Search PubMedSearch

Biomedical subjects

W J Marshall

Publications and source records attributed to W J Marshall.

At least 19 recordsLinked to original sources

Neuromuscular blockade in aeromedical airway management.

STUDY OBJECTIVE: Induction of paralysis before intubation is controversial in the aeromedical setting. We reviewed our experience using neuromuscular blockade with nurse/paramedic aeromedical teams to determine effectiveness and outcome. MATERIALS AND METHODS: In 670 flights during a 16-month period, 119 patients required endotracheal intubation aided by muscle relaxant administration. Age ranged from two months to 83 years, with a mean of 33 years. All patients were hyperventilated with 100% oxygen before intubation. Sedation was given if presenting systolic blood pressure was greater than 100 mm Hg. A short-acting depolarizing agent was then given in a 1-mg/kg dose. Once the airway was secure, a longer-acting, nondepolarizing agent and/or sedation was given. RESULTS: Of the 119 patients, 115 (96.6%) were orally intubated. Four (3.4%) required surgical airway intervention because of injuries and conditions prohibiting oral intubation. Of 115 oral intubations, 99 (86%) were achieved on the first attempt. Eight patients (7%) were intubated on a second attempt, and another eight were intubated on a third attempt. There was no change in operator. Sixty-eight percent of patients requiring airway management were multiple trauma victims with associated head injuries. There were no laryngeal injuries, detected cardiac rhythm changes, bleeding episodes, or neurologic complications despite incomplete cervical-spine evaluation. CONCLUSION: Neuromuscular blockade can be used safely and effectively in the field by experienced nurse/paramedic teams. Although problematic intubation was not eliminated, the difficulties encountered were manageable and the overall risk/benefit ratio was acceptable.

Adolescent

Plasma uric acid in patients receiving anticonvulsant monotherapy.

In newly diagnosed adult patients with epilepsy followed prospectively on monotherapy, carbamazepine and phenytoin were associated with a fall in plasma uric acid, but sodium valproate and phenobarbitone were associated with a rise in plasma uric acid. The mechanisms and significance of these findings are discussed.

Adolescent

In the end....

Explore the source record for details and available documents.

Altruism

Laser reflections from relatively flat specular surfaces.

A major element in laser range control procedures has been the control of stray reflections from glass reflectors which may be near the laser target. These hazardous reflections have been thought to extend as far as the direct beam for near grazing angles of incidence. Modern military laser rangefinders and designators can be hazardous to the unaided eye to distances of 10 km or even greater. For this reason, many square kilometers of laser range area have been necessary to conduct laser tests when flat specular reflectors may be present on targets. Fortunately, sophisticated pointing systems have been developed with these laser systems to ensure that the direct beam is confined to the immediate target area. In most cases, flat specular reflectors also have been eliminated from the immediate target area. In some instances, however, specular reflectors still exist near or on laser targets. For these special cases, a more definitive mathematical treatment of hazardous laser reflections is desired. The divergence of a laser beam which has been reflected from a flat specular surface is dependent on the size of the reflector, the divergence of the laser creating the reflection, and the curvature of the reflecting surface. It can be shown mathematically that the curvature of even an optical flat, a reference surface used to compare the flatness of other surfaces, will produce a significant additional beam spread, thereby reducing the hazards of reflected beams. The natural curvature of plate glass or window glass is much greater, reducing the hazards even further. The extent of the hazards for reflections of various types of lasers and reflecting surfaces is discussed.

Eye Injuries

Synchronized independent lung ventilation in the management of pediatric unilateral pulmonary contusion: case report.

Utilizing a double-lumen endobronchial tube, synchronized independent lung ventilation (SILV) was successfully employed to manage severe unilateral pulmonary contusion in a 6-year old trauma patient. This appears to represent the youngest reported patient in whom this technique has been utilized. Early institution of this treatment modality may substantially increase survival.

Accidents, Traffic

"Genericgate".

Explore the source record for details and available documents.

Crime

Frequency of pancreatitis in fulminant hepatic failure using isoenzyme markers.

Evidence of acute pancreatitis was sought in 35 patients with fulminant hepatic failure. Total amylase was raised in 22 patients and isoenzyme separation showed a distinct P3 isoenzyme (indicative of pancreatitis) in 14. In four patients with marked hyperamylasaemia (greater than 1000 U/l) the predominant isoenzyme was the salivary fraction. Pancreatic lipase was abnormally raised (greater than 200 U/l) in 34 patients but exceeded 1000 U/l in 12 of the 14 with a distinct P3 isoenzyme. Thus on the basis of a distinct P3 isoenzyme of amylase and an increased pancreatic lipase activity evidence of pancreatitis was found in 34% of patients in this series.

Acute Disease

Total parenteral nutrition and the clinical chemistry laboratory.

Parenteral nutrition is a well-established technique for feeding patients with intestinal failure and other conditions which render enteral feeding impossible. Biochemical tests are required in the initial assessment of these patients, for monitoring their response to treatment and for the detection and management of complications. The use of these tests is discussed critically and guidelines are provided for the frequency with which they should be performed. Chemical pathologists and clinical biochemists have an important role in the provision of parenteral nutrition as members of multi-disciplinary nutrition teams.

Cations

Current clinical laboratory practice: investigation of plasma lipids--which tests and when?

Clinical interest in the lipoproteins stems mainly from the association between serum cholesterol concentrations and coronary heart disease. Investigations of lipoproteins should be performed in patients with premature coronary heart disease, with a strong family history of coronary heart disease, or with certain cutaneous stigmata of hyperlipoproteinaemia and when fasting serum samples are seen to be lipaemic. Family studies should be performed in appropriate cases to identify relatives at increased risk of developing coronary heart disease. Patients with conditions known to cause secondary hyperlipoproteinaemia should be investigated if they fall into one of these categories but only after treatment of the underlying condition. Non-specialist laboratories should be able to measure total cholesterol and triglyceride concentrations and high density lipoprotein cholesterol concentrations. Lipoprotein electrophoresis has a limited role in such laboratories and is not necessary as a routine procedure. Specialist laboratories should in addition be able to measure individual lipoproteins and identify apolipoprotein E phenotypes.

Age Factors