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Biomedical subjects

W Fabian

Publications and source records attributed to W Fabian.

At least 37 records · Page 2Linked to original sources
PubMed1988

[Occult rectal cancer in Crohn disease].

An adenocarcinoma in the anorectal region was an accidental histological finding recorded from a female patient who had suffered Crohn's disease for many years. A rectovaginal fistula in the neighbourhood was also discovered but was in no way anatomically related to the carcinoma. Reference is made to an account of the literature for discussion of pathogenetic factors for the development of Crohn-associated gastro-intestinal carcinomas and conclusions that ought to be drawn for diagnosis and therapy when it comes to patients with Crohn's disease. Definite assessment is not yet possible for the very low number of cases so far observed.

Adenocarcinoma↗
PubMed1981

[Can an electric pacemaker be powered by the body's own energy? A medico-technical speculation].

The basic feasibility to power a cardiac pacemaker system through energy provided by vital body functions is demonstrated. Cardiac action and the respiratory apparatus are evaluated as power sources. Electromagnetic induction and the piezo-electric effect are discussed as ways of transducing mechanical into electrical energy. Size as a limiting factor in adapting technical systems to biological power sources is assessed, while criteria for a feasible solution are defined.

Bioelectric Energy Sources↗
PubMed1980

[Pharmacokinetic problems in surgery].

The article deals with the shortcomings of pharmacokinetic models in predicting tissue-concentrations of drugs. Several examples are shown from our group that cooperation of surgeons and pharmacokinetic researchers is necessary to overcome these shortcomings.

Biological Availability↗
PubMed1980

[Surgical treatment of cardia and esophageal neoplasms].

From 1964-1978 458 patients were operated for carcinoma of the cardia or esophagus at the surgical clinic, Krankenhaus Nordwest, Frankfurt/M. Indication, preoperative treatment and operative procedures are discussed. In 117 cases, an abdominal thoracic resection or a resection of the cardia was performed. In a higher frequency of incurable cases an esophageal endoprosthesis was implanted. The lethality rate was 20,5% after resection. Nearly half of the operated patients survived for two years. 36% of the patients were still alive five years following abdominal thoracic resection and 21% following cardia resection. Despite a relatively high surgical risk, resection seemed to be the appropriate procedure as proven by the good long term results.

Cardia↗
PubMed1980

[Early therapy with immunoglobulins after extensive abdominal operations. A random study (author's transl)].

A random study with 100 patients was conducted to show whether the immunoglogulin Gamma Venin, when given after rectum extirpation, has an effect on wound healing and other infections. The patients in the test group received 10 g of Gamma Venin within the first 48 h after surgery. The number of days with purulent wound secretion were reduced to 0.71 (test group) as opposed to 7.61 (control) with statistical significance. Primary wound healing was 37% in the test group and 9% in the control group (P < 0.01). Other infections occurred in a similar range. The time of hospitalization was 3.44 days less than in the test group (P < 0.01).

Abdomen↗
PubMed1980

[Massive hemorrhage of the esophageal varix: standardized treatment and long-term results after portosystemic anastomosis (author's transl)].

A reexamination was conducted on 90 of 231 patients who had undergone portal-systemic shunt operations 2-15 years ago in our hospital due to massive esophageal varix bleeding. The results show that decompressing procedures represent the only therapeutic principle successfully preventing recurrence of massive esophageal hemorrhage over an extended period of time. Postoperative encephalopathy occurred relatively infrequently. This finding imposes considerably restraint on the use of this term as a weighty argument against portocaval shunts, especially because nitrogen substances are often known to pass unchanged from the intestinal tract to the vena cava and thus ultimately to the brain in patients with liver cirrhosis not undergoing surgery. The possibility of preventing recurrence of massive esophageal hemorrhage by protal decompression is meant to relieve the patient's constant fear of an incident putting his liver in jeopardy.

Brain Diseases↗
PubMed1975

[O2 pressure on liver surface following portacaval anastomosis and administration of vasoactive substances in dogs with normal livers].

1) Following acute portocaval anastomosis in healthy dog liver tissue - pO2 drops by 23%, an extent regulary occuring in hour long laparotomy. 2) Intravenous octapressin lowers splanchnic blood flow, concomitantly liver blood-flow and tissue -pO2 is decreased. 3) In contrast to octapressin orciprenalin improves liver blood-flow and tissue-pO2. 4) By shunting of arterial blood through the gut norepinephrine causes a rapid and lasting elevation of liver tissue-pO2.

Animals↗