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Biomedical subjects

W Helbig

Publications and source records attributed to W Helbig.

At least 73 records · Page 4Linked to original sources
PubMed1979

[Iliac crest biopsy findings in malignant non-Hodgkin lymphoma].

Issuing from the clinico-prognostic importance of the classification after Kiel of the malignant non-Hodgkin-lymphomas the results of the attempt of a reclassification of positive bioptic findings of the iliac crest judged according to the former German nomenclature are described and discussed after the Kiel classification. In the total material of 725 biopsies 76 positive findings of the marrow were stated in malignant non-Hodgkin-lymphomas, which at 67.1% consist of such with a lower and at 32.9% of such with a high degree of malignity, in which case a strong decrease of the formerly diagnosed CLL is to be seen after reclassification, whereas the immunocytomas render the by far largest proportion. The former malignant reticuloses disappear per definitionem after reclassification and, as it was expected, are broadly distributed. In 112 biopsies which were performed on account of the suspicion of an affection of the marrow in malignant non-Hodgkin-lymphomas the 76 positive findings correspond to a frequency of 67.9%, which, however, must critically be judged, since the case in question are very selected numbers of patients.

Biopsy↗
PubMed1979

[Diagnosis and therapy of acute leukemia in adults].

Apart from the most essential aspects of the diagnosis and differential diagnosis of acute leukaemias concerning the early diagnosis of leukaemias the author deals with the so-called praeleukaemia. On the basis of a survey of international literature the modern polychemotherapy and its successes are characterized as well as the necessary supportive haemotherapy) are dealt with. Despite the improved frequency of remissions the survival time of acute leukaemias could only little be prolonged, that of the first remission could not be prolonged. Perhaps it is possible by an in future improved immunotherapy and by allogenic transplantation of the bone-marrow after supralethal total body irradiation to set new measures in the treatment of acute leukaemias.

Adult↗
PubMed1979

[Valuation of autologous bone marrow transplantation in radio- and chemotherapy of malignant tumours (author's transl)].

This paper discusses the prerequisites of bone marrow autotransplantation performed as part of cancer therapy, the emphasis being on the condition of the patient, the facilities available to the institution for the treatment of cancer patients, the biology of the tumour, and the present possibilities of carrying out what is called superdose cancer therapy. The practical performance of a bone marrow autograft is based upon the withdrawal of bone marrow with indefinite vital stem cell preservation by deep cooling at a time when the tumour has not yet led to bone marrow metastasizing. The conserved bone marrow is used, in subsequent radiological and/or cytostatic superdose therapy, as a reserve in the case of extreme damage to hematopoiesis. The discussion of the current status of this method and the prospects for its general use reflects the whole spectrum of the problems associated with the most favorable procedure to be used, the type of superdose therapy to be employed, the time of regrafting, and the accurate assessment of the results obtained.

Bone Marrow Transplantation↗
PubMed1978

[Renal anemia and its modification by chronic hemodialysis].

The renal anaemia is characterized by a decreased new formation of erythrocytes (deficiency of erythropoetin), by haemolysis (uraemic-toxic influences) and by iron deficiency (decreased resorption of iron, blood losses, infectious-toxic component). In long-term haemolysis the iron deficiency increases, in most cases the haemolysis a little decreases, and a deficiency of erythropoietin is not to be established. However, a slight deficiency of folic acid is frequently observed. Apart from the reduction of the retention of substances normally contained in the urine the therapy consists in iron doses and slight doses of folic acid. Only occasionally blood transfusions are necessary.

Anemia, Hemolytic↗
PubMed1978

[Pregnancy anemias].

After introductory remarks on the physiology of blood during pregnancy the authors enter the two most frequent anaemias of pregnancy, which are evoked by iron deficiency and infection, as well as the megaloblastic, which are evoked by deficiency of folic acid--more infrequently also by deficiency of vitamin B12. The diagnostic and therapeutic principles are described in detail. It is only in short referred to the very rare haemolytic and toxic farms of anaemia, it is generally renounced to describe the haemorrhagic anaemia. A prophylaxis of the anaemia of pregnancy is intensely recommended.

Anemia↗
PubMed1978

[Supportive hemotherapy in anemias].

The substitution of blood and erythrocytes, respectively, has to be performed as an aimed supportive haemotherapy according to measure. Therefore full blood is indicated only in loss, otherwise only concentrates of erythrocytes may be transfused, in order to exclude side-effects as a potential danger. The latter should above all produced buffy-coat-free. Washed preparations of erythrocytes should be used only in such a case, when there are present clear clinical demands, such as transfusion reactions which can otherwise not be removed, and which for their part limit the success of the transfusion. The practically plasma-free concentrates of erythrocytes which are extremely poor in alloantigens and preserved at deep temperature should at present be used for reasons of capacity only in persons who are potentially to be transfused many times, above all in recipients of grafts.

Anemia↗
PubMed1978

[Catamnestic studies on infections in granulocytopenias].

Granulocytopenias in insufficiencies of the bone marrow, haemoblastoses and other basic diseases led to an increased endangering by infections and frequency of infections. As a rule, here was decisive the scope of the decrease of the granulocytes, measured at the morbidity by infections, the degree of severity of the infection, the frequency and the duration of fever episodes. Despite improved possibilities of antimicrobial treatment the complications by infection in granulocytopenias increased, so that the prophylaxis of the infection is of particular significance.

Agranulocytosis↗
PubMed1978

[The number of salivary corpuscles in healthy subjects and in patients with periodontal disease].

Using a standardized, well reproducible method, the authors determined the number of salivary corpuscles in 174 healthy subjects (1,400 to 2,000/microliter) and 109 patients with periodontal disease (5,300 to 7,800/microliter). The statistical analysis revealed a highly significant difference between the two groups. There was a positive correlation between the number of salivary corpuscles and periodontal disease indices.

Cell Count↗
PubMed1978

[Theoretical, methodological and clinical aspects of the growth of granulopoietic cells in agar culture].

Haematopoietic stem cells are capable of developing colonies of differentiated granulocytes in a semi-stable agar environment under corresponding experimental conditions. Number and size of aggregations developing from a single stem cell in each case called "in culture Colony Forming Unit (CFU-c)" enable conclusions to be made about the functional ability of the cultivated human or animal bone marrow. The method is applied in investigating the kinetics in the haematopoietic system and, in addition, it is used for diagnostics, therapy and control of the course in haematological diseases as well as to check the proliferous ability of cryopreserved bone marrow cells. As to the standardization of the procedure the instability of the active principle of the foetal calf serum as well as the essential colony stimulating factor represent limiting items at present.

Agar↗
PubMed1978

[Phagocytic granulocyte function in hemoblastoses].

Judging from the spontaneous NBT reduction, the indices of phagocytosis and NBT, there is a moderate, but statistically significant diminution of these parameters in leukaemia and malignant lymphoma including plasmocytoma. Moreover, further diminutions could be identified during the acute stage of the disease (first diagnosis or recidive) in acute leukaemia and lymphogranulomatosis, but not for chronic myeloic leukaemia.

Acute Disease↗
PubMed1977

[Basic principles of anemia diagnosis].

Anaemias are diseases, which are characterized by a decreased concentration of haemoglobin and erythrocytes in the blood. They can be classified on the basis of etiopathogenetic and laboratory-diagnostic principles. From this results a differentialdiagnostic model of thinking, which may relieve the differential diagnosis on the basis of anamnesis and careful clinical examination and with aimed use of laboratory primary and additional examinations. It is particularly to be taken into consideration that anaemias very often may be complication or symptom of most various basic diseases. To combat an anaemia "differential-diagnostically" ex juvantibus by means of iron and/or vitamin B12, must be generally refused.

Anemia↗
PubMed1977

[Diagnosis and therapy of megaloblastic anemias].

In most cases megaloblastic anaemias are the sequel of a deficiency of vitamin B12, more infrequently of a deficiency of folic acid of different etiology. Oriented to frequency and anamnesis the diagnostics follows the leading symptoms of pernicious anaemia (straw colour, glossitis, achlorhydria) and on the basis of special findings in the peripheral blood (hyperchromacia, megalocytosis, much decreased number of reticulocytes, increased iron and bilirubin level) it leads to the proved suspicion of a megaloblastic anaemia. This suspicion is ascertained by the investigation of the bone-marrow, with the help of aimed investigations the anaemia is further clarified differential-diagnostically. An unclear anaemia should not be treated ex juvantibus with vitamin B12 and/or folic acid. The therapy, always taking into consideration a possible basic disease, is carried out by parenteral application of vitamin B12, possibly in form of hydroxocobalamine or by folic acid. In persisting disturbance of the resorption of vitamin B12 on account of the threatening complication of a funicular spinal disease the long-term therapy must never be interrupted, unless in normal haematological findings.

Anemia, Macrocytic↗
PubMed1977

[Anemia in chronic hemodialysis].

On the basis of general haematological, clinicochemical, cytomorphological, cytochemical and nuclearmedical investigations the anaemia of chronic haemodialysis can be considered as a renal anaemia modified by a permanent dialysis. It is less characterized by lack of erythropoietin, but more by a strong lack of iron, moderate haemolysis and slight deficiency of folic acid. After gradual diagnostics the substitution treatment with iron is absolutely necessary, medication of folic acid should be attempted. A permanent therapy with 80-120 mg of iron weekly administered parenterally can be successfully performed and 10-15 mg of folic acid daily, which will markedly lower the rate of transfusion.

Anemia↗
PubMed1976

[Assessment of granulopoietic function reserve of the bone marrow by means of the Pyrecol-test in granulocytopenias, immature-cell leukoses and patients under antineoplastic agent therapy].

By injection of the irritating substance Pyrecol the granulopoietic reserve of the function of the bone marrow can be judged. In normal test persons the result is after 8 hours an increase of leucocytes to 176%, when the granulocytes increase to 216%. On the other hand the rate of increase in patients with undifferentiated cell leucosis is statistically highly significantly lower (2alpha = 0.01) with 115 or 132%, respectively. A higher ejection function of the bone marrow correlating with the clinical improvement is to be found after a successful therapy with cytostatics. By this the test informatively contributes to dosage and effectiveness of the therapy with cytostatics and to the course of the disease. In 6 patients with granulocytopenia of unclear genesis examined in the result of the Pyrecol-test 5 passager granulocytopenias with favourable clinical course unambiguously distinguished themselves from a pan-myelophthisis with exitus letalis. The test is easily to be performed and has no essential concomitant a-pearances. By the integral functional evidence it represents a rational supplementation of the locally demarcated morphological substrate of the sternal puncture or bone marrow biopsy, respectively.

Adolescent↗
PubMed1976

[New diagnostic and therapeutic aspects of lymphogranulomatosis].

The prognosis of lymphogranulomatosis has improved by the considerably improved diagnostics as well as the modern radiological and polychemo-therapeutical methods. Today the average survival time is between 4 and 5 years. But survival times up to 15 years and more are described. Apart from the early diagnosis, into which according to the opinion of many internal specialists the otorhinolaryngologists must be included more than it was hitherto the case, nowadays the modern radiotherapy with explorative laparotomy and splenectomy and the perhaps following combination chemotherapy might bring a further improvement. Growing age, histological types with a small number of lymphocytes, too late diagnosis and deficient control decrease, however, signigicantly the chances of surviving. Certainly, in future more modern methods of chemotherapy must be used. The same applies to the treatment of the developing immunoinsufficiency and the eventual further performance of the cytostatic treatment in the sense of a maintenance therapy. From the modern point of view the way taken might lead to still higher survival times. In as far immunotherapy will be of greater importance already in the next years is not yet to be decided at present.

Antineoplastic Agents↗
PubMed1975

[Therapy and prognosis of autoimmune hemolytic anemia].

Of 48 patients with autoimmunohaemolytic anaemia who were treated in our clinic during the last 10 years 13 could fully be cured, 20 exhibited a satisfying improvement, 7 remained without improvement and 8 died (3 of them of the basic disease). The results obtained allow the conclusion that the therapeutic use of corticosteroids, particularly at the beginning of the treatment as well as in the acute haemolytic attack is justified. Cytostatics, however, are especially suitable for long-term therapy, whereas splenectomy should be performed when no sufficient therapeutic success was achieved and in special cases. Under optimal therapy and repeated control the prognosis is to be regarded as favourable. For this reason treatment and further care by a haematological centre are demanded, since in such a facility are the most favourable conditions for the best care of the patients with autoimmunohaemolytic anaemia.

Adult↗