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Biomedical subjects

W K Mebust

Publications and source records attributed to W K Mebust.

At least 55 records · Page 3Linked to original sources
PubMed1981

The relationship of herpesvirus to carcinoma of the prostate.

A laboratory based epidemiologic study was done to determine the possible relationship of herpesvirus type 2 to carcinoma of the prostate. A total of 305 patients (224 with benign prostatic hypertrophy and 81 with prostatic carcinoma) who underwent transurethral resection of the prostate was studied. Viral cultures were obtained from urethral swabs and urine preoperatively. Prostatic tissue removed at operation was grown as tissue explants, using a monolayer cell culture technique, and examined by specific immunofluorescence and electron microscopy for evidence of herpesvirus type 2. The sera of the patients also were tested for specific antibody to herpesvirus type 2 by the indirect hemagglutination inhibition test. Although herpesvirus was not isolated 5 per cent of the patients had evidence of herpesvirus type 2 antigen in prostatic tissues by specific immunofluorescence. Electron microscopy failed to reveal the presence of viral particles. There was an increased prevalence of herpesvirus type 2 antibody in patients with carcinoma of the prostate compared to the controls with benign prostatic hypertrophy (p less than 0.05). Although marital status was similar the patients with prostatic cancer tended to marry at an earlier age, have more children, more sexual partners and more exposure to prostitutes than their counterparts with benign prostatic hypertrophy. The demonstration of specific herpesvirus type 2 antibody in patients with prostatic cancer supports an etiologic role for herpesvirus type 2 but further studies are needed to describe more definitively the relationship since the indexes of sexual activity are remarkably high in both groups.

Antibodies, Viral↗
PubMed1981

Primary neoplasms of the ureter.

The role of tobacco as a carcinogenic agent should be considered in ureteral carcinoma. In our study 77 per cent of the patients had a history of smoking, with an average of 50 packs a year consumption. Various studies have shown that the prognosis for ureteral carcinoma is related primarily to the grade and stage of the disease at the time of treatment. Therefore, it is imperative that the clinician maintain a high index of suspicion. This index of suspicion should be heightened in any patient with lower tract urothelial tumors. In addition to endoscopic followup excretory urography should be done on an annual basis, with retrograde studies when necessary. Ureteral brush biopsies or tissue obtained with the Dormia basket may be diagnostic. A Dormia stone basket was used in 3 patients in our study and sufficient tissue for diagnosis was obtained in each case. No complications were encountered. The results obtained in treating a primary leiomyosarcoma of the ureter are noteworthy in that complete remission of pulmonary metastases was obtained after the patient received a course of doxorubicin hydrochloride and dimethyl-triazeno imidazole carboxamide.

Adolescent↗
PubMed1981

Maturation of monocytes in patients with renal cell carcinoma.

Peripheral blood leukocytes were cultured from patients with renal cell carcinoma and compared with those from normal volunteers. The number of macrophage precursor cells recovered was 17.99 +/- 11.65 X 10(3) cells per ml of blood in patients with renal cell carcinoma, whereas the number recovered in normal individuals was 72.0 +/- 20.0 X 10(3) cells per ml of blood. The low macrophage yield in patients with renal cell carcinoma was not associated with serum factors, and there was no difference in the number of monocytes in the mononuclear cell preparations. Therefore, there seems to be an intrinsic defect in the macrophage maturation process in vitro in patients with renal cell carcinoma.

Adult↗
PubMed1980

Conversion of percutaneous ureteral stent to indwelling pigtail stent over guidewire.

A ureteral stent placed percutaneously through a nephrostomy can be readily exchanged endoscopically for a ureteral indwelling pigtail stent over a percutaneous guide wire. Percutaneous antegrade stent placement can sometimes be accomplished when retrograde placement cannot. We report 10 successful conversions to indwelling stent in 11 cases. In 1 case the percutaneous guide wire could not be retrieved endoscopically because of a bleeding tumor in the bladder. No serious difficulties or complications were encountered. The percutaneous approach offers an alternative method of providing internal urinary diversion if retrograde ureteral indwelling stent placement has failed.

Adult↗
PubMed1980

Subcutaneous implantation of percutaneous ureteral stents.

The authors describe their experience with subcutaneous implantation of percutaneous ureteral stents. Three of the five procedures were complicated by infection, urine leak and/or chronic drainage at some time during their course. One patient developed pressure changes of the skin overlying the implanted tube. The problems encountered in this initial experience are avoidable. Subcutaneous implantation of percutaneous ureteral stents can be useful in the management of appropriate patients.

Catheters, Indwelling↗
PubMed1979

Percutaneous ureteral stent placement for stricture management and internal urinary drainage.

Percutaneous ureteral stent placement was attempted in nine patients with 14 ureteral lesions. Eight strictures in six patients were successfully stented. Three were subsequently converted to indwelling ureteral stents. The technique is described. No significant complications occurred. The procedure should be attempted as part of percutaneous nephrostomy for benign ureteral strictures, ureteral fistulae, or when ever long term nonoperative diversion can be useful.

Aged↗
PubMed1978

Induction of canine autoantibody to prostatic neoantigen.

Electrodesiccation surgery of the prostate glands was completed on a total of seventy-one dogs. Disc electrophoresis, thin layer gel electrofocus and agar double diffusion studies demonstrated unique changes in the extracts of convalescent prostatic tissue that had persisted for at least 6 months when compared with pre-treatment extracts from seventeen of these dogs. The length of the period following electrodesiccation did not appear to affect the quality of the changes observed. Rabbit antisera to extracts of desiccated prostatic tissue contained antibody specific only for the autologous extract; however, cross-reactivity with altered antigen in homologous extracts could not be verified. In all dogs, generalized adverse effects were not detectable up to 16 months post-surgery.

Animals↗
PubMed1977

Urethral strictures following transurethral prostatectomy: review of 2,223 resections.

There were 2,223 consecutive transurethral prostatectomies reviewed in regard to the incidence and possible etiology of postoperative urethral strictures. Possible etiologies were evaluated and a mode of stricture formation was postulated. Factors considered to be important were 1) initial calibration of the urethra to determine anatomical adequacy prior to instrumentation, 2) gentle urethral dilatation, 3) the use of perineal urethrostomy in patients with strictures noted at the time of initial endoscopy and 4) the size of the urethral catheter used postoperatively.

Catheters, Indwelling↗
PubMed1977

Immune reactions following desiccation surgery of the canine prostate. An initial report.

Desiccation surgery of the canine prostate induces a chronic inflammatory cell infiltrate that persists at the site for more than 1 year. Specific autoantibody was demonstrated by direct immunofluorescence with prostatic tissue only. The mononuclear cell infiltrate occurring in large focal aggregates within 2 months after surgery was similar to the lesions seen in certain chronic inflammatory diseases. Precipitating antibody was not demonstrable by agar double diffusion techniques. The possible therapeutic effect of the induction of such a lesion in cancerous prostatic tissue is discussed.

Animals↗
PubMed1976

A second look at injection of vesical neck contractures with triamcinolone.

Adjuvant therapy for vesical neck contractures with triamcinolone injection has given good results with long-term followup but similar results have been obtained with transurethral resection alone in our current re-evaluation. Herein we review 220 consecutive vesical neck contractures treated by the aforementioned modalities.

Aged↗
PubMed1976

Fibrous histiocytoma of the bladder.

A case report of a fibrous histiocytoma of the bladder that presented as total, gross, painless hematuria with compression of the intramural ureter is described. Important pathologic aspects are presented and histiocytic tumors are discussed briefly. Any histiocytic tumor not related to a disease of lipid metabolism is rare and we have found no previous report of a fibrous histiocytoma of the bladder.

Histiocytoma, Benign Fibrous↗