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Biomedical subjects

W Fajman

Publications and source records attributed to W Fajman.

9 recordsLinked to original sources

Fundamentals of 180 degree acquisition and reconstruction in SPECT imaging.

The accuracy of the reconstructed images obtained from a 180 degrees SPECT acquisition is directly related to the effects of resolution and attenuation in the acquired projection data. Computer simulation studies show that the tomographic point spread functions and the quality of 201Tl myocardial perfusion transaxial images depend upon the specific 180 degrees arc used for reconstruction. Significant distortions are predicted in 201Tl myocardial images reconstructed from both 180 degrees and 360 degree scans; with signal to noise being significantly better for 180 degree scans. An anterior 180 degrees scan with a starting angle between right lateral and 45 degrees RAO in 201Tl myocardial imaging is recommended. Reconstructed images acquired from 180 degrees and 360 degree elliptical orbits are predicted to show more distortion than those obtained from circular acquisitions.

Heart↗

Radionuclide angiography of the liver and spleen. Noninvasive method for assessing the ratio of portal venous to total hepatic blood flow and portasystemic shunt patency.

Radioactivity verus time curves were generated for the first pass of technetium-99m pertechnetate through the left ventricle, kidneys, spleen and liver, after a 20 mCi peripheral intravenous bolus injection. The rate of change of radioactivity in these organs before recirculation is proportional to blood flow through the organ. The hepatic perfusion index, defined as the ratio of portal flow to total hepatic blood flow, was correlated with the angiographic grade of portal perfusion. The hepatic perfusion index in seven normal subjects was 66.0 +/- 3.4 percent (mean +/- standard error of the mean), and in 22 cirrhotic patients with decreasing angiographic perfusion of grades 1 to 4 the index was 54 +/- 4.6, 37 +/- 2.6, 17 +/- 4.7 and 3 +/- 1.1 percent, respectively. The correlation between the calculated perfusion index and the angiographic grade of portal flow was highly significant (p less than 0.001). The passage of radionuclide through the spleen differed before and after shunt surgery in patients with portal hypertension. The slope to height ratio, based on the downslope of the splenic curve, was significantly greater (p less than 0.01) in the shunted patients and provided a simple index for assessing shunt patency.

Adult↗

"Doughnut" sign in brain scanning.

The significance of the "doughnut" sign at present is relegated to characterizing the morphology of a lesion. The use of the "doughnut" sign in differential diagnosis should not be attempted except in specific clinical contexts, and never excluding other evidence. The "doughnut" sign in scanning together with other studies such as angiography and computerized axial tomography gives additional characterizing data in the neuroradiologic evaluation of a patient.

Adult↗