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Biomedical subjects

W I Onuigbo

Publications and source records attributed to W I Onuigbo.

At least 19 recordsLinked to original sources
PubMed2001

Ophthalmic presentation of epidermoid cysts in an African community.

This retrospective study reviews the clinical and histopathological features of ocular epidermoid cyst. The 30-year laboratory records of all the patients of the Igbo ethnic group, whose surgical specimens were received at a central pathology laboratory service in south-eastern Nigeria, West Africa, were reviewed. The cases with the histopathologic diagnosis of epidermoid cyst involving ocular tissues were reviewed. The data analyzed included age at diagnosis, sex, location and size of cyst, clinical description of lesion and operative diagnosis. There were eighteen patients. Ten (55.6%) of these were males and 8 (44.4%) were females. Nearly three-quarters were below the age of 20 years. The cyst was present from birth in 4 (22.2%) patients and was acquired in the rest. It occurred on the external angle of the orbit in 7 patients; on the bulbar conjunctiva in 4 patients; in the lower fornix, upper lid and medial canthus in two patients each; and on the lower lid in one patient. There was no correct diagnosis of epidermoid cyst clinically, the most common misdiagnoses being dermoid cyst (55.6%) and conjunctival cyst (16.7%). Accordingly, epidermoid cyst should be included in the differential diagnosis of cystic lesions showing ophthalmic presentation.

Acute Disease↗
PubMed2001

Comparative study of adult polycystic kidney disease.

An Ethiopian series dealt with 4 cases of adult polycystic kidney disease and mentioned the paucity of it in analyses of hospital admission in African literature. The present series on the lgbos of Nigeria, West Africa, compares well with the Ethiopian experience and constitutes one more group to be placed on the world map of this intriguing disease.

Adult↗
PubMed2000

Ten anomalous patterns of lung cancer spread with a single explanatory hypothesis.

Lung cancer is so strategically sited in relation to the pulmonary veins, left heart, and aorta that its disseminating cells have the greatest possible opportunities for being distributed everywhere. Consequently, because scientists need to be ever watchful for the unexpected, this review points out ten topographical patterns of its metastases which are at variance with expectations from blood-borne dispersal. Since a comparative study of disseminated lung cancer cells returning to the lung through the thoracic duct and of those cells carried to the contralateral lung blood vessels revealed that necrotic cancer cells are commoner in blood than in lymph, it is hypothesized that the anomalous patterns occur because of the degree of lethal exposure experienced by these cells during blood-borne transportation. Therefore, in all probability, if the secrets of Nature hitherto hidden in the blood stream are well decoded, a new era will dawn in oncology.

Humans↗
PubMed1991

Potential pathogenicity of Cladosporium tennuisimum, Phaeoisaria clematidis and Ramichloridium subulatum in a mouse model.

The potential pathogenicity of one isolate each of Cladosporium tennuisimum, Phaeoisaria clematidis and Ramichloridium subulatum for mice was investigated by intravenous, intraperitoneal and subcutaneous routes of inoculation with saline and mucin suspensions of the organisms. No mice died during the experimental period. Dark nodular lesions were formed in the liver, spleen, kidneys, intestine, stomach, omentum and diaphragm after inoculation through the intravenous and intraperitoneal routes. Gross lesions were produced in the lungs of one mouse inoculated intravenously with R. subulatum. Localised nodular lesions were formed in the subcutis following the subcutaneous route. Tissue response was characterised by granulomatous inflammatory reaction. Fungal elements were confined within the granulomata. Though the fungi showed limited pathogenic potential, they may represent a hazard under conditions of compromised host immunity.

Animals↗
PubMed1987

Metastasis to the umbilicus: possible racial difference.

Umbilical metastasis is rare. A review of the available American literature suggests that it is relatively more common in blacks than in whites. Prospective research is indicated, as this would add to knowledge of cutaneous-reaction patterns peculiar to racial groups.

Abdominal Neoplasms↗
PubMed1986

The Paget cell. Mistaken for a parasite in the 19th century.

Sir James Paget in 1874 described clinically a disease of the skin that bears his name. Its dermatopathologic aspect was partly elucidated during the years that followed. This led to a theory that the Paget cell was a carcinogenic parasitic body. George Thomas Beatson, on recognizing the erroneous nature of the parasitic theory of cancer, was led logically to propose and successfully to carry out bilateral ovariectomy for advanced cancer of the breast by 1896.

Breast Neoplasms↗
PubMed1985

Appendiceal schistosomiasis. Method of classifying oviposition and inflammation.

Twenty surgical specimens of appendiceal schistosomiasis were reviewed retrospectively. They constituted 1 percent of 1984 appendices seen among approximately 15,000 surgical specimens examined at free central laboratories serving the Igbos of Nigeria, West Africa. Oviposition by Schistosoma haematobium was classified according to its association with suppurative appendicitis and normal appendices. Seven of ten infested appendices obtained at curative operations showed suppurative appendicitis, whereas eight of nine infested appendices removed at incidental appendectomies were negative. One interval appendectomy was also negative. It is postulated that utilization of this novel classification on a worldwide basis will help to end the controversy concerning the etiologic role of schistosome ova in acute appendicitis.

Adolescent↗
PubMed1985

Expert evidence. Historical perspectives.

Nearly 150 years ago, a seaman received a blow on the right side in the liver region, dying a month later. As a result of fresh autopsy findings, the accused was arrested and imprisoned. However, the defense counsel obtained an exhumation order. This led to the discovery of coexisting lethal disease and culminated in full discharge by a grand jury. The various aspects of the case are examined and shown to anticipate modern principles of expert evidence.

Alcoholism↗
PubMed1985

Carcinoma of skin of penis.

Like the Jews, the Ibos or Igbos of Nigeria ritually circumcise males on the eighth day of birth. A retrospective review of approximately 15,000 surgical specimens collected from this ethnic group over a period of 13 years revealed 32 cases of carcinoma of the prostate but only 4 cases of penile carcinoma. One tumour arose on the glans penis. This localisation pattern suggests that, in circumcised males, smegma-induced squamous carcinoma of the glans can be abolished but not the ordinary squamous carcinoma that can develop by chance on the rest of the penis as well as on the glans. International urology would benefit from careful documentation of squamous carcinoma affecting various parts of the neonatally circumcised penile skin.

Aged↗