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Biomedical subjects

W Friend

Publications and source records attributed to W Friend.

12 recordsLinked to original sources
PubMed1998

Career momentum in midlife women: life context, identity, and personality correlates.

Women (N = 83) in their early 50s indicated whether they were increasing, maintaining, or decreasing momentum in their career. On the basis of their career momentum, women were classified into 3 groups and compared on work and family patterns, the importance of work to their identity, personality characteristics, and psychological well-being. Women with high career momentum were in higher status jobs and viewed their work as more central to their identity than women who were maintaining or decreasing their career momentum. Also, women with high career momentum scored higher on measures of self-acceptance, independence, and effective functioning in their early 50s and also rated their physical health higher than the other groups. Prospective longitudinal analyses showed that personality and life context patterns differentiated among the career momentum groups as far back as 30 years before the assessment of career momentum. The significance of the results for women's career development in midlife and coping with retirement is discussed.

Adaptation, Psychological↗
PubMed1993

Female transgenic mice carrying multiple copies of the human gene for S100 beta are hyperactive.

Down syndrome (DS) (trisomy 21) is the most frequent genetic cause of mental retardation in man. The gene coding for the beta subunit of human S100 protein (S100 beta) has been mapped to chromosome 21. The dimeric form of S100 beta may function as a neurotrophic factor in the CNS and may also influence the establishment of hippocampal long-term potentiation (LTP). To study the behavioral consequences of overexpression of S100 beta in an animal model, we derived four lines of transgenic mice carrying multiple copies of the human S100 beta gene. The human S100 beta gene was expressed in the brain of these mice in a cell-specific and gene-dose-dependent manner. The motor and posture patterns of 16-month-old transgenic mice and their control (non-transgenic) littermates were studied in two tests, open field and bar-crossing, in order to examine novelty induced exploratory activities. Transgenic female mice were significantly hyperactive in both tests in comparison with their female control littermates. These differences were independent of the line of origin of the mice suggesting a causal relationship between the observed hyperactivity and the presence of multiple copies of the integrated human S100 beta gene. In contrast, transgenic males were not hyperactive in comparison with controls. Neither male nor female transgenic mice displayed any coordination defects. We speculate about how an interaction between the effects of elevated S100 beta levels and female specific hormonal changes could have resulted in the observed female restricted hyperactivity.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗