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Biomedical subjects

W Gehlen

Publications and source records attributed to W Gehlen.

53 records · Page 3Linked to original sources
PubMed1977

[Analysis of chronic psychotic states in young drug-addicts (author's transl)].

60 young drug-addicts with prolonged psychotic states have been examined. Taking account of the family situation and psychosocial development, of typical timing and drug-specific factors the psychopathologic picture is described as to its course and the multiple effects of drugs. An existing psychosis may be the motive for drug-taking in special ways. On the other hand there is with many patients a coincidence in time between drug-addiction and manifestation of the psychosis. Psychoses independent from drugs i.e. running their own specific course, are seen remarkably often. They cannot be distinguished phenomenologically from endogenous psychoses and end up quite often in a number of defects.

Adolescent↗
PubMed1976

[Differential diagnosis and syndrome-genetic problems and aspects of drug-induced psychoses in juveniles (author's transl)].

Acute and chronic psychotic states in juvenile drug addicts demand careful observation of syndrome-genetic and differential diagnostic factors. Not only the diagnosis of a schizophrenic or affective juvenile psychosis and their differentiation from phase-specific developmental crises may often be difficult. A further problematic field are special aspects of symptomatic psychoses and particularly states due to drug addiction with hashish, LSD and amphetamines and the effect of drugs on already existing endogenous psychoses. This demands subtile phenomenologic description and syndrome-genetic assessment. One will have to take into account the complexity of drug effects and whether a psychosis existed already before addiction, whether drugs have provoked a latent psychosis, whether a purely symptomatic psychosis mimics a schizophrenia or whether irreversible personality changes with secondary psychotic behavior have developed.

Acute Disease↗
PubMed1975

[Methods for recording and quantitative measurement of rigidity and spasticity (author's transl)].

First pathophysiological aspects of rigidity and spasticity are described with special regard to the possibilities of errors during the measurement of muscle tone in man. The following methods are explained and discussed: Psychometric techniques, physical analysis of movements (kinesiology, photobadismography, kinetometry), pendulousness tests, investigations of reflexes (T-reflex, H-reflex, H/M-ratio), electromyographic methods (after-activity, silent period, unloading-reflex, stretch-reflex, release-phaenomen), and torque measurements. In the main we discussed these techniques with the view-point of diagnosis and drug effects. Furthermore we expressed our opinion on the relevance of the different methods. Last the most important sources of errors are tabulated.

Electromyography↗
PubMed1975

[Schizophrenic defect syndromes and drive behavior].

First the terms "impulse" (Antrieb) and "schizophrenic defect" (schizophrener Defekt) are explained and defined. 49 (= 12 per cent) of the 409 schizophrenic in-patients, treated 1970-1972, had the symptoms of a schizophrenic defect. All of them showed disturbances of impulse: more than half the patients a deficiency, nearly a third an unsettled surplus, and about ten percent an alternating impulse. The deficiency as the alternating impulse usually were accompanied with a negativ mood. The surplus of impulse was bound up as equal parts with positive and negative moods. At last any kind of disturbances of described is illustrated by an example.

Adult↗
PubMedDate not supplied

The cognitive-mnestic performance profile of a patient with bilateral asymmetrical thalamic infarction.

The case of a 46-year old patient with a bilateral medial thalamic infarct, affecting mainly the region of the internal medullary lamina, but not of the mammillothalamic tract, is documented neuropsychologically and neuroradiologically. Testing was done after acute remission. The patient was of average intelligence but manifested a number of verbal memory problems. These are most likely attributable to the selective diencephalic damage and are interpreted as a disconnection syndrome.

Cerebral Infarction↗
PubMedDate not supplied

MR imaging in multiple sclerosis: comparison with clinical, CSF, and visual evoked potential findings.

MR examinations of 136 patients with multiple sclerosis (MS) were evaluated to correlate the results with clinical, CSF, and visual evoked potential (VEP) findings. In addition, 22 of the 136 patients were studied several times during a 5-month follow-up period. It was demonstrated that MR is superior to CSF and VEP findings in establishing cerebral alterations in MS. A relationship between the results of CSF and VEP examinations and the MR results could not be detected. Negative CSF and VEP results corresponded to positive MR imaging and vice versa. In our series, five negative MR results were obtained in patients with clinically proved MS. The extent of alterations shown up by MR corresponds to the duration of the disease; in particular, more confluent abnormalities in the periventricular region were found in patients with long-standing disease. More plaques were found in patients with a primary relapsing/remitting course of the disease than with the primary chronic progressive form. The clinical course and the grade of disability did not correspond to differences in MR imaging. Follow-up demonstrated that most lesions remain unchanged (72-79%); increases and decreases in the size of the plaques seem to depend on the clinical course. These results suggest that MR is the most sensitive technique for establishing the diagnosis of MS.

Evoked Potentials, Visual↗