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Biomedical subjects

W J Frable

Publications and source records attributed to W J Frable.

168 records · Page 10Linked to original sources
PubMedDate not supplied

Pulmonary cytopathology of an invasive thymoma.

The cytopathology of an invasive thymoma that penetrated the bronchus is presented. As is typical of these neoplasms histologically, both epithelial cells (thymocytes) and lymphocytes were seen cytologically. However, the benign appearance of the thymocytes precluded a neoplastic diagnosis initially. Only with the knowledge that an anterior mediastinal mass is present roentgenographically can this diagnosis be safely made cytologically.

Bronchial Neoplasms↗
PubMedDate not supplied

Development of a hospital information system for cytopathology.

The development of a system of ordering cytology tests and reporting cytodiagnoses as part of a hospital information system (HIS) is reported. Cytology tests are ordered by lightpen selections that carry the user along an ordering pathway that includes selection of specimen type, collection procedure information and a patient history matrix. On the patient history matrix the user is asked pertinent questions to which he or she may respond by making appropriate lightpen selections or type-ins. Test results ar communicated to HIS by the cytotechnologist through the accumulation of a series of lightpen selections with some type-in modifiers; this builds into a message containing a complete cytologic diagnosis.

Computers↗
PubMedDate not supplied

Subclassification of benign breast disease by fine needle aspiration cytology. Comparison of cytologic and histologic findings in 265 palpable breast masses.

The cytologic and histologic features of 265 benign breast masses were analyzed in order to examine the ability of fine needle aspiration cytology to accurately subclassify benign breast lesions. Two hundred two of the masses were pure histologic examples of benign breast lesions (72 nonproliferative fibrocystic change, 27 proliferative fibrocystic change, 65 fibroadenoma, 12 abscess, 8 fat necrosis, 7 papilloma, 7 duct ectasia, 2 tubular adenoma, 1 sclerosing adenosis, 1 microglandular adenosis), and 63 masses were mixed lesions. Part I of the study consisted of retrospective comparison of the original cytologic diagnoses with the histologic diagnoses. A nonspecific descriptive diagnosis had been rendered in 135 of 265 (51%) cases, and these descriptive diagnoses corresponded to fibrocystic change in the majority of cases (70%). A specific benign cytologic diagnosis had been made in 130 of 265 (49%) cases, and overall the specific diagnosis was correct in 80% of cases. Part II of the study consisted of the semiquantitative scoring of the cytologic findings of the 202 pure examples of benign breast masses and statistical analysis of differences in the expression of cytologic features between the different types of lesions. Overall cellularity, amount of bipolar stripped nuclei, amount and architectural arrangement of epithelium, epithelial atypia/pleomorphism/nuclear overlapping and amount of apocrine metaplasia, foam cells and stroma were the cytologic parameters that were statistically significant (P < .05) in distinguishing between the cases of fibroadenoma, abscess, papilloma, fat necrosis, duct ectasia and fibrocystic change as a group. No cytologic parameter reached statistical significance in distinguishing between proliferative and nonproliferative fibrocystic change. We conclude that the majority of benign breast lesions yield characteristic cytologic findings that allow their subclassification when sufficiently sampled by fine needle aspiration. The distinction between proliferative and nonproliferative fibrocystic change is less reliable, and cytologic differences observed within this spectrum did not reach statistical significance.

Biopsy, Needle↗
PubMedDate not supplied

Malignant melanoma of soft tissue. A report of three cases with diagnosis by fine needle aspiration cytology.

A correlated cytologic and histologic study of three cases of malignant melanoma of soft tissue (MMST) is presented. The patients' ages ranged from 21 to 36 years. Two were females and one, male. In two cases fine needle aspiration cytology was done to document local recurrence or metastatic disease and in one to establish a primary diagnosis. The cytologic findings were similar in all cases. The smears were composed of noncohesive tumor cells with monotonous, uniform nuclei, prominent nucleoli and plentiful, light blue cytoplasm. Immunohistochemical studies performed in all cases demonstrated staining positive for S-100 protein. Electron microscopy from two cases showed premelanosomes and melanosomes. These results demonstrate that a precise diagnosis of MMST can be rendered on material obtained by aspiration cytology.

Adult↗