Extraction of aflatoxin from rat liver.
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Aflatoxins↗
Biomedical subjects
W H Butler
Publications and source records attributed to W H Butler.
A review of the hepatic tumors related to mixed-function oxidase induction in the mouse.
Mixed-function oxidase (MFO) induction in the mouse liver results in a rapid and sustained centrilobular hypertrophy associated with a hyperplastic response. In many studies, the long-term sequela of prolonged exposure is an increased incidence of lesions considered to be adenomas. Studies have shown in aged control mice that the burden of adenomas usually consists of lesions with basophilic cytoplasic staining and a uniform population of hepatocyte nuclei. With long-term feeding of MFO inducers, there is an additional burden of lesions diagnosed as adenomas having a different histological appearance with increased eosinophilic cytoplasm and pleomorphic nuclei. The incidence of hepatocarcinomas usually is not modified by the increased incidence of eosinophilic adenomas. Studies into the behavior of the eosinophilic lesions show that the hepatocytes approximate in their behavior to normal and not neoplastic cells. It is suggested that these lesions should not be considered a carcinogenic response to the chemical.
Animals↗
Mesenchymal tumors of the mouse urinary bladder with vascular and smooth muscle differentiation.
Bifenthrin, a synthetic pyrethroid insecticide/miticide, has been fed to male and female Swiss Webster mice at levels of 0, 50, 200, 500, and 600 ppm in the diet for between 604 and 644 days. Tumors of the urinary bladder were observed and initially reported as leiomyosarcomas. Subsequently, the bladders were reviewed and the tumors showed a pattern of both epithelioid cells and spindle cells forming irregular vascular channels. The tumors appeared to arise from the trigone of the bladder and, in some cases, invaded the bladder wall. No metastases were recorded. The tumor is usually considered rare; however, in this study, it was commonly observed in all groups but predominantly in males. The histogenesis of the tumor is uncertain, but from its pleomorphic histological features, including smooth muscle and vascularity, it is probably derived from vascular mesenchyme.
Animals↗