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Biomedical subjects

W Hunstein

Publications and source records attributed to W Hunstein.

At least 109 records · Page 6Linked to original sources
PubMed1979

Leukocyte alkaline phosphatase in malignancies.

The leukocyte alklaine phosphatase (LAP) levels were determined in 183 patients with malignant diseases and 71 normal controls. The median LAP scores were 64 units (range 0 to 290) for the patients and 55 (range 2 to 158) for the controls, respectively, and no significant difference could be established. When analyzed according to primary malignancy, only in patients with Hodgkin's disease (n = 14) was the median value higher than normal (p less than 0.001). In patients with distant metastases (n = 48), higher LAP levels were demonstrated (M = 76, range 21 to 290) as compared to patients with no evidence of metastases (M = 53, range 0 to 229), (p less than 0.01). Thus, LAP activity has very limited value in the diagnosis of malignancies. Its elevation in the presence of malignant disease might, however, indicate metastases.

Adult↗
PubMed1978

[Intestinal yersiniosis: 25 cases of infections with Yersinia pseudotuberculosis and Yersinia enterocolitica (author's transl)].

Yersinia infections in 16 adults and 9 children are reported. 15 cases were caused by Yersinia pseudotuberculosis, 8 of them were proved by serological findings. In 4 cases the infection by Yersinia pseudotuberculosis was likely, in 3 other cases possible only. Real infections caused by serotype IV are demonstrated too. Furthermore there were 10 cases caused by Yersinia enterocolitica, 3 of them were proved by bacterial, the other ones by serological findings. Both germs caused identical symptoms: fever (80%), abdominal pains (56%), diarrhoea (52%), erythema nodosum (44%), arthritis (40%), vomiting (16%), weight loss (16%), lymphoma (12%) and others. In children 50% of erythema nodosum was produced by intestinal yersiniosis. The beginning with gastroenteritis and fever mostly was followed by a second phase with returning fever, abdominal pains, erythema nodosum and/or arthritis. Antibiotic therapy had a definite effect only in the first phase of gastroenteritis and in the two possibly relapsing cases. In two of 5 patients with long standing arthritis the HL-AB 27 was present.

Adolescent↗
PubMed1977

Acquired pyruvate kinase deficiency with hemolysis in preleukemia.

Acquired erythrocyte pyruvate kinase deficiency may appear as a symptom secondary to various hematologic disorders, e.g. acute leukemia, sideroblastic anemia, polycythemia vera. The case of a 68-year-old patient with PK deficiency (1.75 U/g Hb) and severe hemolytic anemia is presented, who 1 year later showed acute myeloid leukemia. It is considered that a dialysable inhibiting factor may play a pathogenetic role in this enzyme change since enzyme activity was raised by dialysis. A survey of the literature is presented.

Anemia, Hemolytic↗
PubMed1977

[Iron absorption after oral application of a combination of Fe2+-succinate and multivitamins (author's transl)].

The rate of iron absorption of Fe2+-succinate orally applied with multivitamins, was measured by means of whole-body counter in 45 subjects. The dosage was 330 mg ferrous succinate (115 mg Fe2+). Absorption was generally 4.5% (5.2 mg) in normal subjects, 8.6% (9.9 mg) in subjects with latent iron deficiency, and 29.6% (34 mg) in subjects with manifest iron deficiency. In women taking oral contraceptives and not suffering from iron deficiency, no significant increase in the iron absorption rate was measured.

Administration, Oral↗
PubMed1975

[Proceedings: Hematopoiesis in chronic pyelonephritis. Quantitative-morphological study].

Bone marrow biopsies from the iliac crest in 56 patients with chronic pyelonephritis were evaluated quantitively and correlated with renal function and peripheral blood values (n = 100). In proportion to increasing serum creatinine, mild marrow hypoplasia develops which mainly, and to a statistically significant extent, affects the percentage and amount of erythropoietic cells and megakaryocytes. The simultaneous reduction of erythrocytes and reticulocytes in peripheral blood is more pronounced and only slightly correlated to the marrow cells. There is no correlation between the number of peripheral granulocytes or the decrease in lymphocytes concomitant with uremia, and their respective precursors in the marrow.

Bone Marrow Examination↗
PubMed1975

[A simplified macrophage migration inhibition test to measure T-cell derived immunity in man].

A macrophage migration inhibition test using heterologous cells (DMMTH) is performed in an agarose-droplet technique. A suspension consisting of peritoneal exsudate cells from Guinea pig and human lymphocytes, mixed with 0,2 percent agarose is dispensed in droplets with a dispenser into culture chambers used for the leukocyte migration inhibition test. Macrophages migrate out of the gelified droplets. Migration areas can be measured by planimetry. Migration areas are exact to 8.6 percent. A significant migration inhibition, caused by migration inhibitory factors is observed after the reaction of the specific antigen with sensitized lymphocytes in the agarose droplet. The sensitivity of the test has been demonstrated in Mantoux positive persons.

Cell Migration Inhibition↗