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Biomedical subjects

W J Shih

Publications and source records attributed to W J Shih.

At least 253 records · Page 14Linked to original sources
PubMed1976

A scintiphotographic study of pulmonary edema and hemorrhage induced by cerebral compression and norepinephrine.

Pulmonary edema and hemorrhage (PEH) was induced in rats by cerebral compression and intraveneous norepinephrine. We used scintiphotographic method to demonstrate the blood volume change in the lung subsequent to the hemodynamic events that cause PEH. A specific isotope, Indium-113m, was chosen for this purpose. The isotope forms large molecular, complex with plasma transferrin (molecular weight of roughly 90,000). It is evenly distributed inside the intravascular space. Normally, the lung showed little radioactivity. After cerebral compression or intravenous norepinephrine, a marked increase in radioactivity of the lung was evident. This indicates an accumulation of blood volume in that area. All the animals developed severe PEH which was proved postmortemly. Findings of the present as well as the previous studies agree with each other and indicate that either cerebral compression or norephinephrine elicits generalized systemic vasoconstriction, causing a shift of large amount of blood into the lung. The hemodynamic changes finally result in pulmonary hypertension and subsequent PEH. The scintiphostographic method may be employed as diagnostic tool when a hypervolemic lung change is suspected. Further quantitative analysis is to be accomplished for a prospective clinical application.

Animals↗
PubMed1975

Indium-113m perfusion study and the nonfunctioning thyroid nodule.

Indium-113m eluate has been used to study the perfusion of 12 patients with solitary thyroid nodules that appeared "cold" in the 131I and 99mTc image studies. Seven patients with colloid nodules showed no perfusion and the remaining five (three adenomas and two carcinomas) showed good perfusion with indium. Histologic confirmation was obtained in all cases. Indium-113m perfusion study may be useful in differentiating colloid nodules from either adenomas or carcinomas.

Adenoma↗
PubMedDate not supplied

Unilateral absence of lung perfusion on pulmonary scintigraphy secondary to lung cancer with extensive pleural metastases from lung cancer.

A man with a 20-year history of smoking who underwent Tc-99m MAA Pulmonary perfusion imaging, which showed virtually absent perfusion of the right lung and fairly normal perfusion of the left lung. Eighteen days after the study, the patient died; at autopsy poorly differentiated carcinoma of the right lung was confirmed, which included extensive thickened pleura and plaques deposits and compression of the right lung; 200 ml of bloody pleural effusion was also found on the right side. The unilateral absence of lung perfusion on Tc-99m MAA pulmonary scintigraphy might reflect the autopsy findings of the right lung and pleura.

Aged↗