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Biomedical subjects

W Henry

Publications and source records attributed to W Henry.

31 records · Page 2Linked to original sources

Cellulitis: initial management.

Although Staphylococcus aureus and Streptococcus pyogenes cause the majority of cellulitis, recent studies have shown a significant role for Hemophilus influenzae in facial, and less frequently, nonfacial infections. We devised an algorithm for the initial management of cellulitis based on our previous investigations showing a correlation of this organism with fever, leukocytosis, and facial involvement. Children were divided into four groups characterized as follows: Group I - extremity, temperature less than 38.5 C; Group II - extremity, temperature greater than 38.5 C, WBC less than 15,000/cu mm; Group III - extremity, temperature greater than 38.5 C, WBC greater than 15,000/cu mm; and Group IV - facial. Forty-five children were successfully followed. There were 34 in Group I, five in Group II, one in Group III, and five in Group IV. Two children in Group IV and the only child in Group III had H influenzae, recovered form the blood (3) or a direct aspirate (1). All three were febrile, with a range of 39.5 C to 40.1 C and has an elevated white blood cell count with a range of 19,200/cu mm to 26,000/cu mm. With one exception, children with cellulitis not due to H influenzae did not have both fever and leukocytosis. This algorithm allows the clinician to identify children with H influenzae cellulitis who are at risk for septic complications while minimizing unnecessary diagnostic or therapeutic interventions.

Adolescent↗

Evaluation of cardiac function in patients with thalassemia major.

The application of noninvasive techniques to the evaluation of cardiac function in iron overload has identified a high incidence of abnormalities in asymptomatic patients prior to the onset of overt cardiac deterioration. Of the tests we have used, radionuclide cineangiography appears to be the most sensitive because it can be conveniently applied during the physiological stress of exercise. Other tests of cardiac function that include stress are also likely to be more sensitive than resting measurements of cardiac function. Systematic application of these techniques to the study of patients on iron chelation therapy should results in an early determination of the efficacy of such treatment.

Adolescent↗

Hepatoma visualization with Tc-99m pyridoxylidene glutamate.

Tc-99m sulfur colloid is concentrated in Kupffer cells of the liver, whereas the new biliary agents are processed by hepatic parenchymal cells. A case of primary hepatocellular carcinoma, appearing as a defect on sulfur-colloid liver scan and visualized on a biliary scan, is presented. The possible role of biliary scanning in the evaluation of a defect on sulfur-colloid liver scan is discussed.

Aged↗

In vitro studies on the use of penicillamine with tartar emetic against Schistosoma mansoni worms.

In vitro studies were carried out to test Sb125 tartar emetic (T.E.) in concentrations of 75, 100, 125, 150 and 200 mug/ml of rabbit serum and these concentrations together with penicillamine in ratios ranging from 1:1 to 1:6 for their effect on the motility and antimony uptake by Schistosoma mansoni worms. The motility was observed microscopically every half hour for six hours and the Sb125 content was measured by a scintillation counter at one hour intervals for five hours. Results indicate that the ratio in which penicillamine is used with T.E. is very important. The antimony uptake by the worm is reduced, and the onset of T.E. action is delayed when it is used with penicillamine in a ratio exceeding 1:2.

Animals↗

Environmental influences on the failure to drink in inbred rats with an ethanol preference.

To investigate the environmental influences on the initiation of voluntary consumption of 10% ethanol (EtOH) in rats with differing genetic susceptibility to excessive EtOH consumption, Maudsley reactive (MR/Har) and nonreactive (MNRA/Har) inbred rats were observed in different types of caging environments. Singly housed male and female rats of both strains living in Observational (O) cages drank markedly less EtOH during 3 weeks of two-bottle choice than did rats living in standard-control (C) individual cages. When male rats had a preexisting moderate or heavy pattern of EtOH intake (manipulated through prior EtOH experience), moving to the O cage did not reduce EtOH intake. To investigate the nature of the above cage effect (the reduced initiation of EtOH consumption), we compared the manner in which food had been distributed (traditional food hopper in C cages versus loose distribution in O cages) independently of cage type. The results showed that MR/Har male rats that obtained food through a hopper in both O or C cages drank significantly more EtOH than rats that had food loosely distributed in the O or C cages. The results suggest that differences in the mode of food procurement and caging can play a large role in whether the phenotype for excessive EtOH intake is expressed in the acquisition of an EtOH preference in genetically vulnerable rats.

Alcohol Drinking↗