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Biomedical subjects

W K Engel

Publications and source records attributed to W K Engel.

At least 307 records · Page 17Linked to original sources

Classification of neuromuscular disorders.

Anew type of classification of neuromuscular diseases is presented. It is based on etiology; when this is not possible, on pathogenesis; if neither is possible, on distinctive features, biochemical greater than morphologic greater than clinical-genetic ones. The initial categorization designates which cell type, lower motor neuron or myofiber, is considered responsible for the major abnormality. This classification is designed to promote understanding of the pathogenesis and etiology of neuromuscular diseases in general and be applicable to a particular patient when the diagnostic studies are completed. It is not arranged as an approach to the initial differential diagnosis of a given patient.

Amyloidosis↗

Histochemical abnormalities of skeletal muscle in patients with acute psychoses.

In 29 acutely psychotic patients (mostly schizophrenic), histochemical abnormalities of a myopathic type were demonstrated in skeletal muscle biopsies from 13 and were generally correlated with elevation of the "muscle" type isoenzymes of creatine phosphokinase in the patients' serum. The incidence was much higher than found in normal controls, hospitalized neurotic psychiatric patients, or parents of acutely psychotic patients. A diazo-coupling type of "alka-line phosphatase" reaction was particularly useful in identifying abnormal muscle fibers.

Alkaline Phosphatase↗