Biomedical subjects
Publications and source records attributed to W Hung.
Pituitary enlargement can occur as a result of primary hypothyroidism. We present a newborn with pituitary enlargement and congenital hypothyroidism secondary to a lingual thyroid gland. Thyroid hormone therapy caused a regression of pituitary enlargement.
Pseudohypoparathyroidism type Ia (PHP type Ia) is associated with several endocrinopathies. We describe two siblings with PHP type Ia, hypothyroidism and growth hormone deficiency (GHD). To our knowledge, these patients are the first to have PHP type Ia and GHD. The defect which is most likely responsible for the three endocrinopathies is a deficiency of the stimulatory guanine nucleotide-binding regulatory protein, Gs.
The relationship between control and serum lipids was examined in 147 children with juvenile-onset diabetes (JOD). Control was assessed by fasting blood glucose, 24-h urine glucose, and fast hemoglobin. There was a significant positive correlation (P less than 0.001) between each of the measures of control. Serum cholesterol (P less than 0.001), triglycerides (P less than 0.001), and low-density lipoprotein plus very low-density lipoprotein cholesterol (P less than 0.001) were strongly positively correlated with control for the whole group of patients. High-density lipoprotein was not significantly correlated with control when the data for the whole group were analyzed but was significantly positively correlated with fasting blood glucose when patients were analyzed individually.
OBJECTIVE: To describe a pediatric patient with an anterior neck mass and discuss the evaluation and treatment. METHODS: We present a case report and a discussion of the differential diagnosis of anterior cervical masses. The workup and therapy for an anterior neck mass, which was a thyroglossal duct cyst, are reviewed. RESULTS: A thyroglossal duct cyst in pediatric patients is an uncommon finding. For establishing a correct diagnosis, surgical confirmation is necessary. Identification is important because of the high incidence of misdiagnosis, recurrent infections, inadequate treatment, and possible neoplastic change. CONCLUSION: A thyroglossal duct cyst should be included in the differential diagnosis of an anterior neck mass. Recommended treatment consists of surgical removal of the cyst, the entire thyroglossal duct tract, and the central portion of the hyoid bone.
A male neonate with marked breast hypertrophy associated with transient hyperprolactinemia is reported. The breast hypertrophy resolved when the serum prolactin levels decreased to normal. Ultrasonographic finding of the breast hypertrophy are presented. It is not known if the hyperprolactinemia was etiologically related to the breast hypertrophy.