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Biomedical subjects

W Huber

Publications and source records attributed to W Huber.

At least 145 records · Page 8Linked to original sources
PubMed1983

Facet theory applied to the construction and validation of the Aachen Aphasia Test.

The linguistic performance of 120 aphasic patients of the four standard syndromes assessed by the Aachen Aphasia Test (AAT) is analyzed by a nonmetric (ordinal) multidimensional scaling procedure (Smallest Space Analysis, SSA1). The linguistic structure of the test items is characterized within the framework of L. Guttman's facet theory. Three systematic components (facets) are discerned: linguistic modality, unit, and regularity. Properties of the facets as well as their relations are assessed and tested empirically by analyzing the interrelations among different items or sets of items. The spatial configurations obtained by the scaling procedure fit only partially the expectations derived from the facet-theory model. The modality facet was found to have a strong overriding influence on the aphasic test performance. The facets unit and regularity were only found for the most rigorously designed subtests. Written Language and Comprehension. The results suggest the introduction of a new combined facet linguistic complexity which reflects the dependency of the facets regularity and unit.

Adult↗
PubMed1983

A new catheter for peritoneal dialysis (two years of experience with Valli catheter).

The authors analyze the experience of more than 2 yrs of peritoneal dialysis with a new type of catheter. The catheter proposed allows higher flow rates and the maximum outflow of fluid even if malpositioned. The possibility of migration of the catheter is also reduced. The main new feature of this catheter consists in a perforated silastic balloon which protects the distal end of a standard Tenckhoff catheter.

Catheters, Indwelling↗
PubMed1981

Hypertension associated with massive, bilateral, posture-dependent renal dysfunction.

Hippurate function scintiscans were obtained in prone and standing positions in a group of 76 patients with concurrent hypertension and nephroptosis. TWelve of these patients had massive, bilateral disturbance of intrarenal hippurate transport in the standing position; hippurate transport was normal in the prone position. This pattern was present in only three of 120 normotensive patients with nephroptosis. To investigate the importance of nephroptosis, 87 other hypertensive patients were examined. Eighteen of these patients demonstrated posture-dependent tubular dysfunction, but only four had nephroptosis. The results suggest a direct relationship between bilateral posture-dependent tubular dysfunction and hypertension.

Hippurates↗
PubMed1981

[Lower leg fracture--still the most frequent fracture during skiing? (author's transl)].

Evaluation of more than 17,300 injuries caused by skiing in the Black Forest region between 1936 and 1980, shows that there has been a change in the pattern of injuries. However, the most frequent fracture occurring during skiing is, as it has always been, the fracture of the lower leg. Whereas ankle-joint fractures have receded, knee injuries have been increasing. This shows that the type of injuries to the leg have been undergoing a change as a result of modern skiing technique.

Adolescent↗
PubMed1981

Orgotein, a new drug for the treatment of Peyronie's disease.

Twenty-three patients with Peyronie's disease have been treated with the new anti-inflammatory metalloprotein drug orgotein, which exhibits pronounced superoxide dismutase activity. Administration was done into the indurated areas of the penis by a special syringe. Evaluation of signs and symptoms included measurement of the induration size and consistency as well as the degree of the deviation of the penis. The patients responded well to orgotein therapy, especially regarding the loss of pain on erection. On long term results also a diminishment of the induration size and penis deviation on erection was observed; the drug administered intraplaqueally was of outstanding safety.

Anti-Inflammatory Agents↗
PubMed1981

[Endoscopic and histological alterations of the gastric mucosa in patients with chronic renal insufficiency (author's transl)].

Biopsies of mucosa from all regions of the stomach were obtained with endoscopic guidance from two groups of people. One group consisted of 80 patients who suffered from chronic renal insufficiency in various stages and had not yet been dialysed. The other group consisted of 80 healthy individuals. Both groups had the same age distribution. Histological examinations of the biopsies did not reveal significant differences between the two groups. The same was true for macroscopic examinations of stomach and duodenum. Changes indicating a so called "uremic gastritis" were not observed.

Adult↗
PubMed1981

Orgotein--(bovine Cu-Zn superoxide dismutase), an anti-inflammatory protein drug: discovery, toxicology and pharmacology.

Orgotein is the generic name adopted by the USAN Council for drug versions of the Cu-Zn superoxide dismutases. It is obtained from bovine liver by a process sequentially involving heat treatment, enzymatic digestion of other proteins and purification to homogeneity by molecular sieve and ion-exchange chromatography. Orgotein occurs naturally in all mammalian cells, with liver, kidney, and erythrocytes being the richest sources. Prior to employing Orgotein in the clinic, a variety of toxicological and pharmacological investigations in animals have been conducted. The results of these studies are being presented. They indicate that Orgotein possesses a potent anti-inflammatory activity coupled with a pronounced lack of general pharmacological effects, and that its toxicity is of an extremely low order. Orgotein, a major topic of this workshop, is the generic name adopted in 1971 by the U.S. Adopted Names Council for drug versions of the Cu-Zn superoxide dismutases (SOD).

Animals↗
PubMed1980

Vocational rehabilitation in dialyzed patients. A cross-sectional study.

The physicians in charge of 15 German hemodialysis units furnished data on 713 dialysis patients. Data relating to the vocational status were examined for 612 patients aged 60 years or below. It was found that the current working status varies with psychological and social factors. The data show that the vocational status is importantly influenced by the premorbid profession, the level of schooling and by the conditions of the local labor market. With the exception of severe complications or secondary diseases, no relation existed between the somatic state and the current working status. As assessed by the physicians in charge, most dialysis patients were able to work part time, but unable to work full time. Lack of facilities for, or financial disincentives against, part time employment are felt to be the single most important obstacle to vocational rehabilitation of dialysis patients.

Cross-Sectional Studies↗