Search PubMed⌕ Search

Biomedical subjects

W J Williams

Publications and source records attributed to W J Williams.

At least 55 records · Page 3Linked to original sources
PubMed1989

Laser microprobe mass spectrometry (LAMMS) analysis of beryllium, sarcoidosis and other granulomatous diseases.

Beryllium was detected in the granulomas of all thirty-three cases of CBD examined and was absent in thirty cases of sarcoidosis. It was also found in association with coal dust in one of twelve normal lungs. Beryllium could also be detected in Schaumann bodies and hyalinized scars. Beryllium, though sometimes present in Kveim negative biopsies of CBD patients, was not found in any originating Kveim antigen. Rare earths (La, Ce, Pr and Nd) were unexpectedly found in two of the thirty sarcoid patients but not in any other samples. We have identified the crystalline component of Schaumann bodies as calcite and shown that they, as well as calispherules of microlithiasis, contain calcium phosphate. Al and Ti may be found in normal lungs but when associated with hypersensitivity granulomatous disease, their oxides were also present.

Berylliosis↗
PubMed1987

David Geraint James.

Explore the source record for details and available documents.

History, 20th Century↗
PubMed1987

Necrotising sarcoidal granulomatosis: a problem of identity. A study of seven cases.

We report on a study of 6 cases of Necrotising Sarcoidal Granulomatosis (NSG) and details of another problem case illustrating the difficulties of classification. We have compared the clinical and pathological features with those of sarcoidosis, Wegener's Granulomatosis (WG), Churg Strauss Granulomatosis (CSG), Pulmonary Hyalinizing Granuloma (PHG) and various metal lung diseases. We distinguish NSG from sarcoidosis, in particular by the prominence of vasculitis, necrosis and the rarity of extrapulmonary manifestations, but accept that problem cases can occur. We see no difficulty in separating NSG from CSG, PHG and metal lung granulomatous diseases, but on occasion WG may cause considerable difficulty. For the present NSG is best regarded as a distinct entity.

Adult↗
PubMed1986

New aid for diagnosing chronic beryllium disease (CBD): laser ion mass analysis (LIMA).

The value of laser ion mass analysis (LIMA) for the detection of beryllium disease in routine histological sections was investigated. Our results were based on the examination of 14 cases of confirmed and five cases of suspected chronic beryllium disease. With the exception of two cases of coal workers' lungs, all the control material, normal, tuberculous, and sarcoid lungs examined were free of beryllium. The technique may also be useful in other diseases of possible occupational origin.

Berylliosis↗
PubMed1985

Analysis of publication output of internal medicine faculty members.

The number of publications per year produced by a department of internal medicine faculty is analyzed. The output of the younger faculty members (40 years or less) averaged 1.4 publications a year, and the annual output of the older faculty (over 40 years) averaged 2.3 publications (p less than 0.05). The site of their primary clinical responsibilities did not significantly affect their publication productivity. In all subspecialty sections, the output of older faculty members correlated well with that of younger faculty members (p less than 0.005). The productivity of section chiefs correlated well with the productivity of younger faculty members in their respective sections (p less than 0.001). Younger faculty members who later entered private practice had a lower (p less than 0.02) publication output than those who left for another academic position. The output of faculty members is related to the age of the faculty members, overall sectional productivity, and productivity of the section chief.

Adult↗
PubMed1985

A case of gastric sarcoidosis.

A case of gastric involvement in a long standing patient with fibrotic sarcoidosis is reported. The diagnosis was made by the finding of Schaumann bodies in the gastric mucosa. At autopsy, the lungs were honeycombed with numerous Schaumann bodies, one of which shows ossification.

Adult↗
PubMed1983

A continuous information theoretic approach to the analysis of cutaneous receptor neurons.

Information theoretic and statistical techniques for determining the number of discernible levels in cutaneous receptor neurons are reviewed. Reasons for the large variance in these results are discussed. A new continuous information theoretic analysis technique is presented that overcomes many of the problems in the other methods of analysis discussed. Comparison of this new method of analysis with a statistical technique developed by Schreiner et al. (1978) clearly shows some of the misconceptions that are associated with statistical analysis techniques, and why these problems cannot arise in the new information theoretic technique discussed here.

Mathematics↗
PubMed1983

Cell saver.

Explore the source record for details and available documents.

Blood Cells↗