Search PubMed⌕ Search

Biomedical subjects

W F Jarrett

Publications and source records attributed to W F Jarrett.

At least 55 records · Page 3Linked to original sources
PubMed1978

High incidence area of cattle cancer with a possible interaction between an environmental carcinogen and a papilloma virus.

Cattle in upland areas of Scotland and northern England are substantially more prone to alimentary cancer than those of the immediately neighbouring lowlands, and epidemiological evidence implicates a combination of papilloma virus and bracken in the aetiology of the disease. Here Professor Jarrett outlines the circumstantial case against these agents and discusses its implications.

Animals↗
PubMed1978

Transformation of warts to malignancy in alimentary carcinoma in cattle.

There is a high incidence of alimentary carcinoma in beef cattle in the highland areas of Britain. Evidence is presented to shown that this is associated with the presence of bracken fern on high incidence farms and that many of the carcinomas arise in pre-existing virus-induced papillomas. Papillomas are much commoner and occur in greater numbers in animals of all ages on the cancer farms as compared to lowland cattle. Papillomas are found in all ages of cattle; carcinomas have only been seen in cows over 6 years of age. The virus has been isolated, visualized and purified; it produces papillomas when inoculated into the alimentary tract and skin.

Animals↗
PubMed1975

The relation of immune response to pathogenesis, vaccination and epidemiology in virus induced leukaemia.

The antigenic systems of oncornaviruses and particularly feline leukaemia virus (FeLV) are reviewed briefly. The use of immunological methods in studying the epidemiology of the disease is described. The incidence of FeLV infection as judged by a serological survey is at least 100 times greater than that of leukaemia in the cat population. Horizontal transmission, due to virus replication in respiratory and alimentary epithelial cells, is common. A method of producing high titres of antibody against membrane antigens of virus infected cells is described; the use of such vaccination is discussed in relation to several epidemiological facets of feline leukaemia virus infection. Leukaemia viruses are well known to cause immunodepression to heterologous antigens. The hypothesis is advanced that depression of the humoral antibody response to leukaemia virus antigens and cell membrane antigens may be an early event allowing establishment and replication of virus in haemic and the lymphatic tissues. Subsequent depression of cell mediated immunity through direct action of thymic cells is known to take place in the cat system. This may allow further spread of the virus with replication in epithelial cells which are not susceptible to cytotoxic action. Thus the primary events leading to leukaemogenesis may be an interplay between immunostimulation and immunodepression.

Animals↗
PubMed1974

Neoplastic diseases of the haematopoietic and lymphoid tissues.

Systemic lymphosarcomas are common in all species of domestic mammal. A binomial classification of these tumours, based on both the anatomical form (i.e., distribution of lesions) and the type of cytology, is proposed. Mast cell tumours also are common, especially in the dog. The categories of lymphoid neoplasms described are: lymphosarcoma, lymphoid leukaemia, nodular lymphoid hyperplasia, tumours of the immunoglobulin-forming cells, and thymoma. The myeloid neoplasms described are: myeloid leukaemia, erythroleukaemia, acute erythraemia, polycythaemia vera, megakaryocytoid leukaemia, panmyelosis, myelosclerosis, and monocytoid leukaemia. Mast cell tumours are divided into mastocytoma and malignant mastocytosis.

Animals↗
PubMed1971

Feline leukemia.

Explore the source record for details and available documents.

Animals↗