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Biomedical subjects

W Fisher

Publications and source records attributed to W Fisher.

At least 73 records · Page 4Linked to original sources
PubMed1986

A treatable language disorder: pharmacological treatment of pervasive developmental disorder.

Results of treatment of four patients are described. All of the patients had pervasive developmental disorder (PDD), a tic disorder, and a characteristic pattern of speech and language impairment. The patients were treated with haloperidol for their tic disorders, and concomitant with the reduction of the frequency and severity of tics was marked improvement in language. The patients averaged 3 months of language gain for each week of speech therapy directly after the initiation of haloperidol treatment for tics. Progress in speech and language therapy was extremely slow during the years prior to treatment with haloperidol. To the authors' knowledge, no language disorder has been described in the literature which shows such a predictable and marked response to pharmacological treatment. The authors hypothesize that tic disorders in individuals with PDD may be a marker for a more positive response to dopamine antagonists like haloperidol.

Child↗
PubMed1986

Anticonvulsant medications: an iatrogenic cause of tic disorders.

A review of the relationship between anticonvulsant medications and tics is presented. Data on 5 patients in whom anticonvulsants, either caused tics or exacerbated existing tic disorders is discussed. Discontinuation of the medication resulted in a decrease in the frequency of tickings in all patients. The effects of anticonvulsants on the reticular system are discussed. It is felt that it may be important for clinicians to consider carefully the use of barbiturate anticonvulsants, especially phenobarbital, in children with tics or a family history of tics. Tic disorders caused or exacerbated by exposure to anticonvulsant medications appear to be more common than previously reported, and in some patients the tics may not remit with discontinuation of the medication.

Anticonvulsants↗
PubMed1986

Pseudohemiparesis and Tourette syndrome.

Three patients with Tourette syndrome and transient recurrent hemiparetic posturing (pseudohemiparesis) are presented. The transient nature of this posturing is not consistent with a static central nervous system deficit. It is felt that the Tourette syndrome symptomatology and pseudohemiparesis share a common pathophysiology. The inclusion of pseudohemiparesis in the differential diagnosis for cerebral palsy is suggested.

Adult↗
PubMed1986

Random prospective study of vindesine versus vindesine plus high-dose cisplatin versus vindesine plus cisplatin plus mitomycin C in advanced non-small-cell lung cancer.

In this phase III randomized study, 124 evaluable patients with unresectable non-small-cell lung cancer (NSCLC) were randomized to vindesine v cisplatin (120 mg/m2) plus vindesine v cisplatin (60 mg/m2) plus vindesine plus mitomycin C. The objective response rate for cisplatin and vindesine was 27% v 20% for cisplatin, vindesine, and mitomycin C, and 14% for vindesine alone (P = .25 for cisplatin and vindesine v vindesine). The percentage of patients having stable disease (no progression for a minimum of 3 months) was 20% (cisplatin and vindesine), 27% (cisplatin, vindesine, and mitomycin C), and 26% (vindesine alone), respectively. The median survival time for vindesine was 18 weeks, compared with 26 weeks for cisplatin and vindesine and 17 weeks for cisplatin, vindesine, and mitomycin C. Overall survival was not statistically different for cisplatin plus vindesine v vindesine (P = .65). There was no evidence for improved duration of remission or survival of responders with the cisplatin (120 mg/m2) and vindesine arm. This study failed to demonstrate sufficient therapeutic benefit for cisplatin and vindesine (+/- mitomycin C) compared with single-agent vindesine to justify the increased cost and toxicity of these combination regimens.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1983

Family planning and female sterilization in the United States.

This report critically examines the issue of sterilization in the United States based on data from the National Survey of Family Growth, Cycles I and II, spanning the years 1973 to 1976. Of particular concern is analysis of sterilization rates as they vary across categories of race, socioeconomic status, welfare status, number of children and desire for the service. The development of a framework containing competing theories and philosophies, based upon previous literature in the area, provides a useful paradigm for an understanding of the significance of sterilization rates. The methodology includes bivariate techniques involving tabular analysis as well as multivariate techniques through the use of logistic regression analysis. Findings support hypotheses related to class factors and parity, while the racial and altruistic interpretations are not supported. Policy implications and areas requiring further research are specified.

Adolescent↗
PubMed1980

Drugs, alcohol and violence in 604 male offenders referred for inpatient psychiatric assessment.

Of 604 White and Coloured male offenders in the Cape referred for inpatient psychiatric observation, 52% habitually indulged heavily in alcohol, drugs (mostly dagga (cannabis)) or both. Indulpence in alcohol alone was frequently associated with violence and sexual assaults, alcohol and drugs together less, and drugs alone least. Those who indulged in drug-taking (i.e. dagga, LSD and hard drugs) were less frequently associated with violence, rape and other sex crimes than were those who did not; 60% of sex offenders were non-abusers. Out of 101 severely psychopathic patients in the sample, only 1 who indulged in drugs but not alcohol was charged with a crime of violence or sex. There was no evidence of a potentiating action between alcohol and dagga towards violent behaviour. Dagga appeared to diminish the action of alcohol, and may inhibit urges toward violence and rape in aggressive persons and psychopaths. Drugs did not release or set off violent reactions, and drug indulgence was associated with stealing without violence. Some implications for forensic psychiatry and arguments about drug indulgence as an extenuating factor in serius crime are discussed.

Alcohol Drinking↗