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Biomedical subjects

W Greenfield

Publications and source records attributed to W Greenfield.

At least 19 recordsLinked to original sources
PubMed1999

BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator.

The tumor necrosis factor (TNF) superfamily of cytokines includes both soluble and membrane-bound proteins that regulate immune responses. A member of the human TNF family, BLyS (B lymphocyte stimulator), was identified that induced B cell proliferation and immunoglobulin secretion. BLyS expression on human monocytes could be up-regulated by interferon-gamma. Soluble BLyS functioned as a potent B cell growth factor in costimulation assays. Administration of soluble recombinant BLyS to mice disrupted splenic B and T cell zones and resulted in elevated serum immunoglobulin concentrations. The B cell tropism of BLyS is consistent with its receptor expression on B-lineage cells. The biological profile of BLyS suggests it is involved in monocyte-driven B cell activation.

Amino Acid Sequence↗
PubMed1993

Rapid cocaine screening of urine in a newborn nursery.

A rapid cocaine screening test, the Abuscreen OnTrak assay, was compared with the EMIT (enzyme-multiplied immunoassay technique) screening test to determine relative accuracy in 450 newborn infants sequentially tested for urinary cocaine during a 6-week period at a large urban hospital. The Abuscreen Ontrak screen had a sensitivity of 96% and a specificity of 100%.

Cocaine↗
PubMed1987

The physically disabled dentist: 10 years' experience at the Kriser Institute.

This article outlines the origins, development, and current status of the David B. Kriser Institute for the Rehabilitation of Disabled Dentists. During its first decade of existence this unique facility has provided retraining for more than 30 physically disabled dentists who have subsequently been able to resume dental practice. A case study highlights the Institute's mode of operation.

Adult↗
PubMed1980

Occupational disease in dentistry and chronic exposure to trace anesthetic gases.

A mail survey of 30,650 dentists and 30,547 chairside assistants grouped according to occupational exposure to inhalation anesthetic and sedatives in the dental operatory indicated increased general health problems and reproductive difficulties among respondents exposed to anesthetics. For male dentists who were heavily exposed to anesthetics, the increase in liver disease was 1.7-fold, kidney disease was 1.2-fold, and neurological disease was 1.9-fold. For wives of male dentists who were heavily exposed to anesthetics, the increase in spontaneous abortion rate was 1.5-fold. Among female chairside assistants who were heavily exposed to anesthetics, the increase in liver disease was 1.6-fold, kidney disease was 1.7-fold, and neurological disease was 2.8-fold. The increase in spontaneous abortion rate among assistants who were heavily exposed was 2.3-fold. Cancer rates in women heavily exposed to inhalation anesthetics were increased 1.5-fold but this finding was not statistically significant (P = .06). Separate analysis of the data for disease rates and birth difficulties by type of inhalation anesthetic indicates that in both dentists and chairside assistants chronic exposure to nitrous oxide alone is associated with an increase rate of adverse response.

Abnormalities, Drug-Induced↗
PubMed1977

Trace contamination of anesthetic gases: a brief review.

Data have been reviewed relevant to the effects of chronic exposure to trace quantities of inhalation anesthetic agents. Much circumstantial evidence exists indicating a probable hazard to the clinician administering these agents. However, all previous studies in man have not identified the potential hazard of nitrous oxide without the presence of other contaminating agents.

Abortion, Spontaneous↗
PubMed1975

Citanest Forte--its use in oral surgery.

A clinical evaluation of Citanest Forte (brand of prilocaine HCL) was carried out on 3,000 oral surgery patients to determine the effectiveness and safety of the drug. Citanest Forte has been found to be a useful local anesthetic, and the results of this study would indicate that it can be effectively and safely substituted for other local anesthetic solutions currently in use for all routine oral surgery procedures.

Adult↗