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Biomedical subjects

W K Kinning

Publications and source records attributed to W K Kinning.

4 recordsLinked to original sources

Stercoral ulceration.

Stercoral ulceration is the loss of bowel integrity from the pressure effects of inspissated feces. The lesion usually occurs in constipated, bedridden patients and presents as an isolated lesion in the rectosigmoid area. Because of associated diseases in the population at risk, perforation and hemorrhage, the principal complications, result in a mortality exceeding 50 per cent. The diagnosis of perforated stercoral ulceration should be considered in any patient with a long-standing history of constipation who presents with acute abdominal pain and clinical findings consistent with perforation of a hollow viscus. Early celiotomy with vigorous debridement and irrigation of the peritoneal cavity and either exteriorization or resection with proximal colostomy is the treatment of choice. Since constipation and colonic dysfunction are more common in the older patient, as the mean age of the population increases, the surgeon may encounter this problem more often. Four patients with stercoral ulceration managed at the Medical College of Virginia Hospitals are added to the 53 patients previously reported in the literature.

Adult

Postoperative appendicitis.

Appendicitis developed in three patients during the postoperative period. At reoperation, perforation of the appendix occurred in all three instances and abscess was present in two. The postoperative status caused confusion in the diagnosis and led to inappropriate delay in operation. Failure to recognize appendicitis in the postoperative period suggests that a higher than normal incidence of rupture can be expected in this patient group.

Abdomen

Recovery in rats after spinal cord injury.

Previous studies from this laboratory have shown evidence of regeneration of long descending spinal motor tracts in rats after spinal cord transection and treatment to modify the animals' immune response. In this study, less extensive surgical lesions were combined with the most favorable drug treatment (75 mg per kilogram of cyclophosphamide in a single dose) in an effort to improve the prospects for regeneration. Less than complete spinal cord transections in the rat were frequently followed by clinical and electrophysiologic evidence of return of function. Such return of function appears to depend on a reorganization of the nervous system that results in the use of the few remaining fibers to transmit motor information rather than on regeneration. Immunosuppressive treatment had no effect on these results.

Animals

Dental abnormalities in rats after a single large dose of cyclophosphamide.

Delayed drug-related mortality in rats treated with a single high dose (75 mg/kg) of cyclophosphamide complicated experiments using this drug treatment. We observed that this delayed mortality was due to dental abnormalities including broken teeth, absent teeth, extra long teeth, and/or supernumerary teeth. These dental abnormalities developed about 140 days after treatment and, if left untreated, interfered with eating. Eventually, the untreated rats starved. Clipping their long teeth and feeding the rats powdered chow eliminated the deaths. Researchers should be aware that high doses of cyclophosphamide may result in dental abnormalities several months after the treatment.

Animals