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Biomedical subjects

W Fong

Publications and source records attributed to W Fong.

24 records · Page 2Linked to original sources
PubMed1990

Low holotranscobalamin II is the earliest serum marker for subnormal vitamin B12 (cobalamin) absorption in patients with AIDS.

In AIDS, as previously found in pernicious anemia (PA), the earliest serum marker of subnormal vitamin B12 (cobalamin) absorption, and therefore of negative B12 balance, is low serum holotranscobalamin II (holo-TC II; B12-TC II) despite normal total serum B12 level, normal serum homocysteine, and normal classic (oral free radio-B12) Schilling test. This may be accompanied by subtle and insidious damage to hematopoietic, immunologic, neuropsychiatric, nutritional and alimentary systems, confirmed by correction on therapeutic trial with B12 therapy. Our studies suggest such selective B12 deficiency occurs in about half of the HIV-1 infected, in part due to frequent depression of B12 absorption by HIV-1 attack on the gastric mucosa and/or opportunistic infection attack on the small bowel, and in part due to a telescoping of the continuum of the stages of negative B12 balance in relation to damage to B12 delivery by the infective and/or systemic disease process. In AIDS, when total serum B12 is normal despite tissue depletion of B12, if the classic Schilling test does not reveal subnormal food B12 absorption, the food Schilling test does. We hypothesize that DNA-synthesizing cells of the hematopoietic, immunologic, neurologic and other systems which have surface receptors solely for holo-TC II, and which have low B12 stores, rapidly become dysfunctional due to B12 deficiency when holo-TC II is low, while cells (such as liver cells) which also have surface receptors for holohaptocorrin (B12-haptocorrin) remain B12-replete. We believe this to be another example of the concept of selective nutrient deficiency in one cell line but not another.

Absorption↗
PubMed1976

Elemental analysis by energy dispersive x-ray: a significant factor in the forensic analysis of glass.

Eighty-one glass samples were analyzed by EDX; two were indistinguishable. However, when the physical properties of the glass samples were considered, all glass samples were distinguishable from each other. The need to examine glass with respect not only to physical properties but also to elemental composition has been demonstrated. The authors believe that if glass is examined only by density and refractive indexes it is quite possible to conclude incorrectly that glass samples with the same physical qualities could have originated from the same source. To confirm that the glass specimens may have in fact originated from the same source their elemental compositions in addition to density and refractive indexes must be determined. The analysis by EDX of glass samples can selectively eliminate most specimens on the basis of elemental differences. If this step is performed prior to refractive index or density measurements considerable time savings can be realized in casework situations.

Forensic Medicine↗