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Biomedical subjects

W J Bailey

Publications and source records attributed to W J Bailey.

42 records · Page 3Linked to original sources
PubMed1978

Structural factors influencing the biodegradation of imides.

Comparative studies on the biodegradability of amides and imides are presented. Low-molecular-weight imides of varying chain lengths (4, 6, 7, 8, 18, and 20 carbons) were biodegrable. N-alkyl substitution of amides and imides resulted in non-biodegrable derivatives when the amide portion was greater than two carbons in length. N-alkyl-substituted derivatives of acetamide or diacetamide, however, were biodegrable. Several soil isolates, including Aspergillus niger and species of Flavobacterium and Alcaligenes, were capable of growth with imides as sole N or C sources.

Alcaligenes↗
PubMed1973

12,13-Epoxy-delta 9-trichothecenes as the probable mycotoxins responsible for stachybotryotoxicosis.

Stachybotrys atra cultures grown on oats produced five compounds toxic to brine shrimp; three are the sesquiterpenoid mycotoxins known as 12,13-epoxy-Delta(9)-trichothecenes. One trichothecene is roridin E, a known metabolite of Myrothecium verrucaria. The other two were hydrolyzed to verrucarol, the product of roridin and verrucarin hydrolysis. Spectroscopic data indicate that the two remaining compounds are also 12,13-epoxy-Delta(9)-trichothecenes. These metabolites are probably among those responsible for stachybotryotoxicosis.

Animals↗
PubMedDate not supplied

Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: a resource for investigations into drug disposition.

Carrier-mediated transporters play a critical role in xenobiotic disposition and transporter research is complicated by species differences and their selective tissue expression. The purpose of this study was to generate a comprehensive data set of xenobiotic transporter gene expression profiles in humans and the pre-clinical species mouse, rat, beagle dog and cynomolgus monkey. mRNA expression profiles of 50 genes from the ABC, SLC and SLCO transporter superfamilies were examined in 40 human tissues by microarray analyses. Transporter genes that were identified as enriched in the liver or kidney, or that were selected for their known roles in xenobiotic disposition, were then compared in 22 tissues across the five species. Finally, as clinical variability in drug response and adverse reactions may be the result of variability in transporter gene expression, variability in the expression of selected transporter genes in 75 human liver donors were examined and compared with the highly variable drug metabolizing enzyme CYP3A4.

Animals↗
PubMedDate not supplied

Tobacco use by Indiana children and adolescents.

Data from a five-year, longitudinal survey of cigarette smoking and smokeless tobacco use by Indiana children and adolescents are presented. A four-page, self-contained questionnaire was used to collect anonymous information from more than 240,000 students in grades six through 12. Indiana students reported prevalence levels 20% to 50% higher than levels reported in comparable national surveys. Perceived risk of physical or psychological harm was the single best statistical predictor of whether or not a student would choose to use tobacco. Tobacco use was statistically linked to increased use of illicit drugs. Physicians can play a powerful role in influencing a patient's perception of the risks associated with cigarette smoking.

Adolescent↗