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W Gepts

Publications and source records attributed to W Gepts.

104 records · Page 6Linked to original sources
PubMedDate not supplied

Early morphologic changes in coronary arteries of experimental diabetic rats.

Diabetes was induced in 24 adult male Wistar rats by a single intravenous injection of streptozotocin. The ultramorphology of the coronary arterial wall was studied by scanning and transmission electron microscopy up to 10 weeks following this diabetes induction. At that moment, several ultrastructural characteristics of primary atherogenesis could be observed, i.e. important myointimal thickening with extensive medial smooth muscle cell migration towards and into the intima, and synthesis of an abundant mass of intercellular ground substance in the media and in subendothelial areas. Lipid deposition or foam cell formation was not observed. These results confirm that experimental diabetes is a risk factor for the coronary arterial wall as it induces typical atherogenic phenomena.

Aging↗
PubMedDate not supplied

An immunohistochemical study for testicular biopsies in cases of male infertility.

Immunohistochemical and morphological examination of 50 bilateral testicular biopsies of infertile men shows the presence of immunoglobulin in 20% of the cases, suggesting that testicular immune phenomena might be implicated in the pathogenesis of infertility. Several observations make it clear that immune phenomena are labile and that only a multidisciplinary and dynamic approach can bring some progression in this field.

Adult↗
PubMedDate not supplied

[Morphological aspects of the etiopathogenesis of human diabetes (author's transl)].

From a morphological point of view, two distinct pathological pictures emerge in the common types of human diabtetes. The first is characterized in the initial phase of the disease by inflammatory lesions in the islets of Langerhans. These lead to fibrosis and apparent atrophy of the islets, which in a more advanced stage are composed of non-insulin-producing cells, the B-cells having been largely destroyed. This picture is specific and diagnostic for the classical insulin-dependent type of diabetes, which occurs more often in young individuals. The second is characterized by a variable, but on the average moderate reduction of the number of B-cells, and by degenerative islet changes (fibrosis, hyalinosis). Despite the long lasting hyperglycemia to which they have been submitted, the B-cells fail to develop cytological features of hyperactivity. This pathological picture is associated with the classical insulin-independent, maturity-onset type of diabetes.

Diabetes Mellitus↗