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Biomedical subjects

W I Worret

Publications and source records attributed to W I Worret.

At least 19 recordsLinked to original sources
PubMed1995

Mechanical properties of keloids in vivo during treatment with intralesional triamcinolone acetonide.

The mechanical properties of 17 keloids in 9 patients before and during treatment with intralesional triamcinolone acetonide were studied using a recently developed noninvasive suction device for measuring skin elasticity in vivo. Each keloid was treated with intralesional injections of 10 mg/ml triamcinolone acetonide without local anaesthetic at intervals of 3 weeks. A total of four measurements per keloid were performed, before treatment and 3 weeks after the first, second and third treatments. The parameters used were: immediate distension (Ue), delayed distension (Uv), immediate retraction (Ur) and final distension (Uf). Relative parameters independent of skin thickness were calculated: Uv/Ue, the ratio between the viscous and the elastic deformation of the skin, and Ur/Uf, representing the ability of the skin to return to its initial position after deformation (biological elasticity). After three injections of triamcinolone acetonide a marked decrease in Uv/Ue and a less-pronounced increase in Ur/Uf compared with baseline values was observed. These findings indicate that the main effect of intralesional steroids on the connective tissue of keloids is a decrease in viscosity due to a loss of ground substance. This method provides a noninvasive quantitative assessment of the mechanical properties of scars and is well suited to comparative studies on the efficacy of various scar therapies.

Adolescent↗
PubMed1995

Spindle-cell lipoma of the skin.

Spindle-cell lipoma of the skin is a distinct lesion that can occur in the dermis or subcutaneous tissue. The most important aspect of histologic differential diagnosis of this benign tumor is the exclusion of liposarcoma. We report two cases of spindle-cell lipoma, in which the clinical features of these lesions did not deviate appreciably from those of the usual lipomas. However, their microscopic appearances differed in terms of the distinctive spectrum of histological growth patterns. The clinical, immunohistochemical, and light and electron microscopic features of both cases were studied and compared with those of conventional lipoma and liposarcoma. Immunohistochemically both tumors showed no expression of insulin-like growth-factor receptors I and II. Coexpression of these receptors is usually observed in liposarcomas.

Aged↗
PubMed1994

Specific skin lesions in a patient with Niemann-Pick disease.

We report a patient with Niemann-Pick disease who developed papular lesions on the face. These showed ultrastructural findings typical of this disorder. Specific skin lesions such as these are an extremely rare manifestation of Niemann-Pick disease.

Adult↗
PubMed1992

Prevalence of dysplastic nevi in healthy young men.

Young white men (1176 men, mean age 20 years, age range from 18 to 26 years) were examined for dysplastic nevi. In 78 patients (6.63%), 107 clinically dysplastic nevi were observed, demonstrating all three NIH criteria (diameter greater than 5mm, irregularities of border, irregularities of color) suggestive for clinically dysplastic nevi. Of these, 71 nevi in 52 patients were excised and examined histologically, 46 nevi in 26 patients were not excised due to lack of patients' consent. Fifty-two of 78 (66.6%) patients with clinically dysplastic nevi agreed to excision. In these, seven nevi (13.5% of patients or 9.86% of all nevi excised) were confirmed by histology. According to these data, three additional patients with dysplastic nevi would have been expected among the 26 patients who refused surgery. Referring to the entire study group, the prevalence of dysplastic nevi in young white men is expected to be 0.85%.

Adolescent↗
PubMed1992

[Osteoma cutis. Pathogenesis and therapeutic possibilities].

No efficacious therapy for the treatment of increasing and spreading cutaneous ossification is yet established. We report a 52 year old white female with multiple miliary osteomas of the skin involving face, chest and back. The patient has a history of acne vulgaris. A therapeutic trial with a diphosphonate (etidronate disodium) was started in order to stop marked progression and appearance of new lesions. In accordance with the two previously described cases of the literature we failed to achieve any improvement. Clinical features, etiology, classification and therapy of osteoma cutis are discussed.

Breast Neoplasms↗
PubMed1992

[Stewart-Bluefarb syndrome].

We describe a 17-year-old Turkish girl with painful ulcerative pseudo-Kaposi lesions on the left foot and partial giant growth of the same leg. Stewart-Bluefarb syndrome is discussed with reference to this case.

Adolescent↗
PubMed1990

[Halo eczema and nevus cell nevi (Meyerson nevi)].

In the same way as a halo of depigmentation surrounds a sutton naevus, a halo of eczema can appear around a naevocellular naevus. This phenomenon was first described in 1971 by Meyerson, but publications on the topic are relatively sparse. We report a patient who consulted us because of such lesions. A review of literature is appended.

Adult↗
PubMed1989

[Exacerbation of rosacea in HIV infection].

A 38-year-old male homosexual patient, who had suffered from hepatopathy for many years and from rosacea since 15 years, showed pronounced exacerbation of the rosacea following HIV infection.

AIDS Serodiagnosis↗
PubMed1989

[Association of idiopathic acropustuloses to HLA antigens and their relation to psoriasis].

Immunogenetical findings can contribute to the understanding of diseases of unknown etiology. It has, however, become difficult to define the borderlines between related diseases, since a vast amount of individual facts have been reported. For this reason, immunogenetical findings should only be seen as a part of general pathology. Our study, which makes use of HLA markers, is an attempt to provide a better definition of idiopathic acropustulosis, and to differentiate it more clearly from psoriasis.

Acrodermatitis↗
PubMed1988

Abnormal cutaneous nerves in incontinentia pigmenti.

Cutaneous nerves showed multiple ultrastructural abnormalities in a patient with incontinentia pigmenti. Fetal nerve bundles were seen both in the dermis and entering the epidermis. A cell with some Schwann cell features was identified above the basal layer amid keratinocytes. Dermal melanophages were in close apposition to Schwann cells. All of these features suggest that neural structures may be abnormal in incontinentia pigmenti and play a role in transfer of melanin from epidermis to dermis.

Biopsy↗
PubMed1988

[Modern methods of acne therapy].

Today the treatment of acne vulgaris offers a broad spectrum of topic and systemic therapeutics. With these a optimal therapy in different acne-phases is practicable, and the possibility of scar formation is inhibited. The particular groups of substances are discussed regarding indication, action and contraindication.

Acne Vulgaris↗
PubMed1988

[Autosomal dominant genetic dermatoses and their association with internal cancers].

In this short review we attempt to high-light a number of syndromes in which the observant physician can occasionally diagnose a cancer-associated syndrome prior to development of internal malignancy and aid the patient and his physician in appropriate management, be it closer monitoring or therapeutic interventions.

Chromosome Aberrations↗