Search PubMed⌕ Search

Biomedical subjects

W J Dougherty

Publications and source records attributed to W J Dougherty.

At least 37 records · Page 2Linked to original sources
PubMed1977

Second order auditory pathways in the chimpanzee.

Substantial portions of the dorsal, and almost the entire posteroventral and anteroventral (Av) cochlear nuclei were aspirated unilaterally in a chimpanzee. Axonal degeneration was studied by the Fink-Heimer method. The greatest amount of degeneration was followed medially from the region of Av into the lateral part of the trapezoid body. Degeneration also coursed around the superior surface of the restiform body and was traced into the dorsal and intermediate acoustic striae. Within the superior olivary complex, degeneration was distributed to: the ipsilateral lateral superior olive; laterally and medially oriented dendrites of the ipsilateral and contralateral medial superior olivary nuclei respectively (some perisomatic degeneration also was present bilaterally); the contralateral medial trapezoid nucleus; retro-olivary and preolivary cell groups bilaterally. Abundant degeneration passed into the contralateral lateral lemniscus and was distributed largely to its ventral nucleus. The contralateral central nucleus of the inferior colliculus was a major site of termination of ascending second order auditory fibers. The caudal tip of the ipsilateral ventral nucleus of the lateral lemniscus received abundant degeneration, but this diminished rostrally. The ipsilateral inferior colliculus contained a moderate amount of degeneration. A fair number of degenerated second order auditory fibers ascended in the contralateral brachium of the inferior colliculus and were distributed both to the principle and magnocellular divisions of the medial geniculate body. This pathway appears to represent a phylogenetic advance in the brain of the great ape.

Animals↗
PubMed1976

Microblebs of intestinal epithelial cell microvilli of Citellus tridecemlineatus.

The presence of microblebs arising from the lateral surfaces and tips of microvilli of intestinal epithelial cells of thirteen-lined ground squirrels. Citellus tridecemlineatus, is reported. Microblebs measure approximately 50 nm in diameter and are bounded by a unit membrane which is continuous with the unit plasma membrane of the microvilli. It is suggested that such microblebbing reflects the rapid turnover of microvillar contents, membrane and surface coat.

Animals↗
PubMed1975

The non-teratogenicity of 2,4,5-trichlorophenoxyacetic acid in the rhesus monkey (Macaca mulatta).

The herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) containing 0.05 ppm of tetrachlorodibenzo-p-dioxin, was administered to pregnant rhesus monkeys daily from Day 22 through Day 38 of gestation. At the dose levels administered, 0.05 mg/kg, 1 mg/kg, and 10 mg/kg, no evidence of toxicity was seen in the mother and no evidence of teratogenicity was seen in any of the offspring. Observations of the infants for 1 year following birth indicated that there was no toxicity due to the 2,4,5-T.

2,4,5-Trichlorophenoxyacetic Acid↗
PubMed1975

Radioimmunoassay of rhesus monkey chorionic gonadotropin.

A radioimmunoassay for rhesus monkey chorionic gonadotropin (mCG) employing an antiovine LH antiserum, 125I or 131I-ovine LH tracer, and mCG for standards was developed. Radioimmunoassay of serum levels of mCG during pregnancy indicated that mCG began increasing as early as day 12 after mating, reached a peak by day 25, and declined to nondetectable levels around day 35. The assay procedure was adapted for use as a rapid method for pregnancy diagnosis; the results were available as early as 12 hours after collection of serum samples. The method is capable of detecting a few pregnancies by day 12 and all pregnancies by day 17. Routine use of this method provided accurate pregnancy diagnosis four days earlier than was possible with the mouse uterine weight bioassay method previously used in this laboratory.

Animals↗