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Biomedical subjects

W Hager

Publications and source records attributed to W Hager.

At least 55 records · Page 3Linked to original sources
PubMed1977

[Treatment of the experimental chronic digitalisintoxication by hemoperfusion (author's transl)].

In 5 adult dogs experimental chronic digitalis intoxication was produced by oral administration of different digitalis-types (digoxin, beta-methyl-, beta-acetyl-digoxin, digitoxin). 18 to 24 hours after the last application of digitalis, charcoal hemoperfusion was performed in Dipidolor-N2O-anesthesia and serum digitalis-concentrations in the arterial and venous lines of the hemoperfusion system were determined by RIA J125. The Ecg was registered continuously as a simple clinical parameter of cardiac digitalis intoxication. Initial multiple cardiac arrhythmias (AVII degree, SAII degree, tachycardia of the atrium) subsided in the dogs with digoxin, beta-methyl- and beta-acetyl-digoxin during hemocolperfusion within 130 to 160 min. The disturbances of rhythm persisted up to 200 min after onset of hemoperfusion in the dog intoxicated by digitoxin. The clearances of digoxin and derivatives (35.8--43.1 ml/min) are higher than the digitoxin clearance (17--23.2 ml/min) which is supposed to be the reason for cardiac detoxication in the digoxin-intoxicated dogs. Hemoperfusion using polymer coated charcoal appears to be effective for the elimination of digoxin leading to a marked improvement of cardiac arrhythmias. By contrast digitoxin induced cardiac arrhythmias are not influenced during hemoperfusion.

Animals↗
PubMed1977

[Intravascular hemolysis following prosthetic heart valve replacement: influence of type and position of artificial valves (author's transl)].

The present study reports a comparison of the incidence and degree of intravascular hemolysis between patients with disc prosthesis (Björk-Shiley tilting or Lillehei-Kaster pivoting) and patients with Starr-Edwards ball valves (types 1260, 6120) in mitral and aortic position, examined 7 to 30 days and 2,5 to 71 months postoperatively. Malfunction or paraprosthetic valve regurgitation could be excluded. Estimation of serum haptoglobin and serum lactate dehydrogenase activity as the most sensitive parameters indicated clinically inapparent hemolysis in all 4 groups, especially in patients with Starr-Edwards ball valves in aortic position (type 1260).

Adult↗
PubMed1976

[Sinus tachycardia after implantation of a pacemaker for 2 : 1 A-V block with bradycardia (author's transl)].

A demand pacemaker was implanted into a 74-year-old listless woman who was in congestive heart failure, obese and had diabetes mellitus. The ECG indicated a 2 : 1 A-V block (ventricular rate 40/min). Two days after implantation a sinus tachycardia of 98/min occurred and the diabetic metabolic state deteriorated. This was probably due to hyperthyroidism in a thyroid gland of normal size but varying uptake, and was possibly precipitated by the administration of iodine contained in an anti-asthmatic medication.

Aged↗
PubMed1976

[Atypical vagal Wenckebach period in a high performance athlete].

A 27-year-old man, engaged in heavy physical training, exhibited sinusbradyarrhythmia with atrial abnormality and second degree av-block (atypical Wenckebach period). Since abnormal sinusrhythms was established with exercise and following parasympathetic blockade, this rhythm disorder was considered consequential exaggerated vagal tone. With the aid of His-bundle electrocardiography the block was localized in the av-node (AH).

Adult↗
PubMed1975

[Ruptured aneurysm of the aortic sinus of Valsalva (author's transl)].

Three cases of ruptured aneurysm of the aortic sinus of Valsalva (one each into the right atrium, right ventricle and pulmonary artery) are reported and clinical as well as haemodynamic features described. It is pointed out that the right sinus is most frequently involved, the non-coronary one only rarely, and the left one only quite exceptionally. The clinical findings depend on the size, site and direction of the rupture and its haemodynamic consequences. Rupture occurs most frequently into the right attrium or ventricle, much more rarely into the pulmonary artery or left ventricle. Cardinal clinical signs are retrosternal pain, marked shock with dyspnoea and tachycardia or rapidly progressive cardiac failure. Auscultation reveals either a continuous systolic-diastolic murmur or a holosystolic crescendo-decrescendo murmur followed by a high-frequency diastolic murmur, maximal parasternally in the second to fourth left intercostal spaces. As effective surgical treatment is available, early diagnosis is essential.

Adult↗
PubMed1975

[1-Year-results of anuloplastisy (Carpentier-technic) in 7 patients (author's transl)].

Of 7 patients who had Carpentier anuloplasty, two had very good, two had good and two had unsatisfactory results in postoperative cardiac catheterization one year after operation. One patient died of acute hepatitis. Reasons for the poor results are false indications and inadequate operative technic. These results show that the Carpentier-technic can well be recommended for critical use in carefully selected patients with mitral insufficiency.

Adolescent↗