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Biomedical subjects

W Hall

Publications and source records attributed to W Hall.

At least 181 records · Page 10Linked to original sources
PubMed1992

Development of a short 'readiness to change' questionnaire for use in brief, opportunistic interventions among excessive drinkers.

Excessive drinkers (141) identified in medical settings who were not seeking help for an alcohol problem completed a questionnaire based on Prochaska and DiClemente's stages of change model. Principal components analysis revealed a clear factor structure corresponding to the 'precontemplation', 'contemplation' and 'action' stages of change. On this basis, a 12-item 'Readiness to change' questionnaire was developed with satisfactory psychometric properties. As predicted, scale scores on adjacent stages of change showed significantly higher inter-correlations than scores on non-adjacent stages. Concurrent validation by comparison with subjects' choices of cartoons depicting each of the stages of change and with screening questions regarding aspects of drinking behaviour was moderate to very good. The questionnaire provides a short and convenient measure of readiness to change which may be used in conjunction with brief, opportunistic interventions with excessive drinkers.

Adult↗
PubMed1992

A comparison of women seeking drug and alcohol treatment in a specialist women's and two traditional mixed-sex treatment services.

The paucity of research on the treatment needs of women with substance abuse problems has been a serious impediment to the development of empirically validated treatment programmes. Women continue to be seriously under-represented as research subjects and clients of treatment services. This study compares the characteristics of 80 women attending a specialist women's treatment service with those of eighty women attending two traditional mixed-sex treatment agencies. Women attending a gender-sensitive service were significantly more likely to have dependent children, to be lesbian, to have a maternal history for drug or alcohol problems and to have suffered sexual abuse in childhood. These results suggest that gender-sensitive treatment services may be recruiting women who might not otherwise have sought treatment for their substance dependence problems.

Adolescent↗
PubMed1992

The public perception of the risks and benefits of alcohol consumption.

A survey of the community was undertaken in August 1989 to assess the public's perception of the risks and benefits of alcohol use, and their understanding of recommended levels of safe alcohol consumption. A household sample of 500 men and women (18 to 65 years) in metropolitan and rural New South Wales were asked their opinions about the risks and benefits of alcohol use, the health and social consequences of 'drinking too much', and the number of standard drinks that would produce a low, medium and high risk to the health of an adult man and woman. The major perceived benefits of alcohol use were relaxation and medication; the major health and social problems attributed to alcohol abuse were brain and liver damage, and domestic violence and family problems. The quantities of alcohol which respondents thought could be consumed with a 'low' risk to health were close to National Health and Medical Research Council recommended levels of safe consumption.

Adult↗
PubMed1992

Estimates of the number of injecting drug users in a defined area.

Three estimates of the number of injecting drug users residing within the Eastern Sydney Area Health Service (ESAHS) were obtained by applying the capture-recapture technique to data from three reliable sources, specifically, Methadone Services, the Bourke Street Drug Advisory Service and the Albion Street Clinic. The obtained estimates were 3449, 3046 and 1103 respectively. Statewide methadone statistics were also used to obtain an estimate of 15,082 injecting drug users in New South Wales. This estimate was close to the linearly projected estimates (14,274 and 14,416) from two previous studies. Estimates based upon the methadone statistics indicate that approximately 23% of injecting drug users in New South Wales reside within the ESAHS. A sensitivity analysis was performed to assess the effects on the estimates of the likely violation of the closed population assumption.

Ambulatory Care↗
PubMed1992

Anxiety, depression and HIV related symptomatology across the spectrum of HIV disease.

Levels of anxiety and depression were assessed for 207 HIV seropositive homosexual/bisexual men (AIDS = 34, ARC = 72, asymptomatic HIV infection = 101), and 36 seronegative controls. Lymphocyte subset enumeration, history of opportunistic infections, and occurrence of HIV-related symptoms were recorded at the time of assessment. No differences between groups were found on age, educational level, state/trait anxiety or depression scores. Neither the number of symptoms reported, their duration, severity, frequency of occurrence, nor the proportion of patients who reported a specific symptom was different between the three HIV seropositive groups. Severity of anxiety and depression was related to the magnitude of symptomatology, but not associated with either degree of immunodeficiency, number of opportunistic infections or diagnostic group. Principal component analysis extracted five symptom factors (cognitive, affective, psychosocial, neurological and physical), none of which predicted state anxiety scores. However, affective and psychosocial symptom factors predicted trait anxiety and depression scores. The results indicate that ratings of anxiety and depression are independent of stage of HIV infection, may be in part mediated by constitutional and physical symptoms of HIV disease, but are primarily associated with the presence of psychological and psychosocial symptoms.

AIDS Dementia Complex↗
PubMed1992

Hypermedia in biomedical education: a case study.

The origination, development and application of a hypermedia system for use in the life sciences is described. Implemented in the Apple Macintosh HyperCard environment, the project has been designed to make use of commercially produced laser discs as visual archives and has included the production of authoring and navigational tools. We report here on our experience in authoring stacks for undergraduate teaching, monitoring of student use and assessment of effectiveness as a self-teaching resource. Future developments and applications within the biomedical sciences are discussed.

Biological Science Disciplines↗
PubMed1991

Effect of amphetamine on cerebral blood flow and capillary perfusion.

The purpose of this study was to determine the cerebral regional microvascular and vascular responses to amphetamine sulfate at a dose (5 mg/kg) known to affect neuronal function. Cerebral blood flow (14C-iodoantipyrine method) and percent of perfused capillaries (fluorescein isothiocyanate-dextran and alkaline phosphatase staining method) were determined during control and after intravenous administration of amphetamine in conscious Long-Evans rats. Amphetamine caused an increase in blood pressure (34%) and heart rate (31%). There was a significant increase in averaged cerebral blood flow from 98 +/- 8 to 166 +/- 9 ml/min/100 g after amphetamine. This flow increase was significant in the cortex, basal ganglia, pons and medulla, however the increase was not significant in the hypothalamus. In control rats, there were approximately 325 +/- 17 capillaries/mm2 of brain tissue and 52 +/- 1% of them were perfused. Amphetamine increased the percent perfused significantly to 72 +/- 1% in all examined regions. There was a similar significant increase in the percent of perfused cerebral capillary volume fraction. There were both vascular and microvascular responses to amphetamine, increasing cerebral blood flow as well as reducing the diffusion distance for oxygen.

Amphetamine↗
PubMed1991

Anaplastic thyroid carcinoma: cytomorphology and clinical implications of fine-needle aspiration.

Four cases of anaplastic carcinoma of the thyroid were diagnosed in 1,519 thyroid aspirates. All patients had unilateral or diffuse nodular enlargement of the thyroid. One patient had a concurrent grade 1 mucinous carcinoma of the ovary. Cytologically, the neoplasms were characterized by pleomorphic giant or spindle cells with multilobulated, single or multiple nuclei. The chromatin pattern was clumped with prominent parachromatin clearing, and there were multiple prominent nucleoli. Associated papillary and follicular structures were recognized in two aspirates. All cytologic preparations were considered diagnostic of malignancy. Examination of histologic material revealed the same elements identified cytologically on the aspiration smears. Three patients died shortly after diagnosis due to massive local tumor growth in the neck. One patient, who received radiation therapy, had a prolonged survival of 30 mo, but died then of local neck recurrence. The cytologic features of anaplastic carcinoma parallel their histologic appearance. Histologic confirmation of cytologically diagnosed anaplastic carcinoma is not necessary.

Adult↗
PubMed1991

Hyperactivity and the fragile X syndrome.

Workers who have claimed an association between Fragile X [fra(x)] Syndrome and Hyperactivity and aggressive behavior have done so despite the lack of controlled studies using standard diagnostic criteria. Accordingly, we provided a controlled test of the hypothesis that individuals with the fra(x) Syndrome are more hyperactive and have more symptoms of aggression than other mentally retarded individuals. The test formed part of a study to assess autistic behavior in fra(x) individuals. A sample of fra(x) individuals was obtained from the register of a clinical genetics unit and individually matched for age, sex, and IQ with mentally retarded individuals selected from assessment centres. Forty-five pairs of fra(x) cases and control individuals were compared on criteria which reflected DSM-III concepts of hyperactivity and on criteria reflecting aggressive behavior. The comparison failed to find a higher prevalence of these symptoms in the fra(x) group. An analysis of the study's statistical power suggested that it is unlikely that the investigation failed to detect a large to medium difference between fra(x) individuals and control individuals in the symptoms investigated.

Adolescent↗
PubMed1991

Issue of statistical power in comparative evaluations of minimal and intensive controlled drinking interventions.

An analysis of recent studies of minimal and intensive cognitive-behavioural treatments for problem drinking was undertaken to decide to whether a lack of statistical power explains the failure of the majority of studies to find a difference in outcome between these two types of treatment. Although the sample sizes have typically been small (n = 12-21), the analysis suggests that low statistical power is unlikely to be the explanation for the majority of null findings. It seems more likely that the difference in outcome between one positive study and the majority of null results reflects some combination of differences in the type of clients who were treated, the therapists' experience, and the type of intensive therapy that was provided. The low power of these studies demonstrates the desirability of researchers calculating the sample size required to an effect before commencing an outcome study. If they continue to undertake studies with small sample sizes, then they should refrain from inferring that the failure to reject a null hypothesis means that there is no difference between treatments.

Alcohol Drinking↗
PubMed1991

The reliability and validity of a scale to measure HIV risk-taking behaviour among intravenous drug users.

The initiation and maintenance of substantial behaviour change is required to reduce the spread of HIV infection among the intravenous drug-using population. In order to ascertain the efficacy of interventions aimed at reducing HIV-related risk-taking behaviour among this population, valid and reliable (yet preferably short) instruments for measuring such behaviour are required. The HIV risk-taking behaviour scale (HRBS) is a brief 11-item interviewer-administered scale which examines the behaviour of intravenous drug users in relation to both injecting and sexual behaviour. This paper describes the construction of the scale, in addition to data evaluating its reliability and validity. Initial analyses indicate that the scale has satisfactory psychometric properties.

Adolescent↗
PubMed1991

Estimating drug consumption in opioid users: reliability and validity of a 'recent use' episodes method.

The efficient and accurate measurement of recent drug use is an essential component of treatment and research among opioid users. Urinalysis results alone will not give sufficient information to either the clinician or researcher, due to limitations in detection and an inability to distinguish extent of use. The present paper describes a 'recent use episodes method', adapted from the measurement of alcohol consumption, for obtaining self-reported drug use in eleven different drug categories. Reliability and validity data indicate that the method provides a quick means by which accurate information may be obtained on the overall recent drug use of opioid users.

Adult↗
PubMed1991

Calculating standard drink units: international comparisons.

Simple calculation rules are providing for converting alcohol consumption data among four standard units currently used by researchers and educators in the USA, Canada, the UK, and Australia. A plea is made for the adoption of a common method for reporting alcohol consumption in research, using metric fluid volume units.

Alcoholic Beverages↗
PubMed1991

The experience of fathers in dual-earner families following the births of their first infants.

This study explores the experience of fathers in dual-earner families following the births of their first infants. The grounded theory method was used to collect, code, compare and contrast data gathered in interviews with 10 men. The fathers indicated that they viewed their return to a dual-earner lifestyle as a process of redefining roles. Redefining roles was influenced by four basic life resources and two sets of value systems and occurred in the context of needs which were either met or unmet. The basic life resources and value systems not only influenced family members' needs, but also the two basic strategies which the men used in redefining their roles. First, the men monitored role strain and, second, they limited role strain. Each of these strategies evolved from the central concept of redefining roles. The consequences of redefining roles included effects on marital intactness, family members' health and family members' satisfaction. Redefining roles has implications for nurses who work with men in dual-earner families. As first-time fathers assume multiple roles and struggle with redefining their roles, nurses can offer anticipative and concurrent guidance.

Adult↗
PubMed1991

Public attitudes towards alcohol control policies.

In August 1989 we surveyed a household sample of 500 adults from 84 randomly selected census collector districts in metropolitan and rural New South Wales about their support for 'alcohol control policies' that aim to reduce the prevalence of alcohol-related problems by lowering population alcohol consumption. There was very little support for policies which increased the price or reduced the availability of alcohol. There was moderate support for controls on alcohol advertising, and substantial opposition to policies that would reduce the price of alcohol or increase its availability. Approval for alcohol control policies was more likely to be expressed by women and by persons whose self-reported alcohol consumption was low. If these findings from New South Wales are representative of Australian attitudes then proponents of alcohol control policies face a major task in persuading the public to support them.

Adult↗
PubMed1991

Alpha 1 antitrypsin phenotypes and alcoholic pancreatitis.

Altered frequencies of alpha 1 antitrypsin phenotypes have been reported in patients with chronic pancreatitis, suggesting a possible genetic basis for individual susceptibility to this disease. Alpha 1 antitrypsin phenotypes, with particular regard to alcoholic pancreatitis, were studied. Patients with alcoholic pancreatitis were compared with alcoholic control subjects with no history of pancreatic disease. Serum alpha 1 antitrypsin concentrations were raised in pancreatitis patients sampled within one month of an acute attack of pancreatitis, but otherwise values were similar to those of control subjects. There were no significant differences in alpha 1 antitrypsin phenotypes between alcoholics with pancreatitis and alcoholic control subjects. This study of alpha 1 antitrypsin phenotypes provides no evidence of an inherited susceptibility to alcoholic pancreatitis.

Acute Disease↗
PubMed1991

Sensitivity of the standardized pseudorabies virus neutralization test varies with the test strain used.

The effect of altering the strain of the test virus used in the standardized pseudorabies virus neutralization (VN) test on the sensitivity of the assay was evaluated. Comparative VN tests were performed using 4 different strains: the avirulent Bartha parental, the avirulent recombinant Bartha gIIIKa, the moderately virulent Shope (currently used for the VN test at the National Veterinary Services Laboratory, Ames, IA), and the highly virulent P2208 (Funkhauser). A radioimmunoassay and a Western immunoblotting technique were employed to verify the presence of anti-pseudorabies virus (PrV) antibodies in sera. Statistical analysis indicated that replacement of the Shope strain by the Bartha gIIIKa or the P2208 strain resulted in VN titers that were 4.23- and 2.00-fold higher, respectively. Despite these differences, specificity with regard to PrV diagnosis was unaltered. This apparent enhancement of the sensitivity of the PrV VN test would be beneficial for the serologic identification of PrV-infected animals during an eradication effort.

Animals↗