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Biomedical subjects

W Green

Publications and source records attributed to W Green.

78 records · Page 5Linked to original sources
PubMedDate not supplied

Testicular plasmacytoma in a patient with the acquired immunodeficiency syndrome.

Clinical, laboratory, and pathologic findings from a case of primary extramedullary plasmacytoma of the testis and sinuses in a patient with acquired immunodeficiency syndrome (AIDS) are presented. To our knowledge this is the first case in the English literature of a primary testicular plasmacytoma in an HIV-infected patient. The findings in this report and those of others confirm the difference in the pattern of plasma cell tumor (PCT) presentation in patients infected with AIDS from those in non-infected individuals, suggesting that these tumors should be considered in the differential diagnosis of AIDS-associated malignancies.

Acquired Immunodeficiency Syndrome↗
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Musical medicine.

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Hospital-Patient Relations↗
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The Philadelphia story.

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Education, Continuing↗
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Persistent sodium currents induced by anthopleurin-A and their relationship to early afterdepolarizations in ventricular myocytes.

Prolonged Na+ current inactivation was induced in neonatal rat ventricular myocytes by exposure to Anthopleurin-A (80-240 nM). In control whole-cell voltage clamp recordings, prolonged Na+ current inactivated mono-exponentially from peak with time constant, tau h, averaging 1.5 msec +/- 0.2 msec at -30 mV and peak current averaging 0.7 +/- 0.3 nA (n = 10). Steady state inactivation was complete at -50 mV and there was little or no overlap of prolonged Na+ current inactivation and activation processes. One to 3 minutes following exposure to Anthopleurin-A, the rate of inactivation slowed, with tau h increasing to 21 +/- 5 msec at -30 mV, and peak prolonged Na+ current increasing to 1.3 +/- 0.5 nA (n = 10). Steady state inactivation was shifted in a positive direction, and complete inactivation did not occur even at +10 mV. Persistent inward currents were thus induced by Anthopleurin-A. They were most prominent at depolarizations slightly above threshold for activation and were selectively blocked by lidocaine (60 microM). Action potentials were prolonged by Anthopleurin-A, especially at slow stimulation rates, and were accompanied by early afterdepolarizations. The correlation between persistent inward currents and early afterdepolarizations, in terms of voltage dependence, appearance and pharmacology, suggests a possible causal role for persistent Na+ currents in this model of early afterdepolarizations.

Action Potentials↗