Search PubMed⌕ Search

Biomedical subjects

W Franz

Publications and source records attributed to W Franz.

At least 19 recordsLinked to original sources
PubMed2000

Selective pressure-regulated retroinfusion of coronary veins as an alternative access of ischemic myocardium: implications for myocardial protection, myocardial gene transfer and angiogenesis.

There is renewed interest in the coronary venous system as an alternative access to ischemic myocardium. Selective pressure-regulated retroinfusion is a catheter-based approach which has been shown to increase the efficacy of retrograde oxygen delivery and drugs in experimental and clinical studies. Selective pressure-regulated retroinfusion may also target retrograde delivery of angiogenic growth factors and gene vectors to ischemic myocardium.

Angiogenesis Inducing Agents↗
PubMed1998

Frequency and phenotypes of familial dilated cardiomyopathy.

OBJECTIVES: This prospective study was performed to analyze the frequency and clinical characteristics of idiopathic dilated cardiomyopathy (DCM). BACKGROUND: Despite several previous reports on families with DCM, most cases are still believed to be sporadic, and specific clinical findings of the familial form are not well defined. METHODS: In 445 consecutive patients with angiographically proven DCM, we obtained detailed family histories to construct pedigrees and examined 970 first- and second-degree family members. RESULTS: Familial DCM was confirmed in 48 (10.8%) of the 445 index patients and was suspected in 108 (24.2%). The 156 patients with suspected or confirmed familial disease were younger at the time of diagnosis (p < 0.03) and more often revealed electrocardiographic changes (p = 0.0003) than patients with nonfamilial disease. Among the families of the 48 index patients with confirmed familial disease, five phenotypes of familial DCM could be identified: 1) DCM with muscular dystrophy; 2) juvenile DCM with a rapid progressive course in male relatives without muscular dystrophy; 3) DCM with segmental hypokinesia of the left ventricle; 4) DCM with conduction defects; and 5) DCM with sensorineural hearing loss. CONCLUSIONS: Up to 35% of patients with DCM may have an inherited disorder. Distinct clinical phenotypes can be observed in some families, suggesting a common molecular cause of the disease.

Adult↗
PubMed1995

[Clinical aspects and follow-up in dilated cardiomyopathy].

Dilative cardiomyopathy is a heterogeneous myocardial disease characterized by a depressed contractile function and ventricular dilation. The exercise intolerance of patients with dilative cardiomyopathy is partly explained by changes of metabolism and composition of skeletal muscle, whereas the physical findings result from progressive heart failure and cardiac remodeling. The clinical course of the disease is highly variable and prognostic indicators of progressive heart failure or cardiac arrhythmias are of little value in the assessment of cardiac risk in an individual patient. During recent years the mortality of patients with dilative cardiomyopathy was 5-15%, which appears to be lower than previously reported. The differences in mortality today and in previous years may be explained by a more precise and earlier diagnosis of the disease and possibly better treatment strategies. Patients with a severely depressed left ventricular function but a stable clinical course, a good hemodynamic response to therapy, and an oxygen uptake of > 12 ml/kg min can be followed without heart transplantation. It can be expected that the definition of the molecular causes of dilative cardiomyopathy will lead to a better classification of the patients and the development of more efficient treatment strategies.

Cardiomyopathy, Dilated↗
PubMed1994

A macroeconometric disequilibrium analysis of current and future migration from Eastern Europe into West Germany.

"This paper attempts to evaluate the impact of current and future immigration flows on major macroeconomic variables of the West German economy. The analysis is based on a macroeconometric disequilibrium model for the West German economy. This model is extended until 1995 and used for several simulation experiments. Special attention is given to the notion that the effects of immigration are regime-specific, i.e., they depend on the type of disequilibrium prevailing on the goods and labor market."

Demography↗
PubMed1994

[Combination of Cantrell pentalogy and amniotic band syndrome: a case report].

A case is reported of sonographic diagnosis of ADAM-complex (amniotic band syndrome) in combination with Cantrell-syndrome in the 19th gestational week. The ultrasonic investigation also showed a large defect in the fetal skull with encepholocele as well as a marked defect of the abdominal wall and chest with dislocation of the intestines, liver, and heart. The pregnancy was interrupted because of the severe fetal malformations. Aetiology and pathogenesis of such rare abnormalities and possible correlations between ADAM-syndrome and Cantrell-syndrome are discussed with reference to the literature.

Abnormalities, Multiple↗
PubMed1992

Differential impact of abortion on adolescents and adults.

The purpose of this study was to compare adolescent and adult reactions to abortion. A sample of 252 women from 42 states was obtained from a national survey of organizations serving as support groups for women who have had negative reactions to abortion. The age analysis was run using t-tests. Results indicated that the adolescents were significantly more likely to be dissatisfied with the choice of abortion than were the older subjects, to have abortions later in the gestational period, to be dissatisfied with services at the time of the abortion, to feel forced by circumstances to have the abortion, to report being misinformed at the time of the abortion, and to report greater severity of psychological stress. The conclusions suggest that the adolescents' problems may be due to a combination of developmental limitations and the nature of counseling at the time of the abortion.

Abortion Applicants↗
PubMed1991

[Characteristics of alcohol withdrawal delirium in surgical patients and recommendations for treatment].

An alcohol withdrawal syndrome affects the patient in a 'vulnerable phase' either after an operation or posttraumatically. It can be shown pathophysiologically, that the symptoms are caused by a hyperactivity of the central sympathetic nervous system and a disbalance of the neurotransmitters. As for these complex symptoms, a multi-layered treatment is required. We report on our experiences with 23 patients who were treated in our intensive care unit. The treatment included a benzo-diazepine and a drug effecting central alpha 2-receptors. Only three of these patients had to be intubated or ventilated. Because of the induced bradycardia monitor observation was required in all cases. The patients could be wakened up at any time and thus were co-operative for basic care. One patient died of pulmonary embolism, a second patient died of cardiovascular failure as a consequence of cardiac insufficiency.

Adult↗
PubMed1987

[Initial experience using the new Weill cementless threaded ring in acetabulum replacement].

First experiences with a new threaded ring for acetabulum arthroplasty developed by D. Weill are reported. These experiences are based on 59 implantations, whose clinical courses and complications are lined out. The Weill acetabular arthroplasty turned out to be a very valuable device for both primary and revision hip arthroplasty. It provides all advantages of cementless fixation. The fixation is gained by a selftapping thread on the outside of the titanium ring. Thus a very high primary stability is achieved. A bone grafting possibility in the fossa region is provided. The relative less tolerance of the Weill ring concerning improper orientation predisposing to dislocation is a disadvantage as we experienced.

Acetabulum↗
PubMed1984

[Not Available].

Explore the source record for details and available documents.

Education, Medical↗
PubMed1982

Effects of forced convection of heated air on insensible water loss and heat loss in preterm infants in incubators.

To assess the effect of forced convection of heated air exchange in preterm infants in conventional incubators, we measured insensible water loss and total heat loss in preterm infants in a conventional forced convection incubator (air velocity 15 to 25 cm/second) and in a specially constructed still-air incubator (air velocity 0 to 2 cm/second) at equal operative temperature and humidity. Under the forced conditions, insensible water loss in the preterm infants increased by a mean 52% from 1.04 +/- 0.24 (mean +/- SD) to 1.58 +/- 0.51 ml/kg/hour (P less than 0.001). The ensuing increase in evaporative heat loss was partly reflected in the small but significant increase in total heat loss from 1.65 +/- 0.47 to 1.80 +/- 0.44 kcal/kg/hour (P less than 0.02). In the forced convection incubator, the increased evaporative heat loss in preterm infants was apparently partly compensated by a decreased nonevaporative heat loss. If reduction of insensible water loss is required, preterm infants should not be subjected to forced convection in incubators.

Air↗
PubMed1981

Employment policy and labor supply of foreign workers in the Federal Republic of Germany: a theoretical and empirical analysis.

"This study is an attempt to investigate the economic determinants of international immigration and remigration into and out of the Federal Republic of Germany. Moreover, employment policy measures with respect to foreign workers are described and their impact on the inflow and outflow of guest workers [is] analyzed." The author notes that the ability of the government to influence migration flows through legislation is limited because of the free movement of labor within the Common Market countries. It is suggested that in-migration of foreign labor slows wage increases for the native worker, may retard rationalization, and increases the social costs of unemployment, particularly during periods of recession.

Demography↗
PubMed1977

[Modification of the rate of complications in the inflammatory adnexa process and pregnancy interruption].

On account of the case histories of the obstetrics and gynaecological klinic of the States Klinicum Berlin-Buch, the influencing of the complications rate by chronic adnex processes among the pregnant women who came for interruption, was examined. In 1974 and 1975 about 3118 interruptions with vacuum exhaustion and after-curettage, were carried out. During the stationary treatment, there were a total of 195 cases (6,2%) with complications, which later increased by 286 cases (19,1%), within 3 months after the interruption of their pregnancies. The complication's rates post interruption by patients with chronic recidive adnex-process are 27 cases (10,4%) only a little higher than those by the women with clear anamnesis (102 cases=8,2%). Therefore chronic adnex processes do not constitute contraindications for pregnancy interruptions.

Abortion, Induced↗