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Biomedical subjects

W Golder

Publications and source records attributed to W Golder.

At least 55 records · Page 3Linked to original sources
PubMed1998

[The impact factor: a critical analysis].

The impact factor, provided by the Institute for Scientific Information, Philadelphia (PA), has become the most important evaluation tool for scientific research and academic work. It is calculated by dividing the number of current year citations to the source items published in the journal during the previous two years. In market research, the impact factor provides quantitative evidence for editors and publishers for positioning their journals in relation to the competition. Despite its popularity, the parameter should be used with careful attention to the many phenomena that influence citation rates. The correlation between the citation frequency of a certain article and the impact factor of the journal in which it is published is questionable. A few articles have many citations and the rest are sparsely cited or not at all. Citation impact is more a measure of utility than of scientific value. Authors' selection of references is subject to biases unrelated to quality. Moreover, there is a tremendous bias towards English language journals compared with those in other languages. Finally, different specialties exhibit different ranges of peak impact. The impact factor favours research areas that promote many short-term studies. Conversely, a tendency to treat clinical investigations as less important is created.

Bibliometrics↗
PubMed1998

[Radiation-induced osteonecrosis of the pelvic bones vs. bone metastases--a difficult differential diagnosis].

BACKGROUND: Since the introduction of megavoltage radiation therapy radiation osteitis has become a rare event and may be easily mistaken for bone metastases. A case of radiation osteitis is reported and diagnostic features are discussed. CASE REPORT: A 70 year-old female patient underwent rectum resection for rectum cancer and was given standard adjuvant therapy consisting of irradiation of the tumor site and lymph nodes in the pelvis with 18 MeV photons, boxfield technique up to 50.4 Gy and chemotherapy with 5-FU. Eight months later she complained of severe lower back pain. Plain radiographs and CT revealed osteolytic lesions in the ileosacral joints and os sacrum which appeared as circumscript areas of signal loss in MRI (T1-weighted sequence). A soft tissue mass was not detected. CT-guided biopsy excluded bone metastases. CONCLUSION: Characteristic features of radiation osteitis are spongiosa destructions initially in weight-bearing bones within the radiation field, namely the ileosacral joints, and the lack of pathologic soft tissue mass. False treatment, i.e. radiation for bone metastases, should be avoidable.

Aged↗
PubMed1997

[Autoantibodies against centrosomes in a patient with limited systemic sclerosis with ulcera cruris and arteriopathy--case report and review of the literature].

A 63 year old woman developed painful, up to 15 x 7 cm large ulcers on both lower limbs and an acral necrosis on the right big toe. The patient had no symptoms of intermittent claudication, but a history of 40 package years of cigarette smoking. Angiography showed circumscript stenosis of medium-sized vessels, deformed vessel segments, and rarification and obstruction of peripheral vessels. Arterial occlusive disease was diagnosed, and percutaneous transluminal angioplasty (PTA) of the right common iliac artery and both femoral arteries performed. However, despite documented patency of these vessels clinical symptoms worsened. The consulting rheumatologist found a history of Raynaud's syndrome, acral necrosis of the fourth finger of the right hand, sclerodactylia, and microstomia. Capillaroscopy revealed megacapillaries and vessel rarification. High titers of antinuclear antibodies with specificity for centrosomes (1:10240), which have not been described in this context to date, were detected and limited systemic sclerosis of the CREST type was diagnosed. Treatment with iloprost (50 micrograms/day i.v.) and pulsed cyclophosphamide (800 mg i.v./month) resulted in almost complete healing of the crural and digital ulcers and a significant reduction of the analgetic medication.

Antibodies, Antinuclear↗
PubMed1996

Interventional radiology in the treatment of blunt liver trauma: case report with review of literature.

Hepatic trauma remains one of the most serious problems in abdominal injury. Whenever possible a non-resectional approach is clearly preferred. Refinements of interventional radiology as an adjunct to surgery in blunt liver trauma may play an increasingly vital role in reducing mortality. The literature is reviewed with reference to the diagnostic procedure and the treatment strategy in blunt liver trauma.

Adult↗
PubMed1995

[MRI of the knee joint: first results of a comparison of 0,2-T specialized system and 1,5-T high field strength magnet].

PURPOSE: Diagnostic accuracy and image quality of a specialised system for MR examinations of peripheral joints were evaluated. MATERIALS AND METHODS: 20 patients with acute or chronic injuries of the knee were examined using a low-field MR system (0.2 T). For comparison, all patients were also studied with a 1.5 T high field strength magnet and all diagnoses were correlated with arthroscopic findings. RESULTS: We found compatible diagnostic accuracies (cruciate ligaments 90%, menisci 75-90%) and good image quality ratings for the low field system ("good" and "excellent" image quality in 83% of cases). CONCLUSION: The low-field MR-system offers low-cost MR examinations of peripheral joints with good image quality and reliable diagnostic information.

Adult↗
PubMed1994

[Acute ischemia of an arm as an unusual manifestation of ergotism].

A 27-year-old woman developed acute pain, pallor and feeling of cold in her left arm. She had been a smoker of 15-20 cigarettes daily since the age of 15 years, but had not previously had any serious illness. In addition to contraceptives she had had been taking one to several suppositories containing caffeine and ergotamine tartrate (2 mg) daily against migraine. Angiological examination 5 days after onset of symptoms discovered a weak brachial pulse low in the left upper arm, while ulnar and radial pulses were absent. All other pulses were normally palpable. Colour duplex sonography demonstrated occlusion of the brachial artery which angiographically was due to a 5 cm severe narrowing without thrombus, blood flowing distally via collaterals. No improvement was achieved by local injection of 100,000 IU urokinase, 0.5 mg nitroglycerin, 20 mg tolazoline and a 3-hour infusion of alprostadil. On infusion of 560 ml hydroxyethylstarch over 8 hours, 400 mg naftidrofuryl, therapeutic doses of heparin and abstinence from ergotamine (since admission) the vessel diameter increased by 50% within 23 hours and after a further 24 hours to almost 100% of the comparable arterial segment of the right arm while merely on heparin infusion.

Acute Disease↗