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Biomedical subjects

W F Smith

Publications and source records attributed to W F Smith.

14 recordsLinked to original sources
PubMed1998

A review of tumor suppressor genes in cutaneous neoplasms with emphasis on cell cycle regulators.

Cells normally have five options. These include renewal or proliferation, terminal differentiation, quiescence, senescence, and apoptosis. Many factors interact with cell cycle regulators to direct the cells toward these different options. Tumor suppressor genes play a pivotal role in this process. Alterations in these genes may limit the options that cells have and thus play a significant role in the multistep process of carcinogenesis. We will focus on tumor suppressor genes and especially tumor suppressor genes that interact directly with the cell cycle proteins.

Cell Cycle Proteins↗
PubMed1997

Cutaneous aspergillosis.

The authors present a patient with advanced acquired immunodeficiency syndrome who developed a cutaneous lesion under the transparent dressing of a venous catheter. Histologic examination of the lesion revealed suppurative granulomatous inflammation in the dermis with numerous branching hyphae within the follicular infundibulum. A culture of the biopsy material grew Aspergillus fumigatus. Aspergillus must be considered in the differential diagnosis of cutaneous lesions in patients infected with the human immunodeficiency virus, especially when the lesion occurs under an occlusive dressing.

AIDS-Related Opportunistic Infections↗
PubMed1996

Bacterial discitis caused by limb gangrene requiring below-knee amputation.

Two patients presented with disabling back pain and were unable to participate in physical therapy activities after being admitted to an acute rehabilitation center. Both patients had bacterial discitis of the lumbar spine that was apparently caused by infected ischemic limb tissue, ultimately removed at below-knee amputation. The literature describes many cases of bacterial discitis infected from many sources, but not from ischemic limb tissue requiring subsequent amputation. Many such cases may exist, however, and earlier recognition of this condition will enable appropriate treatment before vertebral destruction and/or neurological sequelae.

Aged↗
PubMed1972

Cloxacillin and sodium fusidate in management of shunt infections.

The effectiveness of two oral antibiotics, cloxacillin and sodium fusidate, has been evaluated in the treatment of shunt infections among 37 patients allocated at random to two treatment groups. Both proved to be safe bactericidal agents giving adequate serum M.I.C. when taken by mouth. Treatment should always be started on the basis of the clinical presentation without waiting for the bacteriologist's report. The commonest infecting organism is Staphylococcus aureus. Nine shunts were lost in this study, eight through Staphylococcus aureus infection. The nasal carrier state is of considerable importance in perpetuating these shunt infections.

Arteriovenous Shunt, Surgical↗
PubMed1970

Giant thymoma.

Explore the source record for details and available documents.

Adolescent↗
PubMedDate not supplied

Epidemiologic study of 19-month-old Edmonton, Alberta children: caries rates and risk factors.

A random sample of 938 19-month-old Edmonton children and their parents/caretakers were studied. Parents were interviewed and children were examined. Specimens for a caries activity test were collected at the examination. Results indicated 25 percent of the children had moderate to high caries activity, as shown by the Cariostat, with 4.6 percent showing decalcification lesions and frank caries. Early caries (BBTD) were found to be related to bottle feeding practices, discomfort with allowing the child to cry, and with mother being foreign-born. Foreign-born status was associated with the above parenting practices. Preferences for preventive recommendations and other descriptive results were reported.

Adult↗