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Biomedical subjects

W G Bensen

Publications and source records attributed to W G Bensen.

42 records · Page 3Linked to original sources
PubMed1984

HLA antigens and toxic reactions to sodium aurothiomalate in patients with rheumatoid arthritis.

HLA typing studies were performed on 60 consecutive patients with seropositive definite or classical rheumatoid arthritis (RA). Patients were treated with gold and were followed for a minimum of 18 months for identification of adverse reactions to gold therapy. HLA-DR3 was increased significantly in patients who developed gold induced rash, proteinuria or thrombocytopenia. On the other hand, the incidence of HLA-DR4 was lower in patients with these adverse reactions. Our results demonstrate that patients with RA carrying DR3 are at a higher risk of developing adverse reactions to gold. The most interesting finding was the low incidence of DR4 in patients who developed adverse reactions to gold, suggesting that DR4 positive patients may have some degree of protection against gold toxicity.

Adult↗
PubMed1984

Gold induced thrombocytopenia: platelet associated IgG and HLA typing in three patients.

Three patients who developed thrombocytopenia while taking gold therapy are reviewed. Bone marrow examinations at the time of thrombocytopenia revealed adequate numbers of megakaryocytes. Elevated levels of platelet associated IgG (PAIgG) were demonstrated in relationship to the thrombocytopenia. A response to prednisone therapy was seen with a rise in platelet count and a fall in PAIgG. All 3 patients were found to have the following alloantigens of the major histocompatibility complex, HLA-B8, DR3. These findings suggest that gold induced thrombocytopenia is immunologically mediated and possibly related to the genes of the major histocompatibility complex.

Arthritis, Rheumatoid↗
PubMedDate not supplied

Hemochromatotic arthropathy mimicking rheumatoid arthritis. A case with subcutaneous nodules, tenosynovitis, and bursitis.

A 63-year-old man developed symmetrical polyarthritis, subcutaneous nodules at the elbows, olecranon bursitis, and recurrent tenosynovitis. He was later discovered to have idiopathic hemochromatosis. Staining of the subcutaneous nodule revealed iron deposits. These manifestations which are common to rheumatoid arthritis may be seen in hemochromatotic arthropathy.

Arthritis↗
PubMedDate not supplied

Twice-daily dosing of enteric-coated aspirin in patients with rheumatic diseases.

To determine the feasibility of twice daily dosing of enteric-coated aspirin (EntrophenR), a preliminary trial on 10 patients with rheumatic diseases was conducted. Three plasma salicylate levels on 2 separate occasions, 1 day apart, were determined. In 9 of the 10 patients studied at steady-state, therapeutic levels were attained (15-30 mg/dl). There were no gastrointestinal side-effects. One case developed tinnitus which resolved with a small reduction in dosage. On the basis of this short-term study, twice-daily EC-ASA appears to be effective in maintaining adequate plasma salicylate levels, and it seems to compare favourably to ASA given in multiple daily doses. On a long-term basis, it may improve patient compliance.

Adult↗