[Bronchial cytology after prolonged treatment with beclomethasone dipropionate].
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Biomedical subjects
Publications and source records attributed to W Jorde.
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Dust from mattresses of different composition and age was analysed for mites, xerophilic fungi and allergenic activity. The mites of the genus Demodex were the most abundant (58.2 per cent). Also pyroglyphid mites occurred commonly (36.6 per cent). Pyroglyphid mites were present in small numbers (mean: 1 specimen/0.2 g of dust) in 12 out of the 17 older polyester-foam mattresses. The 11 cotton-horsechair mattresses and the newly used polyester-foam mattresses (three tested) were without them. The dust from the cotton-horsehair mattresses had a significantly higher allergenic activity than from those of polyester-foam. Xerophilic fungi were isolated in three out of 31 mattresses. The species isolated belonged to the genus Aspergillus and Eurotium. E. repens occurred most frequently. Disinfection of mattresses was suggested to have a negative influence on the occurrence of mites and fungi.
In 20 volunteers histamine inhibition by fenoterol (Th 1165 a) was studied. The wheal and erythema reaction caused by intracutaneous application of 5 mug histamine can be inhibited by applying fenoterol in doses from 100--400 mug in form of a metered aerosol on the skin 5 min before the injection of histamine. In this study the dose-reaction effect yielded on ED50 of 140 mug fenoterol.
The protective and curative effect of Th 1165a (Fenoterol) and Salbutamol on the allergic rhinitis is reported. 70 patients with positive nasal provocation tests (speezing, rhinitis and eosinophilia of the secretions) were tested some days later with the same allergen after application of 100 mug TH 1165a. Protective effect could be shown in 64 patients who did not react with clinical symptoms. Another 85 patients were treated in the same way after a positive nasal provocation test and the clinical symptoms disappered within 5 minutes. In 10 patients nasal resistance was measured objectively by bodyplethysmography. Salbutamol showed the same protective and curative effect in 30 patients proved in the same way as described before. Application of the substances in the contralateral nostril had no systemic effect.
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During pollen development loading of pollen grains of rye with allergen(s) takes place in the anther. Young microspores after meiosis have no allergenic activity. Under greenhouse conditions rye pollen becomes allergenically active about 6 days before release of pollen grains from the anther.