Dissolution of model gallstones in bile acid solutions I: implications for T-tube infusion treatment of retained common duct stones with the cholate system.
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Biomedical subjects
Publications and source records attributed to W I Higuchi.
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In vitro studies on the dissolution rate of cholesterol monohydrate crystals in micellar bile acid solutions showed that the addition of lecithin decreases the dissolution rate even though lecithin increases the equilibrium solubility of cholesterol in these solutions. The reduction in rates caused by lecithin was attributed to a large crystal-solution interfacial barrier. An effective permeability coefficient for the interfacial barrier was calculated to be around 1.5 x 10(-5) centimeter per second for the transport of cholesterol molecules.
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