A molecular model for transfer ribonucleic acid.
Explore the source record for details and available documents.
Models, Chemical↗
Biomedical subjects
W Fuller
Publications and source records attributed to W Fuller.
Stereochemical analysis of the specificity of pancreatic RNAse with polyformycin as substrate: differentiation of the transphosphorylation and hydrolysis reactions.
A stereochemical analysis of the substrate and inhibitor specificities of bovine pancreatic ribonuclease A is presented. A scheme is proposed in which the binding specificity for this protein-nucleic acid interaction is rationalized in terms of a simple system of H-bonds. The functional groups that govern substrate binding for transphosphorylation and hydrolysis, respectively, are considered and differentiated, and predictions are offered concerning the interaction of presumptive substrates with RNase.
Animals↗
Molecular conformations and structure transitions of RNA complementary helices and their possible biological significance.
Explore the source record for details and available documents.
Adenine Nucleotides↗
Conformation of the anticodon loop intRNA.
Explore the source record for details and available documents.
Amino Acid Sequence↗
Molecular and crystal structures of double-helical RNA. I. An x-ray diffraction study of fragmented yeast RNA and a preliminary double-helical RNA model.
Explore the source record for details and available documents.
Crystallography↗
Molecular and crystal structures of double-helical RNA. II. Determination and comparison of diffracted intensities for the alpha and beta crystalline forms of reovirus RNA and their interpretation in terms of groups of three RNA molecules.
Explore the source record for details and available documents.
Crystallography↗
Molecular and crystal structures of double-helical RNA. 3. An 11-fold molecular model and comparison of the agreement between the observed and calculated three-dimensional diffraction data for 10- and 11-fold models.
Explore the source record for details and available documents.
Crystallography↗
Molecular and crystal structures of double-helical RNA. IV. Molecular packing in crystalline fibres.
Explore the source record for details and available documents.
Crystallography↗
X-ray diffraction studies of double helical ribonucleic acid.
Explore the source record for details and available documents.
Chemical Phenomena↗
X-ray diffraction from the side-by-side model of DNA.
An intriguing topological problem posed by the double-helical Watson-Crick model of DNA is that of unwinding the intertwined strands during replication. Several workers have recently proposed novel side-by-side (SBS) structures for DNA. In all these models the two strands are joined by complementary Watson-Crick base pairs and the antiparallel polynucleotide strands alternate between short segments of right- and left-handed helix, thus both reducing the amount of intertwining and alleviating the unwinding problem. We show here that there are unacceptable discrepancies between the observed diffraction pattern of B-DNA and that calculated for the original SBS structure. We also describe a simple modification of this model which resolves some of the more serious discrepancies. However, the agreement is still markedly inferior to that obtained for a Watson-Crick model of DNA.
DNA↗
Retrieval of the critically ill in South Australia: a coordinated approach.
A system is described for the stabilization and evacuation of the critically ill in South Australia, with a discussion of experience in 278 patients. The integration of activities of peripheral medical practitioners, major teaching hospitals, and the ambulance transport authority (St John Ambulance Council) is paramount. Modes of communication are by "urgent line" telephone and radio. Advanced life-support equipment is portable, may be placed in any ambulance vehicle, and is used and maintained principally by the staff of intensive care units. The design characteristics of a suitable road vehicle and fixed-wing aircraft are considered, with emphasis on dimensions for the particular needs of advanced life-support. The cost of transporting such a patient is approximately two-thirds of an average bed day cost in a public hospital, plus the basic ambulance charge. The number of patients who need such measures is 0.2% of the total number of patients carried by ambulance per annum.
Adolescent↗