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Biomedical subjects

W H Carter

Publications and source records attributed to W H Carter.

At least 91 records · Page 5Linked to original sources
PubMed1979

An improved method for analyzing survival data from combination chemotherapy experiments.

In this paper, we present a new method for analyzing survival data from combination chemotherapy experiments. The analysis consists of relating survival to the dosage level of each drug in the combination and using response surface techniques to determine the importance of drug interactions and to estimate optimal doses. A combination experiment using cyclophosphamide, mechlorethamine, and mitomycin C in early L1210 leukemia, advanced L1210 leukemia, and advanced P388 leukemia is used to illustrate the analyses. A therapeutic synergism has been shown. As a result of the various drug interactions, the predicted optimal dose of mitomycin C is found to be zero. This result was duplicated in each tumor system studied.

Animals↗
PubMed1978

The determination of antibody to Streptococcus mutans serotypes in saliva for children ages 3 to 7 years.

The saliva of 29 children ages 3 to 7 years was followed by indirect immunoflourescence to determine the antibody reacting with the 5 different serotypes of S mutans. Fluorescent antisera specific for alpha chain and gamma chain were used. Statistical analysis of the data demonstrated a significant negative correlation between antibody of immunoglobin class (IgA) to S mutans type b and the decayed, extracted and filled surfaces of deciduous teeth.

Antibodies, Bacterial↗
PubMed1978

Combination chemotherapy: arriving at optimal treatment levels by incorporating side effect constraints.

This paper represents a method for determining optimal dose levels in a drug combination by analyzing the dose-response surfaces estimated from experimental data. In addition to using the presence or absence of a favorable response (in this instance, survival for at least twice the median untreated lifespan of B6D2F1 female mice bearing advanced sc implanted L1210 leukemia), the presence or absence of associated side effects is also employed (in this instance, Day-12 weight loss). The technique is potentially superior to existing methods of responding to the occurrence of treatment side effects due to its ability to take into account interactions between drugs. Since this method offers a way to determine optimal dose by including nonlethal toxicity information; it should find application in clinical situations.

Animals↗
PubMed1977

On determining the levels of treatment to optimize the probability of a favorable response.

This paper presents a statistical method for analyzing the dose response surface associated with treatments resulting from combinations of any number of cytotoxic agents. The results of such an analysis are the dosages of each agent in the combination which will maximize the probability of a favorable response. An example utilizing a combination of hexamethylmelamine and ICRF-159 is presented. The predictive ability of the model is verified by a kappa 2 goodness of fit test. The advantages of such a method relate to its potential applicability to more complex experimental situations where multiple drugs are used in combination and/or where variations in timing of drug administration exist.

Altretamine↗