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Biomedical subjects

W K Jacyk

Publications and source records attributed to W K Jacyk.

At least 19 recordsLinked to original sources
PubMed1996

Systemic lupus erythematosus in South African blacks: prospective study.

BACKGROUND: The aim of the study was to evaluate clinical and laboratory findings in black South African patients with systemic lupus erythematosus (SLE) and to compare these with findings in a group of white patients. MATERIALS AND METHODS: Forty black patients were studied. The group of exclusively white patients reported by Beutner et al. was used for comparison. RESULTS: A decreased frequency of malar rash, photosensitivity, and hematologic involvement was found in black patients. They had anti-Sm and anti-nRNP antibodies and low complement more often than white patients with SLE in Beutner et al. group. CONCLUSIONS: More differences have been noted in laboratory than in clinical parameters and findings reported in African-Americans with SLE have been confirmed in black Africans. Ethnic factors may play a role in the symptomatology of SLE.

Adolescent↗
PubMed1996

Pachydermatous eosinophilic dermatitis.

We report three South African black teenage girls with extensive pruritic papular lesions arising on a pachydermatous base, resembling severe atopic dermatitis or onchodermatitis. All three had peculiar hypertrophic genital lesions and peripheral blood eosinophilia. Histological studies showed an eosinophil-rich lymphohistiocytic infiltrate and variable fibrosis. Extensive fibrillar extracellular deposition of eosinophil granule major basic protein was demonstrated by an indirect immunofluorescence technique. A beneficial therapeutic effect was obtained using dapsone, prednisolone and cetirizine. The term pachydermatous eosinophilic dermatitis is proposed and its position among other conditions characterized by peripheral blood and skin tissue eosinophilia, is discussed.

Adolescent↗
PubMed1995

Annular granulomatous lesions in exogenous ochronosis are manifestation of sarcoidosis.

Annular lesions with histological changes that include a sarcoidal granulomatous reaction have been observed within hydroquinone-induced ochronotic changes in some patients. The clinical and histological similarity of these lesions to actinic granuloma has been reported previously. We describe six patients with annular granulomatous lesions located within the ochronotic areas. Three of them had evidence of systemic sarcoidosis. A comparison of the histological features of the annular lesions of this group with those of the three patients with only cutaneous sarcoidal changes showed only insignificant quantitative differences. We conclude that annular granulomatous lesions in patients with exogenous ochronosis is a form of sarcoidosis.

Adult↗
PubMed1994

Behçet's disease in South African blacks: report of five cases.

Behçet's disease is a multisystemic disorder characterized by oral and genital ulcers. Most commonly seen in the Middle East and Japan, it is rare in black Africans. Behçet's disease in five South African blacks is reported. The patients had a mucocutaneous type of the disease, similar to the form prevailing in Western Europe and the United States. One of the patients had neurologic manifestations, and none had uveitis. In four patients genital and cutaneous lesions responded to administration of dapsone, colchicine, or both.

Adult↗
PubMed1994

Bilateral large-cell calcifying Sertoli cell tumor of the testes with Peutz-Jeghers syndrome: a case report.

A 13-year-old boy with Peutz-Jeghers syndrome (PJs), gynecomastia, and bilateral multifocal testicular tumors is described. Histology of the testicular tissue disclosed large-cell calcifying Sertoli cell tumors. Females with PJs are known to be at increased risk of developing gonadal tumors. This case and a review of other reported cases suggest that males with PJs are also at risk for developing gonadal tumors.

Adolescent↗
PubMed1993

Seborrheic keratoses of black patients with epidermodysplasia verruciformis contain human papillomavirus DNA.

Epidermodysplasia verruciformis (EV) is a rare disease characterized by a generalized cutaneous infection with human papillomaviruses (HPVs) and a propensity for transformation of the lesions to squamous cell carcinomas on sun-exposed areas of the skin. Black-skinned patients with EV have a much lower incidence of skin cancer. Nine of 32 black African patients with EV presented deeply pigmented, flat or slightly raised lesions, located mostly in sun-exposed areas, that clinically had been diagnosed as seborrheic keratoses. Seborrheic keratoses are otherwise very rare in black Africans. Histology of these lesions disclosed seborrheic keratoses, lesions with seborrheic keratosis, and EV changes in the same biopsy specimens and seborrheic keratoses with features of bowenoid dysplasia. Reverse blot hybridization indicated the presence of DNA related to the HPV-5 group of papillomaviruses in seborrheic keratoses in three patients. Subsequent Southern blot analysis revealed a DNA that was related but not identical to any of the papillomaviruses in this HPV-5 group. The fourth lesion studied a few years earlier contained HPV-5c. The question arises whether a different type of HPV is responsible for development of these tumors in black patients with EV.

Adult↗
PubMed1993

Epidermodysplasia verruciformis and malignant thymoma.

We describe a patient with a long history of skin lesions clinically and histologically consistent with epidermodysplasia verruciformis (EV) who developed malignant thymoma. HPV-9DNA was found in the macular lesion and HPV-4DNA and HPV-9DNA in the coexistent common warts. Thrombocytopenia and hypogammaglobulinaemia preceded the diagnosis of thymoma. Our patient seems to represent an example of an EV-like syndrome in immunodeficiency.

Adult↗
PubMed1993

Epidermodysplasia verruciformis in Africans.

BACKGROUND: Epidermodysplasia verruciformis (EV) is a rare cutaneous disorder characterised by persistent, refractory infection with human papillomaviruses (HPV). Although EV does not seem to have racial or geographic preference, there is a scarcity of reports on its occurrence in Africans. METHODS: Twenty Africans with EV were studied, and the literature on this condition in Africans was reviewed. Virologic studies were performed on 10 patients. RESULTS: Three types of lesions were observed: flat warts, pityriasis versicolor-like macules, and seborrheic keratosis-like changes. Malignant transformation occurred in only one patient. HPV-3 was isolated only from flat warts, HPV-5 and HPV-17 were isolated only from PV-like lesions, whereas an HPV-5-related type was found in all three types of changes. HPV-5-related type revealed DNA that was related but not identical to any of the viruses in the HPV-5 group. This particular type was isolated from all five South African patients with EV in whom virologic studies were performed. CONCLUSIONS: The benign nature of EV in dark-skinned Africans has been confirmed. Four HPV types have been isolated, of which HPV-related type was found in all South African patients with EV and in all types of skin changes, regardless of their morphology. African patients with EV frequently present seborrheic keratosis-like changes.

Adolescent↗
PubMed1992

Primary neuritic leprosy in a black South African.

A case of primary neuritic leprosy in a black South African is described, in which the multiple peripheral nerves were affected. The clinical picture and electrophysiological studies are in keeping with a picture of mononeuritis multiplex. Selective involvement of the facial nerve branches with normal blink reflex latencies was observed. The biopsy of the sural nerve disclosed features most consistent with borderline leprosy.

Adult↗