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Biomedical subjects

W H Friedman

Publications and source records attributed to W H Friedman.

82 records · Page 5Linked to original sources
PubMedDate not supplied

Benign cystic vs. solid lesions of the parotid gland in HIV patients.

In this study of 13 patients with cystic lesions of the parotid gland, 9 patients were known to be antibody positive for the human immunodeficiency virus (HIV) and 4 were subsequently tested to be positive. All patients had computed tomographic (CT) confirmation of parotid gland cysts. Five patients had fluid aspirates showing high amylase levels. All cystic lesions had lymphoepithelial features and lymphoid histology similar to those seen in HIV infection. This study includes a review of 148 HIV patients reported in the literature, as well as our experience. Of all the reported cases, when gross pathology suggested cystic lesions, the incidence of malignancy was close to 1%. The incidence of malignancy for a solid mass, however, was close to 40%. We propose a nonsurgical management protocol which includes CT scan and needle aspiration with tissue for cytology and fluid for amylase level if possible. Watchful observation is advised for cystic pathology.

AIDS-Related Complex↗
PubMedDate not supplied

Computed tomography of the normal larynx.

A computed tomographic analysis of normal laryngeal anatomy was undertaken using cadaver larynxes. This was part of a larger project in which patients with laryngeal carcinoma were routinely evaluated in the computed tomographic (CT) body scanner. The appearance of normal laryngeal anatomy had to be delineated before disease processes of the larynx were evaluated, and this was accomplished using a computed tomographic technique with 5-mm slice thicknesses and a 3-mm overlap. The scan slices were then compared with anatomic sections taken at the same levels. The comparisons demonstrate an ideal level of accuracy that can be approached in the in-vivo larynx only with use of the latest-generation scanners. However, CT scanning is of immediate usefulness in the diagnosis of laryngeal pathology.

Humans↗
PubMedDate not supplied

Computed tomography vs laryngography: a comparison of relative diagnostic value.

The computed tomography (CT) scans and laryngograms of 25 patients with laryngeal cancer were compared and evaluated in an assessment of the diagnostic accuracy of each modality in the supraglottic, glottic, and subglottic regions. Fourth generation scanners were used in these patients, all of whom subsequently underwent laryngectomy or partial laryngectomy. The clinical superiority of CT scanning was evident in several areas--confirming clinical impressions that laryngography is not as accurate as CT, is frequently misleading, and offers no significant advantages over CT. In this regard, we now believe that computed tomography is the most important radiologic adjunct in the diagnosis of laryngeal cancer, and we no longer order the laryngogram on a routine basis.

Arytenoid Cartilage↗
PubMedDate not supplied

Osteoid-producing orbital ethmoid tumor.

Fibro-osseus lesions of the paranasal sinuses, especially those that contain multinucleated giant cells, demonstrate a significant histopathologic overlap although they manifest themselves throughout a wide range of clinical behavior. They routinely require a critical clinical and pathologic interpretation. Often, the clinical course of the disease is the only guide to diagnosis and mode of treatment. This study presents the case of a 4-year-old boy with an osteoid-producing tumor of the ethmoid sinus. Despite an original diagnosis of fibrous dysplasia, the lesion followed a relentless course. Eventually, maxillectomy, orbital exenteration, and craniotomy were required to control the disease. The literature of fibro-osseous lesions of the paranasal sinuses is reviewed and an attempt is made to classify these lesions according to their clinical behavior.

Child, Preschool↗
PubMedDate not supplied

Sphenoethmoidectomy: its role in the asthmatic patient.

Fifty patients who underwent intranasal sphenoethmoidectomy at the St Louis University Medical Center between July 1977 and April 1980 have been evaluated with respect to preoperative extent of disease and medication requirement as well as postoperative course and reduction in medication requirements, if any. These patients were followed jointly by the Departments of Allergy and Otolaryngology. Most of these patients were not allergic, and over half had intrinsic asthma. Fifteen of the 50 patients, all asthmatic, gave a history of aspirin sensitivity. Many had had previous nasal surgical treatment for polyps. Patients on large corticosteroid dosages had long-lasting reductions or elimination of their corticosteroid requirements in most cases. Similarly, most patients had long-lasting nasal airway improvement and reduction or elimination of recurring sinusitis. Antibiotics and antihistamine-decongestant preparations were sharply diminished in these patients. Although aspirin sensitivity was associated with some of the more severe asthmatic patients, it appeared not to be a factor in the responses to surgical treatment.

Adrenal Cortex Hormones↗
PubMedDate not supplied

Quadrangular rhytidoplasty.

A four-angled incision for the performance of rhytidoplasty has been utilized for the past 2-1/2 years. This approach has provided excellent results and is suggested as a flexible, cosmetic incision providing easy access to the temporal, malar, mandibular, and cervical integument.

Dermatologic Surgical Procedures↗