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Biomedical subjects

W Felber

Publications and source records attributed to W Felber.

At least 19 recordsLinked to original sources
PubMed1999

Olanzapine-induced agranulocytosis.

The antipsychotic drug olanzapine was developed to reduce the risk of haematotoxicity. We report a case of agranulocytosis induced by olanzapine.

Adult↗
PubMed1998

Differences in whole blood serotonin levels based on a typology of parasuicide.

Suicidal behavior has to be considered as a multifactorial phenomenon, which can be analyzed in a classifying-phenomenological manner. We have examined the relation of parasuicide typology to whole blood concentrations of serotonin, HVA, and tryptophan in 58 patients classified into 4 groups of parasuicide typology compared to 22 nonsuicidal depressed patients and 20 healthy subjects. Suicidal patients classified as impetuous, desperate and ambivalent types had significantly reduced whole blood 5-HT levels in comparison with the appealing type as well as nonsuicidal subjects. No differences were detected in the HVA content, but whole blood tryptophan concentrations were significantly reduced in impetuous suicidal patients and depressed patients compared to healthy subjects. This study provides evidence for reduced whole blood serotonin content based on different types of parasuicide.

Adult↗
PubMed1996

How to interpret findings on mortality of long-term lithium treated manic-depressive patients?! Critique of different methodological approaches.

Many studies have shown that patients with affective disorders have a mortality markedly higher than that of the general population. Studies of manic-depressive patients given prophylactic lithium treatment have yielded varying results. Some authors have reported mortalities which were more than four times that of the general population. Others have found mortalities which did not differ significantly from that of the general population. In order to examine these discrepancies we re-analysed the data of a previous study by IGSLI, using three different methods to calculate the Standardised Mortality Ratio (SMR). The data base was enlarged by adding mortality data from two additional centres. The results indicate that the discrepancies may result from the common use of a 'cumulative' approach which produces a distortion of the data if the treatment duration is not taken into consideration properly. An analysis which eliminates this artefact and takes the treatment duration into account ('year-by-year' approach) provides the strongest evidence that the mortality of lithium treated patients is not significantly different from that of the general population.

Adult↗
PubMed1995

[The psychiatric emergency].

The psychiatric emergency is primarily treated by the general practitioner. Particular treatments are prepared which are applied in characteristic syndromes. Basic psychopharmacological and legal knowledge needs to be renewed in a regular manner.

Alcohol Withdrawal Delirium↗
PubMed1989

[Results of the use of lithium to prevent recurrence of affective psychosis].

The efficacy of lithium treatment in preventing relapse in phasal psychoses was tested by the re-examination of 99 patients at a Dresden clinic whose treatment had on average exceeded ten years. Results and progress were compared with those of patients starting treatment since the introduction of the lithium treatment in the year 1979. Phase or subphase frequency and duration, conditions of treatment, suicide attempts, unfitness for work, and registration as a disabled person were among the aspects considered.

Bipolar Disorder↗
PubMed1988

[Lithium strumas and their psychiatric relevance].

Basing on 172 clinically recorded goitres among 787 patients treated with lithium (21.9%) we studied the question as to whether goitre formation due to lithium has any relevance within the concept of relapse prevention in affective disorders. A statistical comparison of essential disease parameters between the group of patients suffering from struma (goitre) and the total group shows that there is no special type or course of affective disorder with a particular affinity to the development of struma. Likewise, we can conclude from a comparison of treatment course and effectively parameters between both groups that development of struma under influence on the course of treatment or on the efficiency of prophylaxis. The results point to an irrelevance of lithium goitre in respect of psychiatric effects (this does not imply that it is irrelevant in respect of general medical aspects or endocrinology).

Adult↗
PubMed1987

[Lithium prevention of depression 100 years ago--an ingenious misconception].

The rediscovery of C. Lange's book "Uber periodische Depressionszustände und ihre Pathogenesis auf dem Boden der harnsauren Diathese", Copenhagen 1886, in a German translation by H. Kurella in 1896, gave rise to appreciate its value, to make its misconception intelligible, and to write down the author's and the translator's course of life. In his booklet Carl Lange gives a specification of depression in a most modern form. It is thrilling to read his report on about 2000 depressed out-patients successfully treated over a 20-year-period - from today's point of view lege artis - with lithium carbonate as a long-term-prophylaxis for recurrent depression. His intricate misconception is based upon his therapeutic orientation of treating gout and "uric acid diathesis", respectively. This conception of depression as "brain gout", part of an inflationary enlarged pathogenesis of numerous internal, neurological, and other diseases, had been set up by Garrod. "Brain gout" was a curiosity in the established psychiatry and disappeared from scientific thinking with a new medical knowledge of gout and rheumatism. With that, of course, the pioneering knowledge of the effectiveness of lithium disappeared too.

Denmark↗
PubMed1981

[Agreement between 2 diagnostic intelligence test procedures (HAWIE and MWT-B) in a sample of patients with pronounced psychopathology].

In the article a random test in 100 psychopathologically conspicuous patients with the HAWIE and MWT-B methods was studied and the two methods compared. The results obtained with the two procedures show a high degree of agreement (measure correlation coefficient 0.81). The use of the MWT-B for an appraisal of the general intellectual level appears to be justified (also) in these patients, providing they are prepared for co-operation and do not show pronounced impairments in the range of basic performance conditions. Significant deviations were only found for the group of patients below 20 years.

Adult↗
PubMed1976

[Extrapyramidal syndromes as side-effects of metoclopramide (Cerucal) medication].

The authors, by describing their own observations made on eight patients showing extrapyramidal syndromes as side effects of metoclopramide (Cerucal) medication, report the various kinds of possible side effects, discussing their conformity with side effects produced by conventional neuroleptics and showing methods of treatment. Metoclopramide is known to produce three froms of extrapyramidal and motor side effects, namely: 1. Dyskinetic syndrome; 2. acathisia; and 3. Parkinson's syndrome. Therapy is in the following form regardless of the particular side effect produced by the said drug: 1. Administration of antiparkinsonian remedies; 2. administration of coffein; and 3. discontinuation or drastic reduction, respectively, of the daily dose of Cerucal.

Adult↗