Search PubMed⌕ Search

Biomedical subjects

W Forth

Publications and source records attributed to W Forth.

160 records · Page 9Linked to original sources
PubMedDate not supplied

The longitudinal distribution of cadmium, zinc, copper, iron, and metallothionein in the small-intestinal mucosa of rats after administration of cadmium chloride.

Different routes of Cd intake may influence the intestinal distribution of Cd, metallothionein (MT), and trace metals differently. Therefore, we compared the effects of parenteral and enteral administration of Cd on the distribution of trace metals and MT along the small intestine. In a first experiment three groups of rats were employed: a control, one receiving CdCl2 within the drinking water, and another receiving sc injections of CdCl2. In a second experiment, rats were fed three different diets with either 0, 0.3, or 1 mmol CdCl2/kg for one and two weeks to study the time- and dose-dependent effects of orally administered Cd. Metal concentrations (Cd, Zn, Cu, Fe) were measured by atomic emission spectrometry and MT was determined by radioimmunoassay. Intestinal MT levels did not show proximodistal gradients in controls or after sc administration of Cd, but orally administered Cd increased mucosal MT levels longitudinally from the duodenum to the ileum. Cd levels paralleled those of MT. Compared with the metal concentrations in the controls, sc administration of Cd did not change intestinal Zn, Cu, and Fe levels. Oral administration of Cd, however, increased Cu and decreased Fe levels in the intestinal mucosa significantly. The second experiment revealed that only high dietary concentrations of Cd increase intestinal Cd and MT levels longitudinally toward the distal parts, whereas at lower dietary concentration the longitudinal distribution was reversed. This shows that different routes and doses of Cd intake lead to a different trace metal and MT distribution and emphasizes the role of dietary Cd in the local induction of small-intestinal MT.

Administration, Oral↗
PubMedDate not supplied

[Topical use of salicylic acid esters in pharmacotherapy--pharmacologic principles].

The local application of 2-hydroxyethyl salicylic acid esters and ether salicylic acid esters offers the possibility of therapy with salicylic acid that avoids a systemic burden of the body. This justifies the unavoidable uptake of ethylene glycol. Under therapeutic conditions and following guidelines for the recommended amount and frequency of application, the amount of ethylene glycol taken into the organism appears to be without risk for the user.

Administration, Topical↗