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Biomedical subjects

W Fischbach

Publications and source records attributed to W Fischbach.

At least 55 records · Page 3Linked to original sources
PubMed1998

[Helicobacter and lymphoma].

The gastrointestinal tract represents the most common extranodal site of malignant non-Hodgkin's lymphoma. Epidemiological, histomorphological, molecular biological and experimental animal studies undoubtedly underline the important role of Helicobacter pylori for the development and progression of primary gastric lymphoma of MALT (mucosa-associated lymphoid tissue). Eradication of Helicobacter pylori is an important therapeutic option in low-grade gastric, MALT lymphoma of localized stage E I.

Cell Transformation, Neoplastic↗
PubMed1998

[Diagnostic value of stomach biopsy in comparison with surgical specimen in gastric B-cell lymphomas of the MALT type].

Diagnostic und therapeutic management of gastric lymphomas of the mucosa-associated lymphoid tissue type (MALT-type lymphomas) is often based exclusively on the evaluation of biopsy material. To evaluate the diagnostic value of gastric biopsies in gastric MALT-type lymphomas, biopsies--on average six per patient--and subsequent surgical specimens of 64 patients were compared at the Institute of Pathology, University of Würzburg. Tumor diagnosis and tumor gradind were assessed. Using biopsy specimens, primary gastric MALT-type lymphomas were correctly diagnosed by local pathologists in 69% of cases, but correctly graded as low-grade, high-grade or secondary high-grade lymphomas in only 41%. When immunohistochemistry and molecular biological techniques were applied in addition to conventional histology, diagnosis of gastric MALT-type lymphoma was achieved in biopsies in 95% of cases at the Institute of Pathology Würzburg, but correct grading in only 73%. In secondary high-grade MALT-type lymphomas, both components--the high-grade and the low-grade component--were identified in gastric biopsies in only 33% of cases. Diagnostic accuracy in gastric lymphomas based on biopsies is limited by biopsy artefacts, but improved by using immunohistochemistry and molecular biological techniques. Particularly in secondary high-grade MALT-type lymphomas the correct diagnosis is often missed when using biopsies, due to a low number of biopsy specimens.

Biomarkers, Tumor↗
PubMed1998

Helicobacter pylori and lymphoproliferative disorders.

Primary gastric lymphoma of mucosa associated lymphoid tissue represent a distinct entity which is documented by their own histological classification. Our knowledge about all aspects of these lymphoma has substantially increased during the last few years. Epidemiological, histomorphological, molecular-biological and experimental data clearly underline that Helicobacter pylori infection of the gastric mucosa without doubt plays an important role both in the development and progression of MALT lymphoma. Considering histological malignancy (low grade and high grade lymphoma) and dissemination of the disease (stage) as decisive prognostic factors and therapeutical determinants, endoscopic bioptic diagnosis as well as endoscopic ultrasound are of major importance in establishing diagnosis and clinical stage. In the case of localized low grade lymphoma, eradication of Helicobacter pylori offers a promising therapeutic option. Surgical resection and radiochemotherapy have proven to be effective treatment modalities. There is a need for randomised trials to establish whether operative or conservative therapeutic strategies have to be favoured in the future.

Antibodies, Bacterial↗
PubMed1998

[Rare cause of acute pancreatitis: phytobezoar in an intraluminal diverticulum in type I duodenal atresia, intestinal malrotation and rudimentary pancreas anulare].

A 28-year-old woman was hospitalized because of the third episode of acute pancreatitis. No hint for an extrinsic cause was evident. Under conservative treatment pancreatitis and signs of intestinal obstruction were persisting. Imaging procedures showed an undefinite mass in the neighbourhood of the pancreatic caput. Endoscopy revealed a phytobezoar in a wind sock web, a special form of congenital duodenal atresia. Obstructing the papilla of Vater the bezoar had caused acute pancreatitis. After endoscopical removal the symptoms of pancreatitis disappeared immediately. Web excision and duodenoduodenostomy were performed. At operation further anomalies of the gastrointestinal tract frequently associated with duodenenal atresia were found.

Acute Disease↗
PubMed1998

[Current aspects of pathogenesis, diagnosis and therapy of primary MALT stomach lymphomas].

Primary gastrointestinal lymphoma of MALT occupy a special position which is documented in their own histological classification. Our knowledge about pathogenesis, biological and therapeutical behaviour of this lymphoma entity has increased substantially during recent years. Considering epidemiological, histomorphological and experimental data Helicobacter pylori infection undoubtless plays an important role in the development and progression of gastric MALT-lymphoma. In view of histological malignancy (low or high grade) and dissemination of the disease (stage) as decisive prognostic factors and therapeutical determinants endoscopic-bioptical diagnosis as well as endoscopic ultrasound are of major importance. In case of localized low-grade lymphoma eradication of Helicobacter pylori offers a promising therapeutic option. Surgical resection and radiochemotherapy have proven to be effective treatment modalities. There is a need for randomized trials to clarify if operative or conservative therapeutic strategies have to be favored in the future.

Combined Modality Therapy↗
PubMed1996

[MALT-lymphoma--conservative therapy].

Primary gastrointestinal lymphoma of the MALT (mucosa-associated lymphoid tissue) are nowadays regarded as a distinct entity with specific morphological, biological and clinical characteristics. Therapeutic strategies are based on their histological grade (low or high malignancy) and stage of the disease. They include surgical resection and/or radiotherapy for the local tumor control as well as chemotherapy in the case of disseminated disease or high malignancy. Currently, eradication of Helicobacter pylori offers another promising therapeutic option in low malignant gastric lymphoma of stage EI.

Algorithms↗
PubMed1996

[Helicobacter pylori infection and gastrointestinal lymphomas].

Primary gastric lymphoma of the MALT (mucosa-associated lymphoid tissue) is nowadays considered a distinct entity with specific morphological, biological and clinical characteristics. In the pathogenesis of gastric MALT lymphoma, Helicobacter pylori infection plays an important conditioning role, In the case of low grade gastric lymphoma of stage E I, eradication of Helicobacter pylori offers a promising therapeutic option.

Algorithms↗