Biomedical subjects
W H Hunter
Publications and source records attributed to W H Hunter.
Neodymium: YAG transscleral cyclocoagulation in human eyes.
Transscleral neodymium: YAG (Nd:YAG) cyclocoagulation has been successfully used to lower intraocular pressure (IOP) in rabbits. The authors treated 24 patients with uncontrolled glaucoma using the thermal mode of the Nd:YAG laser. The patients were followed for a mean of 8.8 months. A total of 62.5% of treated eyes achieved an IOP on last follow-up of 25 mmHg or less. The mean pretreatment pressure was 47.2 mmHg and the mean posttreatment pressure was 25.7 mmHg (P = 0.009). The complications and potential clinical usefulness of this mode of therapy are discussed.
A thermodynamic analysis of the Collander equation and establishment of a reference solvent for use in drug partitioning studies.
A thermodynamic analysis of the Collander equation, ln PI = a + b ln PII (I and II refer to two different partitioning systems with partition coefficients PI and PII, respectively), is given and applied to three forms of correlation. The intercept, a, is shown to have no general fundamental significance whereas the slope, b is shown to reflect differences in non-aqueous solvent properties; b is also shown to be of use in scaling solvent behaviour to select solvents which closely represent biological membrane properties for use in partitioning studies. Laboratory and literature data are subjected to the analysis.
Neodymium-YAG transscleral cyclocoagulation in rabbit eyes.
Transscleral ruby cyclocoagulation has been successfully used to lower intraocular pressure. The recent commercial availability of Nd-YAG lasers with a thermal mode provides a possible alternative by which to perform this procedure. We treated one eye of seven pigmented rabbits using the thermal mode of the Nd-YAG laser. The intraocular pressures were followed up for three months. The treated eyes had significantly lower mean intraocular pressures were followed up for three months. The treated eyes had significantly lower mean intraocular pressures than the untreated contralateral eyes (p less than 0.001). Moreover, the decrease was sustained over the three-month duration of the study. Pathological examination revealed very selective destruction of the ciliary processes, with sparing of the overlying ciliary muscle, sclera, and conjunctiva. The potential value of this mode of therapy for use in patients with glaucoma is discussed.
Lawrence Garvin Clayton, M.D.
Explore the source record for details and available documents.
The synthesis of some bridgehead N,O-heterocycles of biological interest.
The preparation of 5-aryl-6-oxa-1-azabicyclo[3,3,0]octanes, 6-aryl-5-oxa-1-azabicyclo[4,3,0]nonanes and 7-aryl-6-oxa-1-azabicyclo[5,3,0]decanes from the corresponding substituted omega-chlorobutyrophenones and aminoalcohols is described; and the ring opening reactions are studied. A preliminary biologic activity study has also been conducted, and demonstrated that the 5-(2,5-dimethyl)phenyl-6-oxa-1-azabicyclo[3,3,0]octane possesses antiinflammatory activity.
Medicine's "future shock".
Explore the source record for details and available documents.
The metabolism of acetamidothiazoles in the rat. 2-Acetamido-, 2-acetamido-4-methyl- and 2-acetamido-4-phenyl-thiazole.
The metabolism of some anti-inflammatory acetamidothiazoles was studied in the rat. The main metabolites were the corresponding acetylthiohydantoic acids, produced by fission of the thiazole ring. Minor metabolites arising from oxidation of the methyl or phenyl substituents were also identified. The structures of metabolites were established spectroscopically (u.v., i.r., n.m.r. and mass spectroscopy) and by identification with authentic specimens. The excretion of the original compounds and of metabolites, labelled with (14)C is also reported.
The metabolism of acetamidothiazoles in the rat. 2-acetamido-4-chloromethylthiazole.
2-Acetamido-4-chloromethylthiazole is metabolized in the rat to (2-acetamido-4-thiazolylmethyl)mercapturic acid and 2-acetamidothiazole-4-carboxylic acid. 2-Acetamido-4-methylthiomethylthiazole and the corresponding sulphoxide and sulphone are also produced as minor metabolites. The identification of the metabolites is described and their formation investigated. Quantitative results on the excretion of the metabolites labelled with (14)C are reported.
A safety device for use with the Unicam SP 90 atomic absorption spectrophotometer.
Explore the source record for details and available documents.
The metabolism of thioamides by the supernatant fraction of rat liver homogenate.
Explore the source record for details and available documents.
The preparation and pharmacological properties of psi-corbasil.
Explore the source record for details and available documents.
Some problems in Q fever infections in New South Wales.
Explore the source record for details and available documents.
The metabolism of some 4-acetyl-1-naphthyl ethers in the rat and their effect upon liver microsomal oxidation.
Explore the source record for details and available documents.
The hydrolysis of acetylsalicylic acid by liver microsomes.
Explore the source record for details and available documents.
Synthesis and pharmacological action of some N-alkyl morpholines and their salts.
Explore the source record for details and available documents.