Search PubMed⌕ Search

Biomedical subjects

W Hoffmann

Publications and source records attributed to W Hoffmann.

At least 217 records · Page 12Linked to original sources
PubMed1985

[Developmental dysphasia and the use of symbols in play].

In the present study symbolic play behavior was examined in eight dysphasic children and eight mentally retarded children matched for expressive language ability. Significant correlations between symbolic play and expressive language ability were found for the mentally retarded children but not for those of normal intelligence with dysphasia. Consequently, the developmental disorder of the dysphasic children cannot be attributed to a generalized deficit in representational symbolic ability.

Aphasia↗
PubMed1985

[Pharmacologic studies on the effect of 3-carbethoxyamino-5-dimethylamino-acetyl-iminodibenzyl hydrochloride (Bonnecor, AWD 19-166, GS 015) on the vegetative and central nervous system].

The substance GS 015 was tested as to its influence on the vegetative and the central nervous system. The total of side effects is low. In spite of the structural resemblance the aspect of action does not correspond to that of tricyclic psychopharmaceutical agents. Pharmacologically relevant doses bring about: local anaesthesia, musculotropic spasmolysis, inhibition of the serotonin-induced oedema, antiulcerative effect, intensification of the toxicity of amphetamine. The results do not oppose to a clinical use.

Animals↗
PubMed1984

Amino acid sequence of the carboxy-terminal part of an acidic type I cytokeratin of molecular weight 51 000 from Xenopus laevis epidermis as predicted from the cDNA sequence.

The DNA sequence of a clone from a cDNA library made from Xenopus laevis skin is described. This sequence represents the 3'-terminal end of an mRNA which codes for an epidermal cytokeratin polypeptide of mol. wt. 51 000 of the acidic (type I) subfamily as identified by hybridization-selection of mRNAs, followed by gel electrophoretic identification of the polypeptides synthesized by translation in vitro. The partial amino acid sequence of the amphibian cytokeratin shows strong similarity to type I cytoskeletal keratins from human (mol. wt. 50 000) and murine (mol. wt. 59 000) epidermis. In the non alpha-helical tail region the human and the non-mammalian (Xenopus) keratins are more similar to each other than to the murine protein, indicating that the former are equivalent cytokeratin polypeptides and belonging to a special subclass of type I keratin polypeptides devoid of glycine-rich regions in the carboxy-terminal portion. The evolutionary conservativity of the genes coding for cytokeratins is discussed.

Amino Acid Sequence↗
PubMed1984

Reduced side effects by low dose of acetylsalicylic acid (ASA) in patients with myocardial infarction; estimations of serum thromboxane B2 and PGF2 alpha.

In a secondary prevention study 867 male and female patients with myocardial infarction (MI) were divided 3 weeks after onset of MI into 4 treatment groups: I - 273 patients received additionally to their common medication 1000 mg ASA/d; II - 313 patients got 60 mg ASA/d; III - 208 patients 30 mg ASA/d resp.; IV - 73 patients received no ASA administration due to ASA contraindications. One year after onset of MI the following parameters were checked: mortality, malignant arrhythmia, exercise tolerance, gastrointestinal symptoms and hemorrhage as typical side effects of ASA, formation of thromboxane B2 and PGF2 alpha in clotting whole blood. The low dose of 30 mg ASA/d reśultes in a clear reduction of ASA side effects (6,4% of patients with symptoms) in comparison to group I (15,9% of patients with symptoms), in a tendency to decreased mortality, and in unchanged frequency of malignant arrhythmias resp. Concerning the maximum exercise tolerance no significant difference could be observed in all 4 groups investigated. Estimations of serum thromboxane B2 by radioimmunoassay and gas chromatography revealed strong inhibitions of the thromboxane formation in all patients with ASA administrations; even the low dose of 30 mg ASA/d decreased thromboxane B2 by more than 95%.

Adult↗
PubMed1984

[Learning behavior in rats after chronic haloperidol treatment].

The effect of 3 week chronic haloperidol treatment has been investigated in rats by retention of active avoidance (pole jumping). In the period of dopaminergic supersensitivity, i.e. after withdrawal of haloperidol, pretreated rats showed a better retention of the learned reaction than controls. The results demonstrate that the neuroleptic-induced supersensitivity enhanced not only the spontaneous and stimulated locomotor activity, but also improved the retention of an active avoidance reaction.

Animals↗
PubMed1984

[Long-term ECG findings in children with healthy hearts].

Ambulatory monitoring of the ecg was performed in 100 healthy children aged between 6 and 16 years for the period of 24 hours. On the same day all children studied had normal standard 12 lead ecg. The maximal heart rates ranged from 96 to 176 beats and minimal rates were 36 to 79 beats per minute. Sinus arrhythmia, what we called variation of frequency, was found very often (55 per cent). A wandering atrial pacemaker occurred in 47 per cent, while true intermitted junctional rhythm (duration more than 3 beats) was seen in 20 per cent. Premature atrial beats we have seen in 11 per cent, ventricular extrasystoles occurred in 20 per cent. Sinus bradycardias were found nearly almost during sleep with a rate under 40 beats per minute in one child and under 60 beats per minute in 49 per cent. We could not find sinuatrial blocks at all. AV-Blocks I0 and II0 were seen in two children, respectively. There was a clear advantage in the diagnostic of arrhythmias with using the 24-ecg-ambulatory monitoring in comparing with the standard ecg. Further advantage of this method is it's non invasive character.

Adolescent↗
PubMed1983

Biosynthesis of caerulein in the skin of Xenopus laevis: partial sequences of precursors as deduced from cDNA clones.

The decapeptide caerulein represents one of the main constituents of the skin secretion of Xenopus laevis. Total mRNA was isolated from skin, transcribed into cDNA and inserted via GC-tailing into the plasmid pUC8. Among the transformants, 300 clones were selected at random and screened with a cDNA primed with the synthetic deoxynucleotide d(AGTCCATCCA), which is complementary to the mRNA region coding for the fragment Trp-Met-Asp-Phe of cerulein. Of nine strongly hybridizing clones, three were sequenced and these were found to contain inserts with very similar nucleotide sequences. The cloned cDNAs code for parts of two different caerulein precursors. These contain one or two copies of caerulein and five additional amino acids located between pairs of arginine residues. The extra glycine at the carboxy terminus is considered to serve as the signal for amidation, while the tetrapeptide Phe-Ala-Asp-Gly, linked to the amino end of caerulein in these precursors, must be cleaved by an unusual processing mechanism.

Amino Acid Sequence↗