Search PubMed⌕ Search

Biomedical subjects

W Hirsch

Publications and source records attributed to W Hirsch.

97 records · Page 6Linked to original sources
PubMedDate not supplied

[Ultrasound morphologic changes in periventricular leukomalacia].

Therapeutic advances in neonatology cause fewer hypoxic conditions. In relation with this we observe fewer high grade brain haemorrhages. Therefore, ischemical brain changes through brain oedema (12%) and resulting colliquation necroses become the focal point of diagnostic and therapeutic work. 7.3% of intensively treated neonates showed the sonographic picture of a periventricular leucomalacy (PVL). The polycystic areas can be seen on the eight day after birth at the earliest and at six months they turn into a glia scar which is not very obvious on the sonograph. We found a relation between beta-mimetic tocolysis, hypocapnia and the development of a PVL. We were not able to prove statistically a connection with premature birth.

Birth Weight↗
PubMedDate not supplied

Asymmetrical, reciprocal translocation (45,XX,tdic(9;17) (p21;p12).

A nine-month-old girl with dysmorphic features, congenital heart disease and chromosomal mosaicism is reported. Approximately one-half of the cells (lymphocytes and fibroblasts) showed a normal karyotype 46, XX, the other half a dicentric translocation chromosome. Using the G-band technique, the dicentric chromosome was identified as a 9/17 translocation chromosome. Both centromeres of the translocation chromosome could be stained to the same degree, using the C-band technique. The centromere region of chromosome No. 9 was in addition demonstrated, by using the Giemsa 11 technique.

Abnormalities, Multiple↗
PubMedDate not supplied

Acute cerebellitis: case report and review.

We report a case of acute cerebellitis in a 7-year-old male presenting with headache, vomiting, ataxia and life-threatening hydrocephalus requiring emergent placement of an external ventricular drain. Unlike earlier reported cases which did not provide radiographic correlation of this disease, this report documents changes in the cerebellum with serial magnetic resonance and computer tomography scans. The signs, symptoms and differential diagnosis of this rare, self-limiting condition are briefly discussed.

Cerebellar Ataxia↗
PubMedDate not supplied

Chronic acquired hepatic failure: MR imaging of the brain at 1.5 T.

The results of MR imaging of the brain at 1.5 T in 42 adults with non-Wilsonian chronic hepatic failure are reported. T1-weighted images demonstrated increased signal in the globus pallidus in 30 patients and in the putamen in 21, while T2-weighted images demonstrated no corresponding alteration in signal intensity. Symmetric low intensity in the central portion of the globus pallidus on spin-density and T2-weighted images in two patients correlated with regions of calcification on CT scans. Increased intensity on T1-weighted images also occurred in the mesencephalon surrounding the red nucleus (17/42) and in the quadrigeminal plate (4/42). Three patients demonstrated increased intensity in the pons on T2-weighted images unassociated with clinical brainstem dysfunction. Increased intensity on T1-weighted images was seen in the anterior pituitary in 28 of 35 patients. Alterations in signal intensity were not demonstrated in the cerebral cortex or cerebellum. MR findings did not correlate with laboratory indices of hepatic or thyroid function, with histologic liver diagnosis, or with neurologic status at the time of MR evaluation. Increased signal intensity in the basal ganglia, pituitary gland, and mesencephalon surrounding the red nuclei is characteristic of chronic hepatocellular dysfunction. Deposition of an as yet unidentified paramagnetic substance or altered intracellular water relaxation associated with the proliferation of astrocyte cytoplasmic organelles is postulated as the likely mechanism for this previously undescribed MR manifestation of chronic acquired hepatic failure.

Brain↗