Search PubMed⌕ Search

Biomedical subjects

W Hohenberger

Publications and source records attributed to W Hohenberger.

At least 235 records · Page 13Linked to original sources

[Rectal prolapse--choice of procedure and minimal invasive possibilities].

Diagnostic and pathomorphological findings support the notion that external and internal rectal prolapse with and without solitary rectal ulcer are merely different stages of one and the same disease. In view of the fact that, in the last resort, the aetiology of this disease remains largely unknown, the differential approach to therapeutic decision-making makes it necessary to give careful consideration to the individual situation of the patient, age, sex, case history and current findings. Although considerably in excess of 100 different surgical techniques have been reported for the treatment of rectal prolapse, only very few have finally been accepted in practice. In very old and high-risk patients, extra-abdominal corrective procedures (Delorme's procedure, peri-anal rectosigmoidal resection) performed under spinal or peridural anaesthesia, are given preference, despite the fact that the recurrence rate and the rate of persistent incontinence is higher than that seen with transabdominal techniques. In the case of younger patients and older patients unburdened by risk factors, the trans-abdominal procedures offer better functional results and lower recurrence rates. Here, anterior and posterior rectopexy and resection of the sigmoid with rectopexy are the most widely practiced procedures. With the further development of minimal invasive surgery, laparoscopic techniques are now also available, with the aid of which anterior and posterior rectopexy and intracorporeal sigmoid resection can be performed safely and reliably. These techniques will very likely further encourage the trend towards transabdominal procedures for the correction of rectal prolapse. These operative procedures may also be indicated in selected cases, in whom conservative treatment of intussusception and/or solitary rectal ulcer has failed.

Adult↗

Selective cytokine release induced by serum and separated plasma from septic patients.

OBJECTIVE: To investigate the activating properties of serum from septic patients on monocytes and the potential effect of plasmapheresis. DESIGN: Prospective controlled study. SETTING: Teaching hospital, Germany. SUBJECTS: 7 Patients with life-threatening systemic inflammatory response syndrome (SIRS) and 4 control patients with serious but not life-threatening conditions. INTERVENTIONS: We measured the amount of mediators released by healthy donor monocytes incubated in serum and separated plasma from septic patients. MAIN OUTCOME MEASURES: Release of interleukin 6 (IL-6), prostaglandin E2 (PGE2), interleukin 1 (IL-1), and tumour necrosis factor (TNF). RESULTS: The serum and separated plasma from infected patients selectively induced the release of IL-6 and PGE2. The mean PGE2 production in serum was 10,895 pg/ml/10(5) cells, and in plasma was 14,023 pg/ml/10(5) cells compared with a control of 0 (p < 0.05). The mean IL-6 production in serum was 4925 pg/ml/10(5) cells and in plasma 4262 pg/ml/10(5) cells compared with a control of 0 (p < 0.05). In contrast, IL-1 and TNF did not seem to be associated with sepsis and were present in small amounts if at all. Additional stimulation with lipopolysaccharide (LPS) increased the serum and plasma induced release of PGE2 and IL-6 (p < 0.05). Serum and plasma from septic patients did, however, selectively reduce the maximum LPS-stimulated release of PGE2 and TNF (p < 0.05) compared with healthy donor monocytes. CONCLUSION: Serum and separated plasma from septic patients contained agents which induced monocytes to release mediators without additional stimulation, and modified their response to LPS. Removing plasma from septic patients may therefore reduce the deleterious effect of the inflammatory response.

Catecholamines↗

[Is surgical therapy of distant metastases of malignant melanoma worthwhile?].

Distant metastases of malignant melanoma are generally considered as incurable related with an unfavourable prognosis. On the basis of our retrospective analysis of surgical treatment, subgroups of patients could be identified showing a significant improvement in survival after complete surgical removal of metastases. In single cases, survival longer than 10 years was observed. The surgical therapy of distant metastases of malignant melanoma is based on a strict patient selection and is only advantageous to those patients whose tumor tissue can be removed completely.

Female↗

[Long-term survival after non-curative therapy of colorectal carcinomas].

In a total of 1073 unradically resected patients (R1/R2) surprisingly we found a group of 31 with a more than 5-year-survival and seven patients living more than 10 years. The prognosis in patients presenting rectal carcinoma was significantly better compared to colon cancer, with a 5-year-survival of 5 +/- 2% compared to 1 +/- 1%. For a long local control of tumor growth in the residual tumor patients, the possibility of irradiation probably in combination with chemotherapy seems to explain these data; but half of our longterm survivors had no additional therapy. The influence of tumorbiological and immunological factors in such patients are of further interest.

Adolescent↗

[Contribution of the clinical cancer register to internal quality assurance in surgical oncology].

Statistically based, continuous quality improvement techniques have been advocated for use in medical settings. Annual reports from the cancer registry database provide most of the information needed to advance improvement or retrogression in the care of cancer patients. The analysis of the frequency of resection, complication rate, mortality rates, and survival rates provides a quality measure for the surgical treatment of cancer.

Databases, Factual↗

[Performance and cost analysis of surgical therapy of stomach carcinoma--results and sequelae].

In order to identify opportunities for cost containment in gastric cancer surgery, and analysis of pre-, peri-, and postoperative cost profiles was performed for 60 gastric cancer patients who underwent curative resections (76.6%), explorative laparotomies (18.3%), and palliative gastrojejunostomies (5%). While pre- and perioperative phases only offer limited opportunities for cost reduction, postoperative complications raised the mean length of hospital stay by 47%, the mean length of intensive care treatment by 865%, and the total treatment costs by 84-248% compared to an uncomplicated clinical course. Pre-, peri-, and postoperative cost-containment efforts must focus on the prevention of postoperative complications.

Costs and Cost Analysis↗

[Curative interventions for recurrence of gastrointestinal carcinomas--incidence and prognosis].

Locoregional relapse following curative resection (= R0) of gastrointestinal cancer occurs in 30% (colorectal carcinoma) and up to 70% (ductal pancreatic cancer) of patients. A potential, complete removal of a tumor recurrence can be achieved, in particular, in the case of colorectal carcinoma. For these tumors and all their locations (loco-regional, metachronic liver and lung metastasis), 5-year survival rates can amount up to 40%. The survival rates of our own patients are presented.

Follow-Up Studies↗

[Oncologic surgery in advanced age: results in colorectal carcinoma].

Over a period of 20 years (1974-1993) 2489 patients under 70 years of age and 1032 patients of at least 70 years of age underwent curative colorectal carcinoma resection. The older patient group was characterized by a significant increase in physical handicaps, concomitant diseases and preoperative complications leading to a rise in postoperative mortality to 7.4% (patients under 70 years of age: 3.0%). Age-corrected 10-years survival rates demonstrate that after a non-complicated postoperative course long term prognosis is excellent even in advanced age.

Aged↗

[Multicenter prospective study of the current status of treatment for bleeding ulcer in Germany].

The current state of ulcer treatment in Germany was analysed in a prospective multi-centre study. It was based on 1139 consecutive patients admitted to the participating hospitals because of upper gastrointestinal bleeding. The source of the bleeding was identified by diagnostic endoscopy in 1075 patients (94%), from a gastric and/or duodenal ulcer in 546 of them (mean age 62 +/- 18 years). Using Forrest's classification, 4% of patients were in bleeding stage Ia, 17% in stage Ib, 16% stage IIa, 30% stage IIb and 33% stage III. An attempt to arrest bleeding through the endoscope was made in 233 patients (43%): more often with tissue-preserving substances (epinephrine +/- NaCl in 36%, fibrin glue +/- epinephrine in 24%) than with tissue-damaging procedures (epinephrine + polidocanol +/- NaCl in 26%, epinephrine + thermocoagulation in 7%). Primary haemostasis was achieved in 219 patients (94%). There was a total of 66 recurrences of bleeding (12%), but the rate was 18% after endoscopic haemostasis. 64 patients (12%) required operative intervention, including initial emergency operations. Severe complications (infections, organic failure) occurred in 82 patients (16%). 114 of the 546 patients were in the high risk group (older than 60 years; high amount of bleeding). Their bleeding recurrence and mortality rates (27 and 22%, respectively) were significantly higher (P < 0.01) than those of the total group. Overall mortality rate was 11% (58 patients). The mortality rate depended on the severity of initial bleeding (26% for Forrest group Ia). After recurrent bleeding the mortality rate was 34% with conservative and 33% with operative treatment. 7% of all deaths were the direct result of bleeding. The following factors prognostically closely correlated with mortality rate: age of patient (P < 0.01); haemoglobin < 8 g/dl on admission (P < 0.05); initial severity of bleeding (Forrest group I; P < 0.05); and recurrence of bleeding (P < 0.001).

Age Factors↗

[Multiple gastric wall abscesses--a rare differential endosonographic diagnosis of submucous stomach tumors].

We report a rare case of a 52 year old patient with multiple gastric wall abscesses. In 1987 a selective proximal vagotomy was performed. Because of non-specific gastric symptoms in 1993 an endoscopy and an endoscopic ultrasound was performed at another hospital which resulted in the likely diagnosis of multiple leiomyomas. Three months later a control endosonography showed three well demarcated submucosal tumors, partly echo-genic, but with an inhomogeneous echo-pattern. A laparotomy and histological examination of the submucosal gastric tumors revealed multiple gastric abscesses with granulomas after selective proximal vagotomy. Difficulties in the differential diagnosis of submucosal gastric tumors arising from this case are demonstrated and discussed.

Abscess↗

[Is acrolentiginous melanoma (ALM) more malignant than superficially spreading melanoma (SSM) at a high-risk site? A matched-pair comparison between 113 ALM and SSM within the scope of a multicenter study].

Even today, the prognosis of acrallentiginous melanoma (ALM) remains a controversial topic. We present a large case study including all known factors relevant for prognosis. 113 ALMs in 3616 melanoma patients were paired as precisely as possible with their twins, i.e. with 113 superficial spreading melanomas (SSM) from a group of 619 SSMs with high-risk location. The ALMs and SSMs were equivalent in tumor thickness, patient gender and mode of treatment. The follow-up period was for at least 5 years. The 5-year Kaplan-Meier survival curve in both groups are identical. The poor prognosis often ascribed to ALM results from the prognostic factor location. ALM should therefore be regarded as acral localized melanoma.

Aged↗

[Prognostic advantage for defined risk groups by lymphocyte dissection. Long-term study of 3,616 melanoma patients].

Nine medical centres with different practices in elective lymph node dissection (ELND) but comparable standards regarding diagnosis, excision of the primary tumour, classification, and follow-up, have collected their data on 3616 patients with primary melanoma of the skin (tumour category pT 2 to pT 4a, N 0, M 0 [UICC 1987] with the aim of producing an unbiased analysis of the prognostic benefit of ELND. The multivariate risk analysis (Cox's proportional hazard model) revealed tumour thickness (Breslow or alternative pT categories), sex, anatomic site of the primary tumour, and ELND therapy ("yes" or "no") as independent prognostic factors. Observed survival curves (Kaplan-Meier) show a significant difference of prognosis with regard to ELND therapy in the following risk groups: women with melanomas over 2.5 to 4 mm thick on head, neck, thorax, and in acral locations; men with melanomas over 1.5 to 4 mm thick on head, neck, thorax, and in acral locations; and finally men with melanomas over 2.5 to 4 mm thick on abdomen and extremities. Further investigations and the discovery of additional prognostic factors would help in more precisely formulation of guidelines for ELND.

Adult↗

[Extremity perfusion in malignant melanoma].

Isolation perfusion was introduced in 1957 by Creech and Krementz for treatment of in-transit metastases from malignant melanoma of the limbs. The isolation of the extremity from the body circulation allows a high concentration of cytostatics without systemic side effects. In combination with hyperthermic tissue temperatures around 41.5 degrees C an additional effect can be expected. Regional metastasizing malignant melanomas with satellites, in-transit or lymph node metastases are generally accepted indications for isolation perfusion. There is still controversy about elective adjuvant perfusion in stage I melanoma. In spite of performing this treatment modality over 40 years in practice there are still many factors under discussion and many problems to be solved. The surgical procedure and techniqual aspects are described in detail. Krementz demonstrated long term survival rates between 19% and 53%. The patients treated in the Surgical Department of the University Hospital in Erlangen since 1975 with satellites and in-transit metastases had a 10-year survival rate of 48%. Considering the historical data of our patients without perfusion with a 10-year survival of 11% there is a highly significant statistical difference. In conclusion isolation perfusion is the therapy of choice in patients with locally metastasized malignant melanoma of the limbs.

Antineoplastic Agents↗

Benefit of elective lymph node dissection in subgroups of melanoma patients. Results of a multicenter study of 3616 patients.

BACKGROUND: The benefit of elective lymph node dissection (ELND) for the treatment of the nonmetastasized malignant melanoma has been assessed differently until today. METHODS: Nine medical centers with a different ELND practice but comparable standards regarding diagnosis, excision of the primary tumors, classification, and follow-up, have collected their data (primarily ascertained prospectively) of 3616 patients of the tumor categories pT2 to pT4N0M0 to produce an unbiased analysis of the prognostic benefit of ELND, and to find the indications for its application. The data are based on patients 70 years of age and younger with a primary melanoma of the skin, who have been followed for at least 4 years (median, 9.6 years). The stratification (according to pT category [alternatively, tumor thickness], sex, anatomic site) was in accordance with the results of the multivariate risk analysis (Cox hazard model). Imbalances of other criteria such as ulceration, type, and age were excluded by chi-square tests of the individual strata. The results are based on the observed survival rates according to Kaplan-Meier analysis of the different strata. RESULTS: A prognostic benefit of the ELND group (improvement of the 5-year survival rate of about 20%) can be claimed for male patients with axial and acral melanomas (excluding lentigo maligna melanoma [LMM] and ulcerated tumors) of the categories pT3a up to pT4a (tumor thickness of > 1.5-4.5 mm, respectively) (P < 0.001). As to the rest of the nonulcerated tumors of male patients, only those of the categories pT3b and 4a benefited from ELND (P < 0.01). A benefit from ELND for women was statistically verified (improvement of the 5-year survival rate of about 5%-10%) only for the subgroup with a tumor thickness > 2.5-5 mm, excluding LMM) (P = 0.016). CONCLUSIONS: This retrospective study strongly suggests the efficacy of ELND in subgroups of melanoma patients.

Adult↗

Diagnostic value of AgNOR staining in follicular cell neoplasms of the thyroid: comparison of evaluation methods and nucleolar features.

The diagnostic value of argyrophil staining of nucleolar organizer regions (AgNOR) was studied in 95 nonneoplastic and neoplastic follicular lesions of the thyroid. Different AgNOR parameters such as number, size, and distribution pattern were determined using digital image analysis. In addition, nuclear and nucleolar size as well as the percentage of nucleoli touching the nuclear membrane (nucleolar margination) were assessed. A stepwise increase in nuclear size and AgNOR counts from normal thyroid tissue to follicular adenoma as well as from differentiated follicular to anaplastic carcinoma was found (mean nuclear area [micron2]/mean AgNOR number per cell: 21.5/1.6 vs. 34.4/3.5 and 45.3/5.0 vs. 66.5/10.8, p < 0.01/p < 0.001). There was, however, no clear separation between these diagnostic groups. In contrast, an almost total discrimination between follicular adenoma and carcinoma was achieved by quantification of AgNORs per tumor cell nucleolus (AgNOR distribution score). In benign adenomas, 3.3% (range, 0-8.8%) of the cells showed nucleoli with at least five AgNOR dots within one focal plane, whereas in follicular carcinomas, the corresponding value was 34.1% (range, 12-75%). Two of four cases of so-called atypical adenomas showed values in the range of benign adenomas, and two were in the range of follicular carcinomas. In comparison with other nuclear and nucleolar parameters, the AgNOR distribution score proved the most valuable diagnostic criterion for the cytomorphological differentiation between follicular adenoma and carcinoma of the thyroid.

Adenocarcinoma, Follicular↗

[Regional hyperthermic perfusion--therapeutic concept and long term results].

Isolation perfusion was introduced in 1957 by Creech and Krementz for treatment of malignancies of the limbs. The isolation of the extremity from the body circulation allows a high concentration of cytostatics without systemic side effects. Regionally metastasizing malignant melanomas with satellites, intransit or lymph node metastases are generally accepted indications for isolation perfusion. There is still controversy about elective adjuvant perfusion in stage I melanoma. Prospective randomized studies must clarify this situation. Krementz demonstrated long-term survival rates between 29% and 52%. Our group of patients with satellites and intransit metastases shows a 10-year survival rate of 48%. Considering the historical data of our patients without perfusion and with a 10-year survival of 11%, there is a highly significant statistical difference. In conclusion, isolation perfusion is the therapy of choice in patients with locally metastasized malignant melanoma of the limbs.

Antineoplastic Agents↗

[Pelvic multivisceral resection from the viewpoint of surgery].

Even rectal carcinomas, carcinomas of the female genital tract, and retroperitoneal sarcomas of the pelvis with invasion of adjacent organs are potentially curable by extending the operation to the relevant structures. In the Surgical Department of the University of Erlangen, 1535 patients with a first diagnosis of rectal carcinoma were treated from 1978 to 1988. Among these patients, 97 multivisceral pelvic resections (patients with distant metastases excluded) were performed. True tumor invasion had occurred in 48%, the others were operated on for inflammatory adhesion. In 54 patients, the anal sphincter was preserved. Postoperative mortality was 7%. The 5-year survival of those patients with tumor invasion of adjacent organs and R0-resection (n = 26) was 32%. Excluding the five patients with a tear or incision of the tumor (n = 5), the 5-year survival of the remaining patients was 44%. One patient who was operated on for a leiomyosarcoma of the rectum with a multivisceral resection of the rectum, prostate, and urine bladder is still alive 9 years after the operation without recurrence. The history of this patient argues for pelvic exenteration also in males, if a R0 resection can be performed.

Female↗