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Biomedical subjects

W Jöchle

Publications and source records attributed to W Jöchle.

At least 19 recordsLinked to original sources
PubMed1991

[The effect of the sedative and analgesic detomidine for laryngoscopy of adult horses and foals].

Detomidine was used in this field trial effectively as a sedative and analgesic for laryngoscopic examinations in a total of 193 foals and 806 mature horses (Hanoverians). Detomidine was given either i.v. in foals 3 to 11 months old (20 micrograms/kg) and in mature horses (15 micrograms/kg), or i.m. in foals below 6 months of age (35 micrograms/kg). After i.v. administration, laryngoscopy was tolerated in more than 90% of all animals without additional use of a twitch, while in foals treated i.m. more than 70% required a twitch in order to enable this procedure. The effectiveness of detomidine was influenced by dose, route of administration, the time interval between treatment and examination and the degree of excitement before treatment, but not by sex. Profound bradycardia was evident in all treated animals, but arrhythmias were seen only in animals older than 4 months and were more pronounced in horses with a lower resting heart rate. These cardiovascular responses never endangered any of the treated animals. A transient dyspnea was seen in 13 foals (6.7%) and 10 horses (1.2%). Other side effects were rare. The foaling rate of 297 mares treated at any time during the first 8 months of pregnancy was 66.7%. A comparison with 5499 untreated, contemporary controls revealed a foaling rate of 61.0%. Hence treatments had no adverse effects on pregnancies.

Analgesics↗
PubMed1990

Plasma glucocorticoid concentrations in calves as an indicator of stress during parturition.

Plasma glucocorticoid concentrations and blood gas values were determined for 6 days in 47 newborn calves that had been subjected to various obstetrical procedures at term. Concentrations of glucocorticoids were uniformly high at birth (70 to 103 ng/ml). Increasing degrees of acidosis were accompanied by increasing glucocorticoid concentrations in plasma. Plasma glucocorticoid concentrations decreased sharply during the first 6 hours after delivery and reached a plateau at 48 hours after birth (14 to 21 ng/ml). The latter was taken as an indication that adaptation had been achieved. Calves subjected to severe pulling had higher glucocorticoid concentrations at birth (110.4 ng/ml) than calves requiring no assistance (88.3 ng/ml), calves requiring only slight assistance (83.8 ng/ml), or calves that had been delivered by cesarean section (82.9 ng/ml).

Acidosis↗
PubMed1989

Effects on pseudopregnancy, pregnancy and interoestrous intervals of pharmacological suppression of prolactin secretion in female dogs and cats.

Cabergoline, a new ergoline derivative, is a potent prolactin inhibitor. In this review, results are combined from previously published and unpublished blind laboratory and open clinical studies with cabergoline in pseudopregnant, pregnant and lactating bitches, in bitches with normal and prolonged cycles, and in pregnant queens. Dose-response studies in nursing bitches, using puppy weight as an endpoint, revealed that a dose of 5 micrograms/kg/day orally (for 5 days) was the optimal dose with a minimum of side effects. This dose effectively lowered blood prolactin concentrations in pregnant bitches and was partly luteolytic during the 1st half of gestation, and fully luteolytic during the 2nd half of gestation. Consequently, pregnancies were terminated in the 2nd half of pregnancy in the bitch, and in the queen. Treatment successes with pseudopregnancy and true and false lactation, including cases of eclampsia, were greater than 90%. The same level of success was seen in bitches with prolonged cycles (anoestrus). A 7-10-day treatment period resulted almost uniformly in oestrus, and restored fertility in greater than 80% of all bitches mated. Cycles were occasionally shortened in bitches treated for false lactation. Attempts to shorten cycles routinely in beagle bitches, in a commercial breeding operation, with a dose of 5 micrograms/kg/day for 14 days during months 4, 5 or 6 of the cycle were unsuccessful.

Abortion, Spontaneous↗
PubMed1987

Release of LH, FSH and GnRH into pituitary venous blood in mares treated with a PGF analogue, luprostiol, during the transition period.

Nine mares received cannulae to collect blood from the pituitary venous outflow in the intercavernous sinus (ICS) and the jugular vein; in 4 mares, only jugular cannulae were used. Those 4 mares and 3 of the mares with cannulae in both positions received 7.5 mg luprostiol i.m. and 1 mare with both cannulae was treated with 3.75 mg uprostiol i.v. Blood samples were kept before and after treatment at 2-, 5- or 10-min intervals and concentrations of LH, FSH and GnRH were determined by RIA. Treatments resulted in an immediate sharp rise of LH and FSH in ICS and jugular blood samples within 2-10 min, with ICS concentrations rising earlier, and with peak levels of LH 8 to 100 times higher, respectively. In ICS samples, GnRH was elevated consistently only after LH and FSH had reached peak levels. At both locations, LH and FSH concentrations remained elevated 60-120 min after treatment, but had returned to baseline by 240 min. In 5 untreated mares with cannulae at both locations, sampling at 5-min intervals for 12 or 24h revealed no pulses of LH or FSH in 3 mares, and only one pulse a day, preceded by several small rises of GnRH during the hour before the pulses, in 2 mares.

Animals↗
PubMed1987

[The sexual cycle in the bitch: recent insights and impact on therapy and reproduction control].

Present knowledge about the estrous cycle of the bitch has been reviewed from a morphological, endocrinological and clinical point of view. This cycle is truly biphasic, characterized by its slow motion. It includes pregnancy or pseudopregnancy, and lactation. Corpus luteum function and regression as well as endometrial recovery, following endometrial desquamation at about day 100 of the cycle, are finalized at about days 140 to 150. Soon thereafter, subclinical preparations for the next proestrus can be recognized. Prolactin seems to play an important role as a luteotrophic agent, beginning at about day 30 to 35 of the cycle. Inhibition of prolactin secretion can be used to induce abortion, or to inhibit lactation and to shorten the cycle, or to treat clinical anestrus. Late metestrus and subclinical proestrus, i.e. days 120 to 170 of the cycle, is the most suitable period of the cycle to initiate suppression of the cycle, i.e. prevention of the next estrus, by using progestins with the least tendency for side effects.

Animals↗
PubMed1981

Effect of Solcoseryl on the clinical course of experimental Escherichia coli-endotoxin mastitis.

Experimental Escherichia coli-endotoxin mastitis was induced in a single quarter in twenty-eight cows. The inflamed quarters of six of the cows were treated with 50 mg Solcoseryl infusion in an oil base starting 4-6 h after endotoxin infusion, and four additional infusions were given at 12-h intervals. The inflamed quarters of eight of the cows were similarly treated with 200 mg Solcoseryl whereas the remaining fourteen cows served as control. Solcoseryl treatment did not alter the systemic or local course of acute mastitis. Local reaction, as assessed by the California Mastitis Test (CMT), however, subsided considerably sooner in quarters treated with Solcoseryl, and the effect of Solcoseryl in hastening udder tissue repair processes appeared to be dose dependent. The 200 mg dose of Solcoseryl resulted in pre-endotoxin CMT scores as early as 6 days after endotoxin infusion.

Actihaemyl↗
PubMed1977

Effect of prostaglandins F2alpha and E2 on milk ejection, blood pressure and blood flow through the mammary artery in the cow.

The influence of prostaglandins (PG) F2alpha and E2 on milk ejection, mammary artery blood flow and arterial blood pressure was studied in lactating cows. Injections of both PG in the jugular vein or the carotid artery induced milk ejection after a relatively long latency period. The minimal effective dose amounted to 1 to 5 microng and to 100 to 300 microng for PGF2alpha and PGE2 respectively. In several cases with PGF2alpha and once with PGE2 milk ejection was accompanied with a simultaneous increase in blood flow through the mammary artery whereas arterial blood pressure remained unchanged. Both routes of administration showed the same response. It was suggested that the effect of the PG on the bovine myoepithelium is indirect, possibly secondary to a release of oxytocin from the neurohypophysis.

Animals↗