Failure of the unopened colostomy to protect high-risk rectal anastomoses.
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Biomedical subjects
Publications and source records attributed to W H Thomson.
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This paper reviews the published data relating to the radiation hazards associated with nuclear medicine outpatients. It is discussed both in the context of the current UK advice as well as potential guidelines following the recommendations in ICRP 60. For diagnostic studies there is little need for restrictions. The main exceptions are for a prolonged journey home by public transport with high levels of 99Tcm and for the situation of an outpatient given 111In who has to look after a fretful infant. The main problem occurs following the administration of 131I therapy for thyrotoxicosis. The principal hazards are associated with external exposure; radiation doses from ingestion due to contamination are small. Restrictions should only be necessary for administered activities greater than 400 MBq (e.g. public transport, return to work, sleeping with partner). With such restrictions it is considered that 131I therapy for thyrotoxicosis can continue to be given on an outpatient basis.
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A patient satisfaction survey was carried out in a nuclear medicine department of a large acute hospital. Surveys were initially carried out by interview and postal techniques, with approximately 100 responders in each category. The responses to each question were not significantly different for the two types of survey, although overall there was a significantly larger number of dissatisfied responses in the postal survey (22%) compared with the interview study (12%). The postal survey was repeated after 1 year, thus completing the audit loop. A significant reduction in dissatisfied responses has occurred in those areas which had been addressed following the criticisms revealed by the first survey.
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We have examined the implications of ICRP60 for nuclear medicine. Radiation doses to staff are currently low and reduction of the dose limits will have little impact. However, the proposed figures for the fetus may have implications for pregnant women where the workloads are high. With nursing staff on the ward, laboratory staff or indeed departmental porters there seems little problem. Radiation dose to the fingers is, however, a key factor, and ensuring that no further restrictions are placed on the proposed dose limits is important. The concept of constraints is becoming clearer but will need further thought, particularly with regard to exposure of the general public. The previous basis for declaring controlled and supervised areas has been abandoned, and the situation is now less clear. A most important area of debate will be the patient who is a controlled area, and great care will have to be taken to ensure that the number of patients in this category is not increased so that many more patients need to be kept in hospital. Exposure of the general public is also an issue and expanding the concept of medical exposure to include carers is an important development. This should prevent a number of unnecessary restrictions and adds weight to the point that two waiting rooms are not justified in nuclear medicine departments. ICRP recommendations will soon be incorporated into the legislation of member states and it is import for everyone to ensure that drafts are read carefully and that national proposals are not too restrictive.
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The mucosa of the pelvic ileal reservoir undergoes adaptive changes--inflammatory, architectural, and metaplastic--on exposure to the faecal stream. Twenty three quadruple loop ileal pouches constructed for ulcerative colitis (20 patients) and familial adenomatous polyposis (FAP) (three patients) were studied. No patient fulfilled clinical, endoscopic, or histopathological criteria for pouchitis. Standard duplicate biopsy specimens were taken from the proximal limb, the anterior wall, the posterior wall, and the body of the reservoir. An established scoring system was used and showed a highly significant increase in inflammatory scores in posterior wall biopsy specimens compared with those from the anterior wall. These results suggest that the adaptive changes are the direct result of contact with static faecal contents. One patient only showed significant inflammation in the proximal limb. There was no evidence of mucosal prolapse in any anterior wall biopsy specimen. Patients with colitis showed substantially more inflammatory and architectural changes than those with FAP. Ninety six per cent of pouches showed some colonic phenotypic expression as defined by mucin histochemical and PR 3A5 immunohistochemical studies. Our results suggest, however, that there may not be complete colonic metaplasia and that the mucin changes and other phenotypic alterations may represent a non-specific response to pouch inflammation and not a prerequisite for the development of pouchitis. The focal nature of the inflammatory and architectural changes, which may be the result of direct contact with static faecal residue, are clearly shown. A single random biopsy specimen of pouch mucosa is of limited value in assessing pathological changes and screening for potential neoplastic change within the reservoir.
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The ICRP has now recommended that the dose limit to the surface of the mother's abdomen during the declared term of pregnancy is reduced to 2 mSv. Direct measurements of the radiation dose to technologists carrying out a variety of imaging studies were made. The average dose ranged from 0.3 micro Sv for a liver scan to 5.3 micro Sv for a brain scan. Using national data for the frequency of nuclear medicine studies, a weighted average figure of 1.5 micro Sv per study was derived. A technologist could therefore perform approximately eight imaging studies per day during the declared term of her pregnancy and remain within the proposed limit. Generally, there should be no need to alter a technologist's duties during her pregnancy, and these findings should be helpful in allaying any anxiety.
The outcome in 72 patients with obscure abdominal pain and a positive Carnett's (abdominal wall tenderness) test, seen in one firm's surgical outpatient clinic between 1975 and 1983, was sought by a combination of hospital note retrieval and general practitioner questionnaire. Full follow-up data to date or death were available for 58 (81 per cent) patients and partial follow-up for 14 patients. The study showed that the patients generated a good deal of investigation and a number of surgical procedures but that seldom were their symptoms attributable to serious pathology. Familiarity with the test, taken in the context of a proper history and examination, has been found helpful in assessing such patients and saves the inconvenience, expense and occasional hazard of investigation, and even surgery.
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The usefulness of the rebound tenderness test in indicating peritonitis was prospectively assessed in 142 unselected patients admitted as emergencies with abdominal pain and tenderness. It was found to be of no predictive value.