗
PubMed1975

Number of histocompatibility loci in Syrian hamsters.

Syrian hamsters descended from animals captured in the summer of 1971 have been utilized to obtain some estimate of the number of histocompatibility loci in this species. The survival of skin grafts on two F2 populations derived from these animals and two isogenic stocks indicates considerably more histocompatibility loci than previously reported.

Animals↗
PubMed1975

The influence of foster nursing on the survival and immunologic competence of mice and rats.

A series of experiments were undertaken in mice and rats to confirm the report that foster nursing rats of one strain, on mothers of a different strain, can influence their survival and immunologic competence as a consequence of their receiving a significant number of immunologically competent leukocytes via the milk. These experiments have included foster nursing mice and rats, either immediately after birth, or when 25 to 36 hr old, on H-2 incompatible and Ag-B compatible and incompatible mothers, respectively, and challenging them with ear skin grafts of the same genotype as their surrogate mother. They also have included fostering animals rendered tolerant of their surrogate mother's transplantation antigens. In no instance was any evidence obtained that foster nursing can prejudice the survival or influence the immunologic competence of mice or rats.

Animals↗
PubMed1973

Male specific antigen: homology in mice and rats.

Male lymphoid cells from some strains of rats can sensitize C57BL/6 female mice against C57BL/6 male skin grafts; this indicates that the male specific antigen of these two species is homologous.

Animals↗
PubMed1973

The genetic divergence of sublines as assessed by histocompatibility testing.

The degree of genetic divergence which has occurred between a number of inbred strains of mice and between two sublines of inbred rats was assessed by determining the fate of inter-subline skin grafts. Sublines which had been separated for 29 and 42 generations possessed no detectable incompatibility, while three combinations of sublines judged to have been maintained apart for from 123 to 129 generations showed slight degrees of histoincompatibility. One pair of sublines which had been separated for 119 generations demonstrated a marked degree of incompatibility, and an F(2) test suggested that mutations had occurred at four or five histocompatibility loci.

Animals↗